- ICH GCP
- Registro degli studi clinici negli Stati Uniti
- Sperimentazione clinica NCT03858010
Personalised Outcomes in Children With Recurrent Wheeze
Validation of a Patient-reported Outcome Measurement Tool
This project aims to develop a PROM for preschool children with recurrent wheeze. Nearly one third of children will have at least one episode of wheeze in the first five years of life. The majority of these children grow out of the condition in early school years. However, their families go through challenging times often with numerous emergency department admissions and hospitalizations. Hospital admission rates for preschool children with wheeze attacks remain high and are increasing in the UK. New treatments have become available, but although current treatments speed recovery from a wheeze attack, still many children visit hospitals for rescue medications and medical reviews. Recent Australian data show that one fourth of these children remain at emergency departments for a less than four hours period, suggesting that with better information and education, these children could have remained at home.
Justification-Significance of the work By understanding what really matters for these families, clinicians and stakeholders will be better able to design interventions that will reduce the hospital attendances and admissions by empowering parents to manage their children's condition. More specifically, this tool will assist GPs identify which of these children need to be reviewed by specialists, aid holistic management, ensure interventions are meaningful for families and assess the benefits of novel treatments.
Methodology The items of the questionnaire have been generated through discussions with families in a qualitative research study conducted by the research team. These items will be refined and the questionnaire will be tested with families in different healthcare settings. Researchers will assess how well this questionnaire is identifying the children who present with greater number of hospital admissions and will be benefited from suggested interventions. The data will be analysed and based on the results, amendments will be made to the questionnaire, which can will then be introduced in the routine management of these children.
Panoramica dello studio
Stato
Condizioni
Intervento / Trattamento
Descrizione dettagliata
The validation of the tool will take place at St Mary's Hospital.
The questionnaire aims to measure
- incidence of wheeze attacks and use of rescue medications
- parental/caregiver perception of recurrent wheeze control
- parental/caregiver perception of effect of recurrent wheeze on family/child quality of life
Participants will be given the questionnaire at the emergency departments or outpatients clinics following having consented to the study and will be asked to fill in the questionnaire and return it to their clinician.
Tipo di studio
Iscrizione (Anticipato)
Contatti e Sedi
Contatto studio
- Nome: Heidi Makrinioti
- Numero di telefono: 07771348633
- Email: heidimakrinioti@gmail.com
Luoghi di studio
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London, Regno Unito, W2 1NY
- Reclutamento
- St Mary's Hospital
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Contatto:
- ChaidoNiki Makrynioti, PhD
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Criteri di partecipazione
Criteri di ammissibilità
Età idonea allo studio
Accetta volontari sani
Sessi ammissibili allo studio
Metodo di campionamento
Popolazione di studio
Descrizione
Inclusion Criteria:
In this study caregivers of preschool children presenting with the second or more episode of wheeze that requires physician review with or without treatment (as per BTS definition of wheeze attack in preschool years) will be included.
Exclusion Criteria:
This study will exclude caregivers who do not consent to complete the questionnaire and therefore participate in the study.
This study will exclude caregivers of preschool children who present with their first episode of wheeze.
This study will exclude caregivers of preschool children who present with respiratory distress of any other etiology (foreign body inhalation, croup, lower respiratory tract infection, bronchiectasis, exacerbation of cystic fibrosis or ciliopathy)
Piano di studio
Come è strutturato lo studio?
Dettagli di progettazione
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
---|---|---|
feasibility of preschool wheeze assessment tool
Lasso di tempo: March 2019 - March 2020
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how easily the questionnaire can be completed
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March 2019 - March 2020
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content validity of the questionnaire
Lasso di tempo: March 2019-March 2020
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assessing validity of each item of the questionnaire as comparing with item of already existing questionnaire
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March 2019-March 2020
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Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
---|---|---|
reduction of avoidable emergency department admissions
Lasso di tempo: March 2020-March 2021
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effect of the tool on number of avoidable emergency department presentations
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March 2020-March 2021
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Collaboratori e investigatori
Investigatori
- Investigatore principale: Mando Watson, Imperial College Healthcare NHS Trust
Pubblicazioni e link utili
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Inizio studio (Effettivo)
Completamento primario (Anticipato)
Completamento dello studio (Anticipato)
Date di iscrizione allo studio
Primo inviato
Primo inviato che soddisfa i criteri di controllo qualità
Primo Inserito (Effettivo)
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
Ultimo aggiornamento inviato che soddisfa i criteri QC
Ultimo verificato
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- 226984
Piano per i dati dei singoli partecipanti (IPD)
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Descrizione del piano IPD
Informazioni su farmaci e dispositivi, documenti di studio
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