Safety, Tolerability and Pharmacokinetics of AUT00206 in Patients With Schizophrenia, and Also Explores the Effects of AUT00206 on Relevant Central Biomarkers.

Key inclusion Criteria:

• Male patients with a diagnosis of schizophrenia no more than 5 calendar years (before screening);
• Positive and negative symptoms assessed by PANSS;
• Medically and psychiatrically stable;
• On a stable dose of antipsychotic drugs;
• Able to give fully informed written consent and likely to comply with the requirements of the trial.

Key exclusion Criteria:

• clinically relevant, as assessed by a physician, abnormal findings at the screening assessment;
• sensitivity to excipients of the trial medication;
• current use of contraindicated drugs;
• participation in another clinical trial of unlicensed medicines within the previous 30 days;
• loss of more than 400 mL blood, within the previous 3 months; history of drug or alcohol dependence in the last year;
• significant acute or chronic illness;
• significant medical history or concurrent medical condition that warrants exclusion;
• objection by subject's physician