- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT02145377
PXVX0200 (CVD103-HgR) vs Shanchol in Mali
A Phase 2 Randomized, Double-Blinded Study to Compare in Malian Adults the Immunogenicity, Clinical Acceptability and Excretion Pattern Following the Ingestion of a Single Dose of PXVX0200 (CVD 103-HgR) Live Oral Cholera Vaccine Containing Either 108 Colony Forming Units [Cfu] or 109 Cfu Using Shanchol™ Killed Whole Cell Oral Cholera Vaccine as an Immunological Comparator
To compare the ability of a single dose of PXVX0200 at two different dose levels, to placebo to elicit a significant antibody response 14 days after vaccination, compared to baseline.
To compare the ability of a single dose of PXVX0200 to a comparator vaccine Shanchol, a two dose administration, to elicit antibody response by 14 days after vaccination.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Currently there are two licensed inactivated vibrio oral vaccines (Dukoral® [Crucell; Leiden, The Netherlands] and Shanchol™ [Shantha Biotechnics; Hyderabad, India]) that are pre-qualified by the World Health Organization (WHO) for procurement by United Nations (UN) agencies. Each of these vaccines requires a two-dose regimen which is difficult to implement in the face of explosive outbreaks of cholera in unsettled situations in developing countries. For this reason there is great interest in identifying a cholera vaccine that can provide rapid onset of protection following the ingestion of just a single oral dose.
This Phase 2 randomized, observer-blinded and subject-blinded clinical trial to be conducted in Bamako, Mali will assess the immunogenicity of the 10^8 cfu versus the 10^9 cfu formulation of PaxVax-manufactured CVD 103-HgR.
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Fase 2
Kontakter og lokationer
Studiesteder
-
-
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Bamako, Mali
- Centre pour le Développement des Vaccins, Mali (CVD-Mali)
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Able to understand the study and give consent (either written or through a process that involves audio tapes explaining all aspects of the study and the consent form in local languages [Bambara and French] followed by making a mark and signature by a literate witness)
- Healthy men or women, age 18 to 45 years (inclusive) without significant medical history
- Women of child-bearing potential must have negative urine pregnancy test at baseline, prior to vaccination. They must also be willing to use adequate birth control for the duration of the 28-day study and have additional pregnancy tests if indicated. Effective methods of birth control for this study include abstinence, intrauterine device (IUD), oral or depot contraceptive, or barrier plus spermicide
- Willingness to remain in the study area until at least 42 days after receipt of the first vaccine dose
Exclusion Criteria:
- Health care workers who have direct contact with patients who are immune deficient, HIV-positive, or have an unstable medical condition
- Clinically significant history of immunodeficiency, cardiovascular disease, respiratory disease, endocrine disorder, liver disease, renal disease, gastrointestinal disease, neurologic illness, psychiatric disorder requiring hospitalization, current drug or alcohol abuse
- History of an abnormal stool pattern or regular use of laxatives
- Previously received a licensed or investigational cholera vaccine
- History of cholera illness
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Forebyggelse
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Tredobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: PXVX0200 10E8 then placebo
PXVX0200 10E8 on day 0; Placebo on day 14
|
Oral dose of PXVX0200 10E8
Oral dose of sodium bicarbonate buffer
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Eksperimentel: Placebo, then PXVX0200 10E8
Placebo on day 0; PXVX0200 10E8 on day 14
|
Oral dose of PXVX0200 10E8
Oral dose of sodium bicarbonate buffer
|
Eksperimentel: PXVX0200 10E9 then Placebo
PXVX0200 10E9 on day 0; Placebo on day 14
|
Oral dose of sodium bicarbonate buffer
Oral dose of PXVX0200 10E9
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Eksperimentel: Placebo then PXVX0200 10E9
Placebo on day 0; PXVX0200 10E9 on day 14
|
Oral dose of sodium bicarbonate buffer
Oral dose of PXVX0200 10E9
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Aktiv komparator: Shanchol
Two doses of Shanchol, on day 0 and day 14
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Licensed comparator
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
To elicit a significant rise in serum Inaba vibriocidal antibody after a single vaccination
Tidsramme: 14 days
|
A comparison of the ability of a single ≥2 x10E9 cfu oral dose versus a single ≥2 x10E8 cfu oral dose of PXVX0200 (CVD 103-HgR) versus placebo to elicit a significant (> 4-fold) rise in serum Inaba vibriocidal antibody 14 days after vaccination, compared to baseline
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14 days
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
To measure antibody response for a 10E8 dose and 10E9 dose of PXVX0200 oral vaccine
Tidsramme: 14 days
|
To compare the ability of a single ≥2 x108 cfu dose of PXVX0200 (CVD 103-HgR) or ≥2 x109 oral dose of PXVX0200 (CVD 103-HgR) versus Shanchol™ to elicit serum Inaba vibriocidal antibody mean fold rise (compared to baseline titer) and GMT
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14 days
|
To plot the kinetics of the serum Inaba Vibriocidal antibody response
Tidsramme: Baseline and post-vaccination time point.
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To plot the kinetics of the serum Inaba vibriocidal antibody response after ingestion of a single oral dose of PXVX0200 (CVD 103-HgR) containing ≥2 x10E8 cfu or ≥2 x10E9 cfu versus Shanchol™.
(With GMT on the Y axis and time points on the X axis, the GMTs at baseline and at each post-vaccination time point will be connected as a line graph).
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Baseline and post-vaccination time point.
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Assess fecal shedding of PXVX0200
Tidsramme: Day 1-3, day 7 and day 14
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Shedding of CVD 103-HgR in stool as determined by stool culture (whole specimen or rectal swab)
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Day 1-3, day 7 and day 14
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Compare rate of diarrhea
Tidsramme: 7 days
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To compare the rate of diarrhea (≥ 4 loose stools within 24 hours) following administration of each vaccine regimen versus placebo over 7 days of follow-up
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7 days
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Andre resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Plot seroconversion
Tidsramme: Day 7, 14, 21, 28, 35 and 42
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To plot the seroconversion (≥ 4-fold increase over baseline), mean fold rise (comparing baseline titer with post-vaccination titer), and kinetics of serum IgG cholera antitoxin antibody following the ingestion of a single oral dose of PXVX0200 (CVD 103-HgR) containing ≥2 x10E8 cfu or ≥2 x10E9 cfu versus Shanchol™.
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Day 7, 14, 21, 28, 35 and 42
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Assess reactogenicity
Tidsramme: For seven days after each dose of PXVX0200
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Assess tiredness, vomiting, loss of appetite, abdominal pain and headache
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For seven days after each dose of PXVX0200
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Samarbejdspartnere og efterforskere
Efterforskere
- Ledende efterforsker: Samba O Sow, MD, MS, Centre pour le Developpement des Vaccins - Mali
Publikationer og nyttige links
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- HP-00059690
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