Endothelium, Stenting, and Antiplatelet Therapy (EST) - Clopidogrel, Prasugrel, Ticagrelor Study (EST)

Inclusion Criteria:

• - 18-75 years old consecutive patients undergoing coronary angiography and stenting at the University Medical Centre Mainz
• A coronary lesion (and patient) amenable to treatment with drug eluting stent
• Ability of subject to understand character and individual consequences of clinical trial
• Signed and dated informed consent of the subject must be available before start of any specific trial procedures.
• Negative pregnancy test of women with childbearing potential

Exclusion Criteria:

• Subjects presenting 1 or more of the following criteria will not be enrolled in the trial:
• Patients with elevated (> 5 times upper normal limit) C-reactive protein level prior to stenting
• Patients in whom therapy with long-acting nitrates cannot be suspended prior to endothelial function measurements
• An acute coronary syndrome treated with coronary stenting within the last 4 weeks
• Patients with known inflammatory/infective diseases
• Patients with severe extracardiac diseases limiting life expectancy
• Known heart failure (LV-EF ≤ 40% AND NYHA III-IV)
• PCI or coronary By-Pass surgery within the last 4 weeks, pre-existing ongoing treatment with any of the study treatments.
• History of cerebrovascular events (stroke)
• Known renal dysfunction (serum creatinine ≥ 1.8mg/dl in women, ≥ 2.0mg/dl in men)
• Serum potassium > 5.5mmol/l
• Known hepatic impairment (AST, ALT > 3 times upper limit of normal)
• Changes in the ß-blocker, statin or ACE or angiotensin-receptor blocker inhibitor treatment within the past 2 weeks
• Pregnancy and lactation, inadequate contraception
• Body weight < 60kg
• Active bleeding
• Therapy with CYP3A4 inhibitors (ketoconazole, protease inhibitors, macrolide antibiotics)
• Therapy with anticoagulants: phenprocoumone, warfarin, dabigatran, rivaroxaban
• History of hypersensitivity to any of the investigational medicinal products or to any drug with similar chemical structure or to any excipient present in the pharmaceutical form of the investigational medicinal product.
• Ongoing participation in other clinical trials or within the last 3 months, or ongoing therapy with one of the study medications.
• Medical or psychological condition that would not permit completion of the trial or signing of informed consent.
• Patients with acute ST-elevation myocardial infarction