Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Respiratory Pathogen Distribution During and After the COVID-19 Pandemic

20. maj 2026 opdateret af: Bekir Sami Uyanık, Hisar Intercontinental Hospital

Comparative Analysis of Respiratory Pathogens During and After the SARS-CoV-2 Pandemic: A Retrospective Multiplex PCR-Based Study

This retrospective observational study aims to evaluate changes in the prevalence and distribution of respiratory pathogens detected by multiplex respiratory polymerase chain reaction (PCR) testing during and after the SARS-CoV-2 pandemic. The study includes 537 patients presenting with respiratory infection symptoms at a tertiary care center. Patients were divided into pandemic-period and post-pandemic-period groups, and respiratory pathogen profiles were compared between the groups.

The study investigates the epidemiological impact of COVID-19-related public health measures on respiratory pathogen circulation patterns, including bacterial and viral respiratory infections. The findings may contribute to improved respiratory infection surveillance, diagnostic strategies, and post-pandemic public health preparedness.

Studieoversigt

Status

Afsluttet

Betingelser

Detaljeret beskrivelse

The COVID-19 pandemic significantly altered the epidemiology of respiratory infections worldwide. Non-pharmaceutical interventions (NPIs), including mask use, social distancing, travel restrictions, enhanced hygiene measures, and lockdown policies, were implemented primarily to reduce SARS-CoV-2 transmission. However, these interventions also affected the circulation patterns of other respiratory pathogens.

Several studies have demonstrated substantial reductions in influenza, respiratory syncytial virus (RSV), and other respiratory viral infections during periods of strict public health measures. Following the relaxation of these interventions, many regions experienced re-emergence and altered seasonal patterns of respiratory pathogens. Continuous surveillance of respiratory infections has therefore become increasingly important for both clinical management and public health preparedness.

This retrospective observational cohort study aims to evaluate changes in respiratory pathogen prevalence during and after the SARS-CoV-2 pandemic using multiplex respiratory PCR testing data obtained from patients presenting with respiratory infection symptoms at a tertiary care center. A total of 537 patients were included and categorized into pandemic-period and post-pandemic-period groups.

Demographic characteristics and multiplex PCR results were analyzed and compared between the groups. Respiratory pathogens evaluated in the study included bacterial and viral agents such as Streptococcus pneumoniae, Haemophilus influenzae, Influenza A/B, SARS-CoV-2, RSV, Rhinovirus, Bocavirus, Parainfluenza virus, Coronavirus, and Metapneumovirus.

The study aims to contribute to understanding the long-term epidemiological effects of the COVID-19 pandemic and associated public health measures on respiratory pathogen distribution. In addition, the findings may support future infection surveillance strategies, diagnostic approaches, and healthcare preparedness in post-pandemic periods.

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

537

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn
  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

The study population consisted of patients presenting with respiratory infection symptoms who underwent multiplex respiratory polymerase chain reaction (PCR) testing at a tertiary care center during the pandemic and post-pandemic periods. Patients with complete demographic and laboratory data were included in the analysis.

Beskrivelse

Inclusion Criteria:

  • Adults and/or pediatric patients presenting with respiratory infection symptoms
  • Patients who underwent multiplex respiratory PCR testing
  • Patients with complete demographic and laboratory records
  • Patients included during the defined pandemic or post-pandemic study periods

Exclusion Criteria:

  • Incomplete laboratory or demographic data
  • Duplicate test records from the same infection episode
  • Invalid or inconclusive PCR results
  • Patients without respiratory infection symptoms

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Pandemic Period Group
Patients presenting with respiratory infection symptoms who underwent multiplex respiratory PCR testing during the SARS-CoV-2 pandemic period.
Post-Pandemic Period Group
Patients presenting with respiratory infection symptoms who underwent multiplex respiratory PCR testing during the post-pandemic normalization period.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Change in the prevalence of respiratory pathogens between the pandemic and post-pandemic periods
Tidsramme: Retrospectively assessed at the time of respiratory PCR testing during the study periods. Pandemic period: March 2020 - May 2023 Post-pandemic period: June 2023 - December 202
The primary outcome is the difference in detection rates of respiratory pathogens identified by multiplex respiratory PCR testing between the SARS-CoV-2 pandemic period and the post-pandemic period.
Retrospectively assessed at the time of respiratory PCR testing during the study periods. Pandemic period: March 2020 - May 2023 Post-pandemic period: June 2023 - December 202

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Hisar Intercontinental Hospital

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. januar 2021

Primær færdiggørelse (Faktiske)

30. december 2024

Studieafslutning (Faktiske)

30. december 2024

Datoer for studieregistrering

Først indsendt

13. maj 2026

Først indsendt, der opfyldte QC-kriterier

20. maj 2026

Først opslået (Faktiske)

22. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

22. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

20. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • HHI-RP-PCR-2026-001

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

IPD-planbeskrivelse

Individual participant data (IPD) will not be shared because this retrospective study contains hospital-based patient data, and sharing such data may compromise patient confidentiality and institutional data protection policies.

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Bakterielle luftvejsinfektioner

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Poland

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Abonner