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Effect of Early Antiviral Therapy on Duration of Cough in Flu Patients

4. august 2018 opdateret af: HuKe, Renmin Hospital of Wuhan University
This study mainly focused on the effect of early antiviral treatment on the duration of cough in influenza patients.investigators conducted an early investigation of patients with positive influenza virus and asked whether patients used antiviral drugs in the early stages. According to the use of drugs, patients were divided into oral oseltamivir group, oral lotus phlegm group and other groups, and investigators will collected Inspection information and medication status,during the treatment period of patients.

Studieoversigt

Status

Ukendt

Detaljeret beskrivelse

Cough is a common symptom of respiratory diseases and helps to clear respiratory secretions and harmful factors, but frequent severe coughing has a serious impact on the patient's work, life and social activities. Upper respiratory tract viral infection is a common cause of coughing. Many patients have a long duration of cough after suffering from flu. Cough can last for several weeks, and most often have irritating dry cough or a small amount of white mucus sputum. This type of cough is also often referred to as "subacute cough" or "post-infection cough." The mechanisms that cause this cough have not been fully elucidated, and the effect of conventional treatment is not good, and chest imaging has no obvious abnormalities. The use of large amounts of antibiotics is ineffective or ineffective. Antihistamine H1 receptor antagonists and central antitussives are often only effective or ineffective in the short term. The effects of various bronchodilators and even hormone drugs are not clear. Due to the poor efficacy of multiple treatments, patients are repeatedly subjected to various tests, which not only increases the pain but also aggravates the economic burden.

Therefore, it is necessary to further clarify the causes and treatment measures of post-influenza cough patients.

Undersøgelsestype

Observationel

Tilmelding (Forventet)

120

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

    • Hubei
      • Wuhan, Hubei, Kina, 430060
        • Renmin Hospital of Wuhan University

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 70 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Prøveudtagningsmetode

Sandsynlighedsprøve

Studiebefolkning

Flu patients who were diagnosed in our hospital from April 2018 to July 2019

Beskrivelse

Inclusion Criteria:

For patients with flu-free flu, cough for at least one week.

  1. In line with the flu etiological diagnostic criteria: According to the guidelines set by the National Health and Health Committee, the diagnosis is based on etiological screening methods or confirmed methods; ages 18 to 70 years.
  2. There are no influenza complications such as acute lower respiratory tract infection, tonsillitis, sinusitis, otitis media, myocarditis, etc.
  3. It is usually healthy and there are no chronic underlying diseases such as hypertension and diabetes.
  4. Treating with cough as the main symptom, the cough lasts for at least one week and the chest radiograph is normal.
  5. Signed informed consent.

Exclusion Criteria:

  1. Suspected flu patients who have not received the flu etiology test;
  2. There is a clear comorbid disease (combined with other sites of acute bacterial or viral infections);
  3. There is a clear cough caused by other reasons;
  4. With severe liver and kidney dysfunction;
  5. Pregnant women.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Oral oseltamivir group
Patients with influenza virus positive and early oral oseltamivir capsules
Oral Lotus Capsules group
Patients with positive influenza virus and early oral administration of lotus extract capsules
other group
Influenza virus positive patients who were not treated with oral lotus capsule or oseltamivir capsules early

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Cough duration
Tidsramme: 6 months
Investigators will follow up every other week for follow-up calls or outpatients to ask about cough and medication, until the patient stops coughing, cough lasts from 1 day to 12 weeks, and cough time is greater than 12 weeks. Investigators should seriously exclude cough caused by other factors. No other factors are still included in the study, and the maximum time is no more than 6 months. If there are other factors causing cough, it will not be included in the study.
6 months

Samarbejdspartnere og efterforskere

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Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Forventet)

1. september 2018

Primær færdiggørelse (Forventet)

1. september 2019

Studieafslutning (Forventet)

1. december 2019

Datoer for studieregistrering

Først indsendt

4. juli 2018

Først indsendt, der opfyldte QC-kriterier

4. august 2018

Først opslået (Faktiske)

7. august 2018

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

7. august 2018

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

4. august 2018

Sidst verificeret

1. juli 2018

Mere information

Begreber relateret til denne undersøgelse

Plan for individuelle deltagerdata (IPD)

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Kliniske forsøg med Influenzavirusinfektion

3
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