Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants (LiveForLife2)

Inclusion Criteria:

• Duke employees who are enrolled in a Duke Health Plan and intend to remain employed at Duke for the next six months;
• Dependents of Duke employees who meet the above criteria;
• 18-65 years old;
• Currently smoke an average of at least 10 cigarettes per day;
• Willing to take Chantix or Zyban;
• Express a desire to quit smoking within the next 30 days.

Exclusion Criteria:

• Hypertension;
• Hypotension with symptoms (systolic <90 mm Hg, diastolic <60 mm Hg);
• Coronary heart disease;
• Lifetime history of heart attack;
• Cardiac rhythm disorder (irregular heart rhythm);
• Chest pains (unless history, exam, and ECG clearly indicate a non-cardiac source);
• Cardiac (heart) disorder (including but not limited to valvular heart disease, heart murmur, heart failure);
• Extensive active skin disorder;
• Liver or kidney disorder (except kidney stones, gallstones);
• Gastrointestinal disease other than gastroesophageal reflux or heartburn;
• Active ulcers in the past 30 days;
• Currently symptomatic lung disorder/disease (including but not limited to COPD, emphysema, and asthma);
• Brain abnormality (including but not limited to stroke, brain tumor, and seizure disorder);
• Migraine headaches that occur more frequently than once per week;
• Recent, unexplained fainting spells;
• Diabetes treated with insulin; non-insulin treated diabetes (unless glucose is less than 180mg/dcl and HbA1c is less than 7%);
• Current cancer or treatment for cancer in the past six months (except basal or squamous cell skin cancer);
• Other major medical condition;
• Suicidal ideation (within the past 10 years) or lifetime occurrence of attempted suicide;
• Pregnant or nursing mothers;
• Current psychiatric disease (with the exception of anxiety disorders, OCD and ADHD);
• Current depression;
• Bulimia or anorexia;
• Alcohol abuse;
• Significant adverse reaction to bupropion/Wellbutrin/Zyban, Chantix/Varenicline or nicotine patches in the past.

• Use (within the past 30 days) of:

  • Wellbutrin, bupropion, Zyban, Chantix, nicotine replacement therapy or any other smoking cessation aid.
  • Medications that are known to affect smoking cessation.