- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT02441335
CellulaR Injury and Preterm Birth (CRIB)
2. oktober 2019 opdateret af: University of Pennsylvania
The goal of this study is to examine how cellular dysfunction can lead to preterm birth.
Women with singleton pregnancies with spontaneous preterm labor, preterm premature rupture of membranes, and cervical insufficiency (20 to 36-6/7 weeks gestation), and term deliveries (greater than 38 weeks) will be enrolled.
Medical/obstetric history and pregnancy outcomes will be recorded.
Maternal blood, urine and cervical cells (enrollment); cord blood and placental biopsy (delivery) will be collected.
Studieoversigt
Status
Afsluttet
Betingelser
Detaljeret beskrivelse
Despite improvements in prenatal care, preterm birth (PTB) remains a leading contributor to perinatal morbidity and mortality.
Several genetic and environmental factors have been associated with spontaneous preterm birth, but the pathways by which these factors induce preterm delivery have not been defined.
The March of Dimes CPR at the University of Pennsylvania was created to help elucidate the pathogenesis of preterm birth by bringing together a diverse team of investigators with expertise in preterm birth, cellular metabolism, genetics, mitochondrial functional analyses, genome, epigenome, and transcriptome profiling, integrated bioinformatics analyses, and microbiome research.
The center will focus on addressing the interactions between bioenergetics, genetics, microbiome, abnormal cervical remodeling and placental dysfunction.
Each one of these factors will be studied independently and in relation to the other factors.
In order to study metabolic processes in relation to spontaneous PTB, a prospective case-control study will be performed.
This study will involve women with singleton pregnancies with spontaneous preterm labor (PTL), preterm premature rupture of membranes (PPROM), and cervical insufficiency, between 20-0/7 and 36-6/7 weeks gestational age (cases), and women with term deliveries (38 to 41 weeks gestation, controls).
The investigators will obtain information regarding the patients' pertinent past medical and obstetric histories, and the following specimens will be collected: maternal blood, maternal urine, and cervical epithelial cells at enrollment; and umbilical cord blood and placental biopsies at delivery.
We will follow and record each of these patients' pregnancy outcomes.
Undersøgelsestype
Observationel
Tilmelding (Faktiske)
705
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Pennsylvania
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Philadelphia, Pennsylvania, Forenede Stater, 19104
- Hospital of the University of Pennsylvania
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 45 år (Voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Kvinde
Prøveudtagningsmetode
Ikke-sandsynlighedsprøve
Studiebefolkning
At HUP, there are approximately 4,200 deliveries a year, of which approximately 10 percent (420) deliver preterm.
Among these preterm births, two-thirds (280) are spontaneous, which is the focus of our research.
Many women who ultimately have a preterm birth, first present with preterm labor.
Women who have advanced dilatation, preterm rupture of membranes, etc are at high risk for having a preterm birth.
The investigators anticipate, based on the number of spontaneous preterm births at HUP per year, enrolling about 40-50% of those eligible and understanding that about 40% of those enrolled will have a preterm birth, we should be able to enroll about 112 women per year over 5 years.
The coordinators will enroll cases who are admitted to the hospital with PTL, PPROM, or cervical insufficiency at 20-0/7 to 36-6/7 weeks.
Beskrivelse
Cases:
Inclusion Criteria:
- 18-45 years of age
- Singleton pregnancy between 20 0/7 and 36 6/7 weeks gestational age who is admitted with preterm labor or cervical insufficiency (greater than 2 cm dilation) or Preterm Premature Rupture of Membranes
Exclusion Criteria:
- Multiple gestation
- Fetal chromosomal abnormality
- Major fetal anomaly
- Intra-uterine fetal demise
- Gestational hypertension/preeclampsia
Controls:
Inclusion Criteria:
- 18-45 years of age
- Singleton pregnancy that delivers at term (38 to 41 weeks gestational age)
- Admitted to the hospital with spontaneous labor (regular contractions, cervical dilation) or spontaneous rupture of membranes
Exclusion Criteria:
- Multiple gestation
- Fetal chromosomal abnormality
- Major fetal anomaly
- Intra-uterine fetal demise
- Intra-uterine growth restriction
- Gestational hypertension/preeclampsia
- Clinical chorioaminionitis
- Induction of labor
- Elective c-section
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
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Group 1 (Preterm labor, PPROM, cervical insufficiency)
Singleton pregnancy between 20 0/7 36 6/7 weeks gestational age who is admitted with PTL or cervical insufficiency (Equal or greater than 2 cm dilated) or PPROM
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Group 2 (Term labor)
Admitted to the hospital with spontaneous labor (regular contractions, cervical dilation) or spontaneous rupture of membranes
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Group 3 (PTB-medically indicated)
Singleton pregnancy between 20 0/7 34 5/6 weeks gestational age who is admitted with a medically indicated preterm birth (IOL for abruption, non reassuring fetal heart tones, intrauterine growth restriction, preeclampsia, trauma, etc.)
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Biogenetics
Tidsramme: 5 years
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The role of biogenetics in pregnancy and what are the perturbations in cell metabolism that lead to spontaneous preterm birth.
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5 years
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Microbiome
Tidsramme: 5 years
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The interactions between the microbiome (oral, gut, cervicovaginal, and placental) and host metabolic function in pregnancy.
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5 years
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Cervical remodeling
Tidsramme: 5 years
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How the interactions between cell metabolism and the microbiome influence cervical remodeling and placental function leading to spontaneous preterm delivery.
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5 years
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Genetics and Environmental factors
Tidsramme: 5 years
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How genetic and environmental factors influence the metabolic function of reproductive tissues leading to spontaneous preterm delivery.
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5 years
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Michal Elovitz, MD, University of Pennsylvania
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. januar 2015
Primær færdiggørelse (Faktiske)
1. august 2019
Studieafslutning (Faktiske)
1. august 2019
Datoer for studieregistrering
Først indsendt
6. april 2015
Først indsendt, der opfyldte QC-kriterier
7. maj 2015
Først opslået (Skøn)
12. maj 2015
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
7. oktober 2019
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
2. oktober 2019
Sidst verificeret
1. oktober 2019
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 821376
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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