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Safety and Efficacy Study Using ABT-335 (Investigational Drug) in Combination With Atorvastatin, to Study the Effects on Thickening of the Blood Vessel Wall in Patients With Abnormal Lipid (Fat) Levels in the Blood (FIRST)

1. juni 2018 opdateret af: AbbVie (prior sponsor, Abbott)

Evaluation of Choline Fenofibrate (ABT-335) on Carotid Intima-Media Thickness (cIMT) in Subjects With Type IIb Dyslipidemia With Residual Risk in Addition to Atorvastatin Therapy (FIRST) Trial

The primary purpose of this study is to test the effect and safety of once daily ABT-335 on the thickness of the lining of the carotid artery (a blood vessel to the brain) in patients with abnormal blood lipids who have optimal levels of low density lipoprotein cholesterol ("bad cholesterol") after taking atorvastatin.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

682

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Arizona
  - Chandler, Arizona, Forenede Stater, 85225
    - Site Reference ID/Investigator# 6747
  - Gilbert, Arizona, Forenede Stater, 85295
    - Site Reference ID/Investigator# 7089
  - Mesa, Arizona, Forenede Stater, 85206
    - Site Reference ID/Investigator# 7097
  - Phoenix, Arizona, Forenede Stater, 85032
    - Site Reference ID/Investigator# 26394
  - Scottsdale, Arizona, Forenede Stater, 85251
    - Site Reference ID/Investigator# 6848
  - Tempe, Arizona, Forenede Stater, 85282
    - Site Reference ID/Investigator# 7059
  - Tempe, Arizona, Forenede Stater, 85282
    - Site Reference ID/Investigator# 7094
  - Tempe, Arizona, Forenede Stater, 85282
    - Site Reference ID/Investigator# 7098
- California
  - Anaheim, California, Forenede Stater, 92804
    - Site Reference ID/Investigator# 25082
  - Corona, California, Forenede Stater, 92879-3109
    - Site Reference ID/Investigator# 21347
  - Garden Grove, California, Forenede Stater, 92843
    - Site Reference ID/Investigator# 21483
  - Huntington Beach, California, Forenede Stater, 92648
    - Site Reference ID/Investigator# 21351
  - Laguna Hills, California, Forenede Stater, 92653
    - Site Reference ID/Investigator# 21346
  - Long Beach, California, Forenede Stater, 90806
    - Site Reference ID/Investigator# 21341
  - Norwalk, California, Forenede Stater, 90650
    - Site Reference ID/Investigator# 21342
  - Santa Ana, California, Forenede Stater, 92705
    - Site Reference ID/Investigator# 21321
  - Tustin, California, Forenede Stater, 92780
    - Site Reference ID/Investigator# 26242
- Colorado
  - Arvada, Colorado, Forenede Stater, 80005-3927
    - Site Reference ID/Investigator# 15283
  - Aurora, Colorado, Forenede Stater, 80012
    - Site Reference ID/Investigator# 7085
  - Denver, Colorado, Forenede Stater, 80239
    - Site Reference ID/Investigator# 6749
  - Denver, Colorado, Forenede Stater, 80246
    - Site Reference ID/Investigator# 7077
  - Golden, Colorado, Forenede Stater, 80401
    - Site Reference ID/Investigator# 7092
  - Littleton, Colorado, Forenede Stater, 80122
    - Site Reference ID/Investigator# 7722
  - Littleton, Colorado, Forenede Stater, 80127
    - Site Reference ID/Investigator# 7721
- Florida
  - Aventura, Florida, Forenede Stater, 33180
    - Site Reference ID/Investigator# 11925
  - Boynton Beach, Florida, Forenede Stater, 33472
    - Site Reference ID/Investigator# 15861
  - Deerfield Beach, Florida, Forenede Stater, 33442
    - Site Reference ID/Investigator# 14422
  - Delray Beach, Florida, Forenede Stater, 33445
    - Site Reference ID/Investigator# 19281
  - Hollywood, Florida, Forenede Stater, 33021
    - Site Reference ID/Investigator# 20881
  - Kissimmee, Florida, Forenede Stater, 34741
    - Site Reference ID/Investigator# 20882
  - Melbourne, Florida, Forenede Stater, 32901
    - Site Reference ID/Investigator# 19321
  - Melbourne, Florida, Forenede Stater, 32901
    - Site Reference ID/Investigator# 21353
  - Melbourne, Florida, Forenede Stater, 32935
    - Site Reference ID/Investigator# 18503
  - Vero Beach, Florida, Forenede Stater, 32960
    - Site Reference ID/Investigator# 18841
  - Vero Beach, Florida, Forenede Stater, 32960
    - Site Reference ID/Investigator# 19961
  - West Palm Beach, Florida, Forenede Stater, 33401
    - Site Reference ID/Investigator# 7166
  - West Palm Beach, Florida, Forenede Stater, 33407
    - Site Reference ID/Investigator# 6744
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30308
    - Site Reference ID/Investigator# 19301
  - Atlanta, Georgia, Forenede Stater, 30342-1524
    - Site Reference ID/Investigator# 7051
  - Atlanta, Georgia, Forenede Stater, 30342
    - Site Reference ID/Investigator# 7109
  - Dawsonville, Georgia, Forenede Stater, 30534
    - Site Reference ID/Investigator# 7326
  - Decatur, Georgia, Forenede Stater, 30033
    - Site Reference ID/Investigator# 7325
  - Dunwoody, Georgia, Forenede Stater, 30338
    - Site Reference ID/Investigator# 7057
  - Dunwoody, Georgia, Forenede Stater, 30338
    - Site Reference ID/Investigator# 7101
  - Roswell, Georgia, Forenede Stater, 30076
    - Site Reference ID/Investigator# 11324
  - Roswell, Georgia, Forenede Stater, 30076
    - Site Reference ID/Investigator# 6741
  - Suwanee, Georgia, Forenede Stater, 30024
    - Site Reference ID/Investigator# 7103
- Illinois
  - Addison, Illinois, Forenede Stater, 60101
    - Site Reference ID/Investigator# 10761
  - Aurora, Illinois, Forenede Stater, 60504
    - Site Reference ID/Investigator# 6748
  - Aurora, Illinois, Forenede Stater, 60506
    - Site Reference ID/Investigator# 6742
  - Belleville, Illinois, Forenede Stater, 62220-1986
    - Site Reference ID/Investigator# 7128
  - Chicago, Illinois, Forenede Stater, 60607
    - Site Reference ID/Investigator# 7069
  - Chicago, Illinois, Forenede Stater, 60612-9985
    - Site Reference ID/Investigator# 6849
  - Chicago, Illinois, Forenede Stater, 60612
    - Site Reference ID/Investigator# 6867
  - Chicago, Illinois, Forenede Stater, 60616
    - Site Reference ID/Investigator# 6751
  - Chicago, Illinois, Forenede Stater, 60631
    - Site Reference ID/Investigator# 6847
  - Chicago, Illinois, Forenede Stater, 60654
    - Site Reference ID/Investigator# 7049
  - Gurnee, Illinois, Forenede Stater, 60031
    - Site Reference ID/Investigator# 7093
  - Hazel Crest, Illinois, Forenede Stater, 60429
    - Site Reference ID/Investigator# 6746
  - Melrose Park, Illinois, Forenede Stater, 60160
    - Site Reference ID/Investigator# 6743
  - Naperville, Illinois, Forenede Stater, 60564
    - Site Reference ID/Investigator# 7090
  - Oak Brook, Illinois, Forenede Stater, 60523
    - Site Reference ID/Investigator# 6750
  - Oak Park, Illinois, Forenede Stater, 60304
    - Site Reference ID/Investigator# 6788
  - Vernon Hills, Illinois, Forenede Stater, 60061
    - Site Reference ID/Investigator# 6927
- Kentucky
  - Erlanger, Kentucky, Forenede Stater, 41018
    - Site Reference ID/Investigator# 7076
- Minnesota
  - Bloomington, Minnesota, Forenede Stater, 55420
    - Site Reference ID/Investigator# 8103
  - Brooklyn Center, Minnesota, Forenede Stater, 55430
    - Site Reference ID/Investigator# 15121
  - Edina, Minnesota, Forenede Stater, 55435
    - Site Reference ID/Investigator# 7050
  - Edina, Minnesota, Forenede Stater, 55435
    - Site Reference ID/Investigator# 7084
- Missouri
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Site Reference ID/Investigator# 6860
  - Saint Louis, Missouri, Forenede Stater, 63117
    - Site Reference ID/Investigator# 13182
  - Saint Louis, Missouri, Forenede Stater, 63128
    - Site Reference ID/Investigator# 14423
  - Saint Louis, Missouri, Forenede Stater, 63141-6399
    - Site Reference ID/Investigator# 14541
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Site Reference ID/Investigator# 6740
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Site Reference ID/Investigator# 7053
  - Saint Peters, Missouri, Forenede Stater, 63376
    - Site Reference ID/Investigator# 6784
- Nevada
  - Henderson, Nevada, Forenede Stater, 89014
    - Site Reference ID/Investigator# 7063
  - Henderson, Nevada, Forenede Stater, 89052
    - Site Reference ID/Investigator# 7070
  - Las Vegas, Nevada, Forenede Stater, 89104
    - Site Reference ID/Investigator# 7106
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Site Reference ID/Investigator# 7518
  - Las Vegas, Nevada, Forenede Stater, 89146
    - Site Reference ID/Investigator# 7119
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Site Reference ID/Investigator# 7129
- Ohio
  - Cincinnati, Ohio, Forenede Stater, 45212
    - Site Reference ID/Investigator# 7071
  - Cincinnati, Ohio, Forenede Stater, 45219
    - Site Reference ID/Investigator# 7100
  - Cincinnati, Ohio, Forenede Stater, 45224
    - Site Reference ID/Investigator# 14321
  - Cincinnati, Ohio, Forenede Stater, 45245
    - Site Reference ID/Investigator# 21355
  - Cincinnati, Ohio, Forenede Stater, 45246
    - Site Reference ID/Investigator# 7074
  - Cincinnati, Ohio, Forenede Stater, 45249
    - Site Reference ID/Investigator# 7065
  - Dayton, Ohio, Forenede Stater, 45439
    - Site Reference ID/Investigator# 7075
  - Kettering, Ohio, Forenede Stater, 45429
    - Site Reference ID/Investigator# 24802
  - Mason, Ohio, Forenede Stater, 45040
    - Site Reference ID/Investigator# 7068
- Texas
  - Bellaire, Texas, Forenede Stater, 77401
    - Site Reference ID/Investigator# 7104
  - Carrollton, Texas, Forenede Stater, 75006-5810
    - Site Reference ID/Investigator# 7060
  - Dallas, Texas, Forenede Stater, 75230
    - Site Reference ID/Investigator# 15282
  - Dallas, Texas, Forenede Stater, 75231
    - Site Reference ID/Investigator# 6745
  - Dallas, Texas, Forenede Stater, 75231
    - Site Reference ID/Investigator# 7083
  - Dallas, Texas, Forenede Stater, 75231
    - Site Reference ID/Investigator# 7127
  - Dallas, Texas, Forenede Stater, 75251
    - Site Reference ID/Investigator# 7110
  - Deer Park, Texas, Forenede Stater, 77536
    - Site Reference ID/Investigator# 21356
  - Fort Worth, Texas, Forenede Stater, 76116
    - Site Reference ID/Investigator# 11923
  - Houston, Texas, Forenede Stater, 77002
    - Site Reference ID/Investigator# 7321
  - Houston, Texas, Forenede Stater, 77024
    - Site Reference ID/Investigator# 21354
  - Houston, Texas, Forenede Stater, 77030
    - Site Reference ID/Investigator# 21358
  - Houston, Texas, Forenede Stater, 77030
    - Site Reference ID/Investigator# 26482
  - Houston, Texas, Forenede Stater, 77030
    - Site Reference ID/Investigator# 7079
  - Houston, Texas, Forenede Stater, 77030
    - Site Reference ID/Investigator# 7096
  - Houston, Texas, Forenede Stater, 77036
    - Site Reference ID/Investigator# 7126
  - Houston, Texas, Forenede Stater, 77036
    - Site Reference ID/Investigator# 8186
  - Houston, Texas, Forenede Stater, 77074
    - Site Reference ID/Investigator# 11323
  - Houston, Texas, Forenede Stater, 77081
    - Site Reference ID/Investigator# 7130
  - Irving, Texas, Forenede Stater, 75039
    - Site Reference ID/Investigator# 11924
  - Irving, Texas, Forenede Stater, 75061
    - Site Reference ID/Investigator# 13863
  - McKinney, Texas, Forenede Stater, 75069
    - Site Reference ID/Investigator# 7099
  - New Braunfels, Texas, Forenede Stater, 78130
    - Site Reference ID/Investigator# 19121
  - Pearland, Texas, Forenede Stater, 77584
    - Site Reference ID/Investigator# 26244
  - Plano, Texas, Forenede Stater, 75024
    - Site Reference ID/Investigator# 7105
  - San Antonio, Texas, Forenede Stater, 78205
    - Site Reference ID/Investigator# 7061
  - San Antonio, Texas, Forenede Stater, 78215
    - Site Reference ID/Investigator# 7320
  - San Antonio, Texas, Forenede Stater, 78218
    - Site Reference ID/Investigator# 7914
  - San Antonio, Texas, Forenede Stater, 78229-4801
    - Site Reference ID/Investigator# 7058
  - San Antonio, Texas, Forenede Stater, 78229
    - Site Reference ID/Investigator# 18402
  - San Antonio, Texas, Forenede Stater, 78229
    - Site Reference ID/Investigator# 7052
  - San Antonio, Texas, Forenede Stater, 78229
    - Site Reference ID/Investigator# 7062
  - San Antonio, Texas, Forenede Stater, 78238-1434
    - Site Reference ID/Investigator# 22947

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

45 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

Patients with mixed dyslipidemia
Qualifying cIMT thickness

Exclusion Criteria:

Patients with certain chronic or unstable medical conditions.
Patients with unstable dose of medications or receiving coumadin, cyclosporine, or certain other medications
Pregnant or lactating women or women intending to become pregnant
Patients with diabetes mellitus that is poorly controlled

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Firedobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: ABT-335 + Atorvastatin ABT-335 (135 mg) and atorvastatin (up to 40 mg) once daily for 2 years.	Medicin: ABT-335 Capsule Andre navne: Fenofibrinsyre Choline fenofibrate Andet: Atorvastatin Capsule
Placebo komparator: Placebo + Atorvastatin Placebo and atorvastatin (up to 40 mg) once daily for 2 years.	Medicin: Placebo Kapsel Andet: Atorvastatin Capsule

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Rate of Change in Mean Posterior-wall Carotid Intima-media Thickness (cIMT) Tidsramme: Baseline, 6 months, 12 months, 18 months, and 24 months	Rate of change (mm/year) from baseline in mean of posterior-wall carotid intima-media thickness (cIMT) of the left and right common carotid artery. The statistical model used change from baseline as the dependent variable, with time of cIMT assessment (in years) as one of the factors in the model. The between-group difference in the rate of change was based on the parameter coefficient for the time-by-treatment interaction. The within-group rate of change was obtained from estimate statements within the repeated measures analysis. cIMT was measured using non-invasive ultrasound.	Baseline, 6 months, 12 months, 18 months, and 24 months

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Rate of Change in Mean of Maximal Posterior-wall Carotid Intima-media Thickness (cIMT) Tidsramme: Baseline, 6 months, 12 months, 18 months, and 24 months	Rate of change (mm/year) from baseline in mean of maximal posterior-wall carotid intima-media thickness (cIMT) of the left and right common carotid artery. The statistical model used change from baseline as the dependent variable, with time of cIMT assessment (in years) as one of the factors in the model. The between-group difference in the rate of change was based on the parameter coefficient for the time-by-treatment interaction. The within-group rate of change was obtained from estimate statements within the repeated measures analysis. cIMT was measured using non-invasive ultrasound.	Baseline, 6 months, 12 months, 18 months, and 24 months
Rate of Change in Composite of Mean of the Mean Posterior-wall Intima-media Thickness (IMT) Tidsramme: Baseline, 6 months, 12 months, 18 months, and 24 months	Rate of change (mm/year) from baseline in composite of mean of the mean posterior-wall intima-media thickness (IMT) of the left and right common carotid artery, internal carotid artery, and carotid bifurcation. The statistical model used change from baseline as the dependent variable, with time of IMT assessment (in years) as one of the factors in the model. The between-group difference in the rate of change was based on the parameter coefficient for the time-by-treatment interaction. The within-group rate of change was obtained from estimate statements within the repeated measures analysis. IMT was measured using non-invasive ultrasound.	Baseline, 6 months, 12 months, 18 months, and 24 months
Rate of Change in Composite of Mean of Maximal Posterior-wall Intima-media Thickness (IMT) Tidsramme: Baseline, 6 months, 12 months, 18 months, and 24 months	Rate of change (mm/year) from baseline in composite of mean of maximal posterior-wall intima-media thickness (IMT) of the left and right common carotid artery, internal carotid artery, and carotid bifurcation. The statistical model used change from baseline as the dependent variable, with time of IMT assessment (in years) as one of the factors in the model. The between-group difference in the rate of change was based on the parameter coefficient for the time-by-treatment interaction. The within-group rate of change was obtained from estimate statements within the repeated measures analysis. IMT was measured using non-invasive ultrasound.	Baseline, 6 months, 12 months, 18 months, and 24 months
Rate of Change in Composite of Mean of Maximal Posterior-wall and Anterior-wall Intima-media Thickness (IMT) Tidsramme: Baseline, 6 months, 12 months, 18 months, and 24 months	Rate of change (mm/year) from baseline in composite of mean of maximal posterior-wall and anterior-wall intima-media thickness (IMT) of the left and right common carotid artery, internal carotid artery, and carotid bifurcation. The statistical model used change from baseline as the dependent variable, with time of IMT assessment (in years) as one of the factors in the model. The between-group difference in the rate of change was based on the parameter coefficient for the time-by-treatment interaction. The within-group rate of change was obtained from estimate statements within the repeated measures analysis. IMT was measured using non-invasive ultrasound.	Baseline, 6 months, 12 months, 18 months, and 24 months

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

AbbVie (prior sponsor, Abbott)

Efterforskere

Studieleder: Maureen Kelly, MD, AbbVie

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Davidson M, Rosenson RS, Maki KC, Nicholls SJ, Ballantyne CM, Setze C, Carlson DM, Stolzenbach J. Study design, rationale, and baseline characteristics: evaluation of fenofibric acid on carotid intima-media thickness in patients with type IIb dyslipidemia with residual risk in addition to atorvastatin therapy (FIRST) trial. Cardiovasc Drugs Ther. 2012 Aug;26(4):349-58. doi: 10.1007/s10557-012-6395-z.

Hjælpsomme links

Related Info

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. februar 2008

Primær færdiggørelse (Faktiske)

1. september 2012

Studieafslutning (Faktiske)

1. september 2012

Datoer for studieregistrering

Først indsendt

5. februar 2008

Først indsendt, der opfyldte QC-kriterier

14. februar 2008

Først opslået (Skøn)

15. februar 2008

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

2. juli 2018

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

1. juni 2018

Sidst verificeret

1. december 2013

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

M10-158

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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Hypoplastisk venstre hjerte syndrom

Forenede Stater

Safety and Efficacy Study Using ABT-335 (Investigational Drug) in Combination With Atorvastatin, to Study the Effects on Thickening of the Blood Vessel Wall in Patients With Abnormal Lipid (Fat) Levels in the Blood (FIRST)

Evaluation of Choline Fenofibrate (ABT-335) on Carotid Intima-Media Thickness (cIMT) in Subjects With Type IIb Dyslipidemia With Residual Risk in Addition to Atorvastatin Therapy (FIRST) Trial

Studieoversigt

Status

Betingelser

Intervention / Behandling

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Studer store datoer

Studiestart

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Koronararteriesygdom

Kliniske forsøg med Placebo

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Papua New Guinea

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer