- ICH GCP
- US-Register für klinische Studien
- Klinische Studie NCT00005333
Epidemic Hypertension in Nigerian Workers
Studienübersicht
Status
Bedingungen
Detaillierte Beschreibung
BACKGROUND:
This dynamic population provided a valuable opportunity to gain important information about the etiology of hypertension which would be much more difficult to gain from a United States Black population because higher weight and blood pressure are already entrenched and static in the United States population.
DESIGN NARRATIVE:
From 1991 to 1996, a cross-sectional study was conducted to test the hypothesis that differences in hypertension prevalence were primarily related to differences in SES. The higher prevalence of hypertension among the high SES Nigerian professionals was thought to be related to higher weight, caloric intake, Westernization of diet, alcohol intake, sodium intake, cardiovascular reactivity, and stress due to job, migration, and change in SES, and to reduced potassium intake and physical activity. Civil servants were systematically sampled from civil service employee lists. Data were collected on blood pressure; urinary sodium, potassium, and protein; diet; anthropometry; electrocardiogram; serum insulin; stress in the work environment, migration history, and cardiovascular reactivity.
In FY 1992, the Office of Research on Women's Health provided supplemental funds to enlarge the study and to perform gender analyses. The supplemental funds were used to determine whether fatty acid distributions, and their relationships to cardiovascular risk factors differed between Nigerian women and United States Black women; United States Black women and United States white women; and Nigerian women and Nigerian men. Forty men and forty women, ages 18 to 30, were chosen randomly from the Nigerian civil servant population. Subjects with hypertension, those using oral contraceptives, or any medication affecting the sympathetic nervous system, were excluded. The Nigerian subjects were compared with 40 Black and 40 white healthy female volunteers at the University of Pittsburgh.
The grant was renewed in 1996 through August 2001 to conduct a longitudinal study of 726 members of the original cohort. The purpose was to determine the importance of weight gain and weight-related factors, and the possible interaction of other factors, e.g. psychosocial, electrolytes, reactivity, macronutrient intake, to change in blood pressure. Factors related to weight gain were identified. The high prevalence of the electrocardiogram left ventricular hypertrophy (ECG-LVH) was validated against echocardiographic measures (ECHO-LVH). Predictors of change in ECG-LVH, and the correlates of microalbuminuria were identified. In Year 2 (Cohort Year 4) half of the population was restudied with echocardiography, cardiovascular reactivity, and new psychosocial measures. In Year 4 (Cohort Year 6), with the exception of cardiovascular reactivity, the full cohort was re-examined for baseline measures, including multiple blood pressure readings, height, weight, waist, hips, ECG, physical activity, two 24 hour dietary recalls, alcohol intake, menopausal status, psychosocial measures, 24 hour urine for sodium, potassium, creatinine, micro-albuminuria, and fasting serum for lipids, insulin, glucose, and creatinine.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Studientyp
Teilnahmekriterien
Zulassungskriterien
Studienberechtigtes Alter
Akzeptiert gesunde Freiwillige
Studienberechtigte Geschlechter
Beschreibung
Studienplan
Wie ist die Studie aufgebaut?
Mitarbeiter und Ermittler
Ermittler
- Clareann Bunker, University of Pittsburgh
Publikationen und hilfreiche Links
Allgemeine Veröffentlichungen
- Evans RW, Bunker CH, Ukoli FA, Kuller LH. Lipoprotein (a) distribution in a Nigerian population. Ethn Health. 1997 Mar-Jun;2(1-2):47-58. doi: 10.1080/13557858.1997.9961814.
- Yeh LL, Kuller LH, Bunker CH, Ukoli FA, Huston SL, Terrell DF. The role of socioeconomic status and serum fatty acids in the relationship between intake of animal foods and cardiovascular risk factors. Ann Epidemiol. 1996 Jul;6(4):290-8. doi: 10.1016/s1047-2797(96)00023-3.
- Bunker CH, Ukoli FA, Okoro FI, Olomu AB, Kriska AM, Huston SL, Markovic N, Kuller LH. Correlates of serum lipids in a lean black population. Atherosclerosis. 1996 Jun;123(1-2):215-25. doi: 10.1016/0021-9150(96)05810-8.
- Markovic N, Matthews KA, Huston SL, Egbagbe E, Ukoli FA, Bunker CH. Blood pressure reactivity to stress varies by hypertensive status and sex in Nigerians. Am J Epidemiol. 1995 Nov 15;142(10):1020-8. doi: 10.1093/oxfordjournals.aje.a117554.
- Bunker CH, Ukoli FA, Matthews KA, Kriska AM, Huston SL, Kuller LH. Weight threshold and blood pressure in a lean black population. Hypertension. 1995 Oct;26(4):616-23. doi: 10.1161/01.hyp.26.4.616.
- Ukoli FA, Bunker CH, Fabio A, Olomu AB, Egbagbe EE, Kuller LH. Body fat distribution and other anthropometric blood pressure correlates in a Nigerian urban elderly population. Cent Afr J Med. 1995 May;41(5):154-61.
- Markovic N, Olomu IN, Bunker CH, Huston SL, Ukoli FA, Kuller LH. Adequacy of a single visit for classification of hypertensive status in a Nigerian civil servant population. Int J Epidemiol. 1994 Aug;23(4):723-9. doi: 10.1093/ije/23.4.723.
- Huston SL, Bunker CH, Ukoli FA, Rautaharju PM, Kuller LH. Electrocardiographic left ventricular hypertrophy by five criteria among civil servants in Benin City, Nigeria: prevalence and correlates. Int J Cardiol. 1999 Jul 1;70(1):1-14. doi: 10.1016/s0167-5273(99)00061-3.
- Markovic N, Bunker CH, Ukoli FA, Kuller LH. John Henryism and blood pressure among Nigerian civil servants. J Epidemiol Community Health. 1998 Mar;52(3):186-90. doi: 10.1136/jech.52.3.186.
- Desai PP, Bunker CH, Ukoli FA, Kamboh MI. Genetic variation in the apolipoprotein D gene among African blacks and its significance in lipid metabolism. Atherosclerosis. 2002 Aug;163(2):329-38. doi: 10.1016/s0021-9150(02)00012-6.
- Forrest KY, Bunker CH, Kriska AM, Ukoli FA, Huston SL, Markovic N. Physical activity and cardiovascular risk factors in a developing population. Med Sci Sports Exerc. 2001 Sep;33(9):1598-604. doi: 10.1097/00005768-200109000-00025.
Studienaufzeichnungsdaten
Haupttermine studieren
Studienbeginn
Studienabschluss (Tatsächlich)
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst gepostet (Schätzen)
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Schätzen)
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Zuletzt verifiziert
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Zusätzliche relevante MeSH-Bedingungen
Andere Studien-ID-Nummern
- 4188
- R01HL044413 (US NIH Stipendium/Vertrag)
Diese Informationen wurden ohne Änderungen direkt von der Website clinicaltrials.gov abgerufen. Wenn Sie Ihre Studiendaten ändern, entfernen oder aktualisieren möchten, wenden Sie sich bitte an register@clinicaltrials.gov. Sobald eine Änderung auf clinicaltrials.gov implementiert wird, wird diese automatisch auch auf unserer Website aktualisiert .
Klinische Studien zur Herzkrankheiten
-
Region SkaneAnmeldung auf EinladungHerzinsuffizienz New York Heart Association (NYHA) Klasse II | Herzinsuffizienz New York Heart Association (NYHA) Klasse IIISchweden
-
Medical University of BialystokInstitute of Cardiology, Warsaw, Poland; Medical University of Lodz; Poznan University... und andere MitarbeiterNoch keine RekrutierungHerzinsuffizienz, systolisch | Herzinsuffizienz mit reduzierter Ejektionsfraktion | Herzinsuffizienz New York Heart Association Klasse IV | Herzinsuffizienz New York Heart Association Klasse IIIPolen
-
University of WashingtonAmerican Heart AssociationAbgeschlossenHerzinsuffizienz, kongestive | Mitochondriale Veränderung | Herzinsuffizienz New York Heart Association Klasse IVVereinigte Staaten
-
Abbott Medical DevicesThoratec CorporationAbgeschlossenDriveline Heart-assisted Device Related InfectionVereinigte Staaten
-
Medical University of South CarolinaAmerican Heart AssociationAbgeschlossenSingle Ventricle Heart Disease nach Fontan-OperationVereinigte Staaten
-
Mezzion Pharma Co. LtdNational Heart, Lung, and Blood Institute (NHLBI); Pediatric Heart NetworkAbgeschlossenSingle Ventricle Heart Disease nach Fontan-OperationVereinigte Staaten, Kanada
-
University Hospital, GasthuisbergUnbekanntTransient Left Ventricular Ballooning SyndromeBelgien
-
NYU Langone HealthRekrutierungTako-Tsubo-Kardiomyopathie | Takotsubo-Kardiomyopathie | Broken-Heart-SyndromVereinigte Staaten
-
French Cardiology SocietyAbgeschlossen