- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT02913820
Association of Snowfall and Myocardial Infarction
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of air temperature (changes) or humidity are of potential relevance. In addition, exercise and the associated increase in oxygen demand of the myocardium and blood pressure is another trigger for plaque rupture and the acute onset of myocardial infarction. Male patients as well as patients with previous coronary heart disease or little regular exercise are at increased risk.
Possible additional mechanisms of exercise induced myocardial infarction are vasospasm and changes in blood clotting.
Changes in the ambient temperature (warm to cold) can also induce vasospasm which might result in reduced perfusion and plaque rupture. It seems that male patients are more involved than female patients.
Taking the exercise and the ambient temperature changes into consideration, heavy snowfall with consecutive snow shoveling is an augmented risk for acute myocardial infarction.
The rationale of the study is to test if the above mentioned constellation of environmental factors as well as potential increased exercise have a significant and independent impact on the incidence of myocardial infarctions
Type d'étude
Inscription (Réel)
Contacts et emplacements
Lieux d'étude
-
-
-
Graz, L'Autriche, 8010
- Medical University of Graz
-
-
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
Méthode d'échantillonnage
Population étudiée
La description
Inclusion Criteria:
- myocardial infarction being confirmed or treated in the cathlab
Exclusion Criteria:
- none
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Modèles d'observation: Cohorte
- Perspectives temporelles: Rétrospective
Cohortes et interventions
Groupe / Cohorte |
Intervention / Traitement |
---|---|
snowfall >5cm/d
impact of snowfall and its correlation with acute myocardial infarctions is analyzed.
Other precipitation (rainfall) changes in atmospheric pressure and temperature will be variables to be corrected for.
|
the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of snowfall
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
myocardial infarction
Délai: 1 day
|
the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of snowfall
|
1 day
|
Collaborateurs et enquêteurs
Parrainer
Publications et liens utiles
Publications générales
- Burke AP, Farb A, Malcom GT, Liang Y, Smialek JE, Virmani R. Plaque rupture and sudden death related to exertion in men with coronary artery disease. JAMA. 1999 Mar 10;281(10):921-6. doi: 10.1001/jama.281.10.921.
- Chevalier L, Hajjar M, Douard H, Cherief A, Dindard JM, Sedze F, Ricard R, Vincent MP, Corneloup L, Gencel L, Carre F. Sports-related acute cardiovascular events in a general population: a French prospective study. Eur J Cardiovasc Prev Rehabil. 2009 Jun;16(3):365-70. doi: 10.1097/HJR.0b013e3283291417.
- Gordon JB, Ganz P, Nabel EG, Fish RD, Zebede J, Mudge GH, Alexander RW, Selwyn AP. Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise. J Clin Invest. 1989 Jun;83(6):1946-52. doi: 10.1172/JCI114103.
- van Teeffelen WM, de Beus MF, Mosterd A, Bots ML, Mosterd WL, Pool J, Doevendans PA, Grobbee DE. Risk factors for exercise-related acute cardiac events. A case-control study. Br J Sports Med. 2009 Sep;43(9):722-5. doi: 10.1136/bjsm.2009.057307.
- Willich SN, Lewis M, Lowel H, Arntz HR, Schubert F, Schroder R. Physical exertion as a trigger of acute myocardial infarction. Triggers and Mechanisms of Myocardial Infarction Study Group. N Engl J Med. 1993 Dec 2;329(23):1684-90. doi: 10.1056/NEJM199312023292302.
- Giri S, Thompson PD, Kiernan FJ, Clive J, Fram DB, Mitchel JF, Hirst JA, McKay RG, Waters DD. Clinical and angiographic characteristics of exertion-related acute myocardial infarction. JAMA. 1999 Nov 10;282(18):1731-6. doi: 10.1001/jama.282.18.1731. Erratum In: JAMA 1999 Dec 8;282(22):2124.
- Ciampricotti R, el Gamal MI, Bonnier JJ, Relik TH. Myocardial infarction and sudden death after sport: acute coronary angiographic findings. Cathet Cardiovasc Diagn. 1989 Aug;17(4):193-7. doi: 10.1002/ccd.1810170402.
- Janardhanan R, Henry Z, Hur DJ, Lin CM, Lopez D, Reagan PM, Rudnick SR, Koshko TJ, Keeley EC. The snow-shoveler's ST elevation myocardial infarction. Am J Cardiol. 2010 Aug 15;106(4):596-600. doi: 10.1016/j.amjcard.2010.03.075.
- Nitenberg A, Chemla D, Antony I. Epicardial coronary artery constriction to cold pressor test is predictive of cardiovascular events in hypertensive patients with angiographically normal coronary arteries and without other major coronary risk factor. Atherosclerosis. 2004 Mar;173(1):115-23. doi: 10.1016/j.atherosclerosis.2003.12.030.
- Thompson DR, Pohl JE, Tse YY, Hiorns RW. Meteorological factors and the time of onset of chest pain in acute myocardial infarction. Int J Biometeorol. 1996 Sep;39(3):116-20. doi: 10.1007/BF01211222.
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- EK28-433ex15/16
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .
Essais cliniques sur snowfall > 5cm/day
-
Vanderbilt UniversityComplétéInhibition neuromusculaireÉtats-Unis
-
Johnson & Johnson Vision Care, Inc.Complété
-
University of HoustonComplétéÉpithéliopathie d'essuie-glaceÉtats-Unis
-
Massachusetts General HospitalAmerican Cancer Society, Inc.Résilié
-
Karolinska InstitutetRegion Stockholm; ForteActif, ne recrute pasAccident vasculaire cérébral | Maladie non transmissibleSuède
-
University of Nevada, Las VegasRecrutementTBI (Traumatisme Cérébral) | Exercer | Commotion cérébrale | Réhabilitation | Marche | Cognition | Essai clinique | Fonctionnement psychosocial | microARN | Application mobile | Salive | Vision, OculaireÉtats-Unis
-
Heidelberg UniversityHector-Stiftung; Schwabe-Wenex International Ltd; Cefak KG, Kempten; Ursapharm...Complété
-
Unilever R&DWorld Dental Federation (FDI)ComplétéLa plaque dentaire | Comportement | Comportement, SantéIndonésie, Nigeria
-
Johnson & Johnson Vision Care, Inc.RecrutementAcuité visuelleÉtats-Unis
-
University of Wisconsin, MadisonUrban League of Greater Madison; African American Council of Churches Madison et autres collaborateursComplétéLa dépression | Autogestion | ConscienceÉtats-Unis