Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Clinical and Morphological Characteristics of Chronic Inflammation in the Myocardium in Patients With Decompensated HF With Ischemic Systolic Dysfunction (FHID)

5. januar 2016 opdateret af: Vyacheslav Ryabov, Russian Academy of Medical Sciences

Clinical and Morphological Characteristics of Chronic Inflammation in the Myocardium in Patients With Decompensated Heart Failure With Ischemic Systolic Dysfunction

The purpose of the study is to investigate the clinical and morphological characteristics of chronic subclinical inflammation in the myocardium in patients with decompensated heart failure with ischemic systolic dysfunction.

Studieoversigt

Status

Ukendt

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Important reason for the development of chronic heart failure is a viral disease of the heart, the three phenotypes associated with: the presence of inflammation without viral agent, implying an autoimmune disease; presence of inflammation and persistent viruses; and the presence of persistent virus without signs of inflammation.

There is a group of patients with coronary heart disease, which on the background of optimal treatment is observed progression of clinical symptoms of coronary heart disease with the subsequent development of heart failure, leading to ischemic cardiomyopathy. Perhaps the reason for this is the combination of inflammatory and ischemic cardiomyopathies.

Inflammatory cardiomyopathy, involved in the pathogenesis of DCM, includes idiopathic, autoimmune and infectious subtypes. Inflammatory disease of the myocardium diagnosed by established histological, immunological and immunohistochemical criteria.

This study will include 60 patients with decompensated heart failure with ischemic left ventricular systolic dysfunction (LVEF <40%) were hospitalized not earlier than 6 months after myocardial revascularization. This group of patients will receive standard treatment, according to national guidelines RSC and ESC, to stabilize heart failure. All patients will be held PCI to exclude ischemic heart failure decompensation. Also, all patients will be performed endomyocardial biopsy as a result of immunohistochemical studies will be made on the separation of the virus and the virus-negative-positive group. After that, the group will be divided into subgroups: virus - and inflammation in the myocardium inflammation without viral antigen, viral inflammation of the presence of antigen and the group with the presence of viral antigen without any signs of inflammation in the myocardium.

The study is nonrandomized.

Undersøgelsestype

Interventionel

Tilmelding (Forventet)

60

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Den Russiske Føderation
      • Tomsk, Den Russiske Føderation, 634012
        • Rekruttering
        • Scientific and Research Institution of Cardiology of Siberian Department of RAMS
        • Ledende efterforsker:
          • Vyacheslav Ryabov, MD, PhD
        • Kontakt:
    • Tomskii region
      • Tomsk, Tomskii region, Den Russiske Føderation, 634012
        • Rekruttering
        • Research Institutite for Cardiology
        • Kontakt:
        • Ledende efterforsker:
          • Vyacheslav Ryabov, MD, PhD

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 75 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Men and women over the age of 18 years old and weighing up to 130 kg
  • Clinical symptoms of decompensated heart failure in history
  • Heart failure decompensation requiring hospitalization for at least 3 of the following symptoms: shortness of breath, or position orthopnea, rales, peripheral edema, jugular venous pulsations, signs of stagnation in the pulmonary circulation according to the X-ray of the chest
  • Confirmed coronary heart disease with diastolic dysfunction (LVEF <40%) in history and at the time of admission
  • The term of the inclusion of patients in the study did not earlier than six months after revascularization (PCI or CABG)
  • Patients receiving medical treatment according to national guidelines RSC and ESC with individually tailored doses of drugs

Exclusion Criteria:

  • The refusal of a patient to conduct the necessary studies
  • Poor visualization of the heart when ultrasound
  • Hemodynamically significant valvular heart disease
  • Acute coronary syndrome
  • Тhrombosis of the right atrium and right ventricle
  • Condition after the operation, impeding access to the right ventricle (cava filters plication vena cava, Mustard or Senning operation on the d-transposition of the great arteries, a mechanical prosthetic tricuspid valve)
  • Severe comorbidities

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Diagnostisk
  • Tildeling: N/A
  • Interventionel model: Enkelt gruppeopgave
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Andet: chronic inflammation
All patients will be held PCI to exclude ischemic heart failure decompensation. Also, all patients will be performed endomyocardial biopsy.
Procedure: Endomyocardial biopsy
Endomyocardial biopsy will be performed through a puncture in the femoral vein. 3-6 samples taken under the control of myocardial echocardiography or flyuroskopii. Samples of biopsy material then transmitted Pathomorphology for immunohistochemistry, light microscope.
Andre navne:
  • EMB

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
Incidence of inflammatory infiltrate in the myocardial tissue
Tidsramme: 6 month after PCI or CABG
6 month after PCI or CABG

Sekundære resultatmål

Resultatmål
Tidsramme
Incidence of the virus - positive inflammatory infiltrate in the myocardial tissue
Tidsramme: 6 month after PCI or CABG
6 month after PCI or CABG
The most frequent viral agents in myocardial tissue in this region
Tidsramme: 6 month after PCI or CABG
6 month after PCI or CABG
Incidence of the acute myocardial infarction
Tidsramme: 6 and 12 month after PCI or CABG
6 and 12 month after PCI or CABG
Incidence of disturbance rhythm and conduction of the heart
Tidsramme: 6 and 12 month after PCI or CABG
6 and 12 month after PCI or CABG
Left ventricular ejection fraction (Echo)
Tidsramme: 6 and 12 month after PCI or CABG
6 and 12 month after PCI or CABG
Еnd-diastolic volume of the left ventricle (Echo)
Tidsramme: 6 and 12 month after PCI or CABG
6 and 12 month after PCI or CABG
Еnd-systolic volume of the left ventricle (Echo)
Tidsramme: 6 and 12 month after PCI or CABG
6 and 12 month after PCI or CABG
Incidence of the mortality
Tidsramme: 6 and 12 month after PCI or CABG
6 and 12 month after PCI or CABG
Incidence of the stroke
Tidsramme: 6 and 12 month after PCI or CABG
6 and 12 month after PCI or CABG
Incidence of hospitalizations for decompensation heart failure
Tidsramme: 6 and 12 month after PCI or CABG
6 and 12 month after PCI or CABG

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Russian Academy of Medical Sciences

Efterforskere

  • Ledende efterforsker: Vyacheslav Ryabov, MD, PhD, Research Institute for Cardiology

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. januar 2016

Primær færdiggørelse (Forventet)

1. februar 2018

Studieafslutning (Forventet)

1. oktober 2018

Datoer for studieregistrering

Først indsendt

4. januar 2016

Først indsendt, der opfyldte QC-kriterier

5. januar 2016

Først opslået (Skøn)

7. januar 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

7. januar 2016

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

5. januar 2016

Sidst verificeret

1. januar 2016

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 1801

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Iskæmisk hjertesygdom

Kliniske forsøg med Endomyocardial biopsy

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Burkina Faso

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Abonner