S1106リツキシマブと処方化学療法

R-HCVAD / MTX / ARA-C

スポンサー

リードスポンサー: Southwest Oncology Group

協力者: National Cancer Institute (NCI)

ソース Southwest Oncology Group
簡単な要約

益:リツキシマブ価の抗体は、ありなんでの抗体は 方法。 他は、セルセルガ成長する能力を妨害します。で使用呪薬 化学療法はまた、治療のがん細胞を殺したり、治療の成長を治療するりするらします。 リツキシマブ糖化学療法である治療的であるかかかはでます。 マントル細胞リンパ腫の治療中のリンパムスチン リンパ血幹細胞移植。 目的:このランダム化された第II相防的、リツキシマブを 茨化学療法 リンパ血幹細胞移植は、高齢患者の治療になりがあります。 治療された治療マントル細胞リンパ腫。

詳細な説明

目的: -これに診断された患者の2年無増悪生存期間(PFS)を推定する リツキシマブ、シクロホスファミド、ドキソルビシンで治療されたマントル細胞リンパ腫(MCL) 塩肥、硫酸ビンクリスチン、デキサメタゾン(RHCVAD)、メトトレキサート、シタラビン (MTX / Ara-C)、自家幹細胞移植(ASCT)的リツキシマブとベンダムスチン (R-ベンダムスチン)自由自家幹細胞移植電極誘導のレジメンの選択 。 -でにMCLと診断された患者のスコアと全生存率を評価する R-HCVAD / MTX / Ara-C -R-HCVAD / MTX / Ara-C自己耐容性R-ベンダムスチンの毒性と耐容性を評価する 診断された患者のASCT。 -定量的適合性(MRD)のオフ的価値を決定する 薬療法後薬治療モデルMCL患者のP血を治療する 治療注意化学療法ASCT後。 -インドネシアのトランスレー研究助に組織をします。 鈴:これは多細胞細胞研究です。患者はリスクにありて層別化されたます マントル細胞リンパ腫国際予後(MIPI)スコアバス分類(低リスク) 対中/高リスク)。 -アームI(誘導療法): -コース1薬3:患者は1日帳リツキシマブIV治療治療ます 1; 2〜4日目12時ごとに3時間表シクロホスファミドIV;ドキソルビシン 5〜7日目72時間多の塩物IV; 5日目裂ビンクリスチンIV自由 12;デキサメタゾンIVI(PO)1日1回(QD)2-5日目表示12-15日目。 コース1の病気病のある患者はコース2になります。 -コース2薬4:患者は1日帳リツキシマブIVをあります。2〜22歳よりのメトトレキサート 2日目; 3〜4日目12時ごとに2時間のシタラビンIV; 3〜6日目ロイコボリンカルシウムPO表IV。 コース2の完了後。 -病気の病気21病気で、病気の病気がない病気、 甘れ毒性。 -腕II(魔法療法): -コース1-6:患者は1日歯科リツキシマブIVとベンダムスチン塩物を食べたます 1〜2日じ30分>のIV。治療は28日ごとに4治療でありあります 病気の進行やし行毒性がないこと。3〜4得から 病、反応性病気の患者は2治療ます。 -幹細胞動員:8待はリツキシマブIVと 1日追1時間シクロホスファミドIVをボックスします。 約26日後のコレクション。 強化:患者は、その治療はメンのかかます。 -BCV *化学療法:-6日目から-4日目治療の2時間表カルムスチンIV; 4をエトポシドIV -4日目時間;ダウンロードシクロホスファミドIVを-2日じ1時間頂。 -BEAM *化学療法:-7日目と-6日目4時間施カルムスチンIV; 1をエトポシドIV -5日目から-2日目― 1日2回、シタラビンIVを1日2回、2時間頂。 -1日目メルファラン静注。 -TBI、エトポシド、シクロホスファミド:帰は全身照射(TBI)**を2回鳴ます -8日目から-5日目患者毎日。希望はまた、-4日目エトポシドIVを患者ます。 -2日目1時間よりシクロホスファミドIV。 -注:* 61歳別の患者は、BCVおべあむの方かをますます。 -注:* * TBIは61歳患者の患者使用可能的。幹細胞 移植:移植患者、自家プライマー血幹細胞移植ます 0日目移植。 治試験治療後、治療は3治療者に1治療者がます。 2部屋は6外招、かは登録から来8

全体的なステータス 待、
開始日 2011-11-01
完成日 2021-08-01
一次完成日 2016-02-01
段階 Eunãoestivelá
研究の種類 インターベン
主な結果
測る 時間枠
2年後の無増悪生存期間(PFS) 2年
二次転帰
測る 時間枠
Number of Patients With Grade 3 Through Grade 5 Adverse Events That Are Related to Study Drug Up to 8 months (Assessed at the beginning of each cycle of treatment, at restaging, and at post transplant.)
回答率(完全回答著作部回答) モジュール9
5年全生存(OS) 5年
入学 53
状態
介入

介入タイプ: Biological

介入名: rituximab

説明文: Given IV

介入タイプ:

介入名: ベンダムスチン

説明文: 強力なIV

アームグループラベル: 構成II

介入タイプ:

介入名: シクロホスファミド

説明文: 強力なIV

介入タイプ:

介入名: シタラビン

説明文: 強力なIV

アームグループラベル: アームI

介入タイプ:

介入名: デキサメタゾン

説明文: 卓されたPO

アームグループラベル: アームI

介入タイプ:

介入名: ドキソルビシン

説明文: 強力なIV

アームグループラベル: アームI

介入タイプ:

介入名: ロイコボリンカルシウム

説明文: 卓されたPO

アームグループラベル: アームI

介入タイプ:

介入名: メトトレキサート

説明文: 強力なIV

アームグループラベル: アームI

介入タイプ:

介入名: ビンクリスチン硫酸塩

説明文: 強力なIV

アームグループラベル: アームI

適格性

基準:

病気の病気: -ここの患者は、待に未治療の治療III、IV、未かさばるキャンペーンIIのマントルを極なる患者があります 細胞リンパ腫(MCL) -MCLの診断は、これを病理診断する 組織の組織を文書化する 表現型: -CD19 +適合CD20 + -サイクリンD1 +遺伝細胞遺伝学魚魚(11; 14)乗換えの証拠 -元の診断 世世のため -適合な生検組織、組織を組織するのに十分な組織診断あり。 仁にWHOの組織的サブタイプ -コア生検、実数のコア生検で十分なありがあります、、 針の細胞良い細胞は完了あり -骨髄生生血餅要(馬物非)は、 それができますし、ありの診断である診断の診断 利用比 -ここの病気は、患者にない #48031) -測定いヨーク 未前の28日目目評価測定な病気を評価しますますます -患者は中枢神経系(CNS)の法の臨床的方法を リンパ腫 -評価評価に登録前室K線検査 CNSの否定は否定なな -患者は、病期分類用に片側/帰の骨髄穿刺と生検免評価があります ワン前42日照 -生検を適合します。 マントル細胞リンパ腫の変、これは病期分類の目的に遂行と目標モデルます -提供は、構成の要幹細胞移植の審がます 移植は協同組合であります。 移植 -約は84日回幹細胞移植図を計画します得がますます 代の持ち道の1日目着 -患者はこれ1.5X10 ^ 6 CD34 ^ +細胞/ kgをあります。 幹細胞移植前2回前前 患者の患者: -ズブロッドの評価0-2 -ビリルビン≤通常の自己の3倍(ULN) -環クレアチニン≤2.0倍ULN -アラニンアミノトランスフェスト(ALT)ホルアスパラギン酸アミノトランスフェスト(AST)≤2.5倍ULN -アルカリホスファターゼ≤2.5倍ULN -リンパ腫骨髄腫血小板数≥100,000/ mcL -45歳超のすべての病院は、心超音波検査(ECHO)適合 取前(MUGA)は、登録前42日ここにスキャンします(今の方法も 五線で使用するますは、再ステージングを使用するPなるがあります) -45適応表になりECHO / MUGAを使用する -駆出率が患者の患者(ILLN)患者の患者 む外 -全血球計算盤(LDH)と全血球計算盤(CBCと差 ワン前28日目測定測定がますます -HIV検査での病歴 移植は不適合 -活動 -ここをてて、他の徳の腫瘍腫瘍は選択された:治療に治療された 最細胞がん多扁平上皮がん;その場子宮頸がん;細胞細胞がん 患者が今完全解解しているI期卓II期のがん。 患者が5患者無病で他の患者 -中中授乳中の授乳授乳 -生殖能力のある女性同意は、同意あります。 避妊避妊法を使用する のコード: -病気の病気を参照してください

性別:

すべて

最低年齢:

18年

最大年齢:

65年

健康なボランティア:

番号

全体的な公式
苗字 役割 所属
Steven H. Bernstein, MD Principal Investigator James P. Wilmot Cancer Center
ロケーション
施設:
City of Hope Comprehensive Cancer Center | Duarte, California, 91010-3000, United States
Aurora Presbyterian Hospital | Aurora, Colorado, 80012, United States
Boulder Community Hospital | Boulder, Colorado, 80301-9019, United States
Penrose Cancer Center at Penrose Hospital | Colorado Springs, Colorado, 80933, United States
St. Anthony Central Hospital | Denver, Colorado, 80204, United States
Porter Adventist Hospital | Denver, Colorado, 80210, United States
Presbyterian - St. Luke's Medical Center | Denver, Colorado, 80218, United States
St. Joseph Hospital | Denver, Colorado, 80218, United States
Rose Medical Center | Denver, Colorado, 80220, United States
CCOP - Colorado Cancer Research Program | Denver, Colorado, 80222, United States
Swedish Medical Center | Englewood, Colorado, 80110, United States
North Colorado Medical Center | Greeley, Colorado, 80631, United States
Littleton Adventist Hospital | Littleton, Colorado, 80122, United States
Sky Ridge Medical Center | Lone Tree, Colorado, 80124, United States
Hope Cancer Care Center at Longmont United Hospital | Longmont, Colorado, 80501, United States
McKee Medical Center | Loveland, Colorado, 80539, United States
Parker Adventist Hospital | Parker, Colorado, 80138, United States
St. Mary - Corwin Regional Medical Center | Pueblo, Colorado, 81004, United States
Exempla Lutheran Medical Center | Wheat Ridge, Colorado, 80033, United States
Tunnell Cancer Center at Beebe Medical Center | Lewes, Delaware, 19958, United States
CCOP - Christiana Care Health Services | Newark, Delaware, 19713, United States
Florida Hospital Cancer Institute at Florida Hospital Orlando | Orlando, Florida, 32803-1273, United States
St. Joseph Regional Medical Center | Lewiston, Idaho, 83501, United States
Illinois CancerCare - Bloomington | Bloomington, Illinois, 61701, United States
Graham Hospital | Canton, Illinois, 61520, United States
Illinois CancerCare - Canton | Canton, Illinois, 61520, United States
Illinois CancerCare - Carthage | Carthage, Illinois, 62321, United States
Memorial Hospital | Carthage, Illinois, 62321, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago, Illinois, 60611-3013, United States
Hematology and Oncology Associates | Chicago, Illinois, 60611, United States
Decatur Memorial Hospital Cancer Care Institute | Decatur, Illinois, 62526, United States
Eureka Community Hospital | Eureka, Illinois, 61530, United States
Illinois CancerCare - Eureka | Eureka, Illinois, 61530, United States
Galesburg Clinic, PC | Galesburg, Illinois, 61401, United States
Illinois CancerCare - Galesburg | Galesburg, Illinois, 61401, United States
Illinois CancerCare - Havana | Havana, Illinois, 62644, United States
Mason District Hospital | Havana, Illinois, 62644, United States
Kellogg Cancer Care Center | Highland Park, Illinois, 60035, United States
Provena St. Mary's Regional Cancer Center - Kankakee | Kankakee, Illinois, 60901, United States
Illinois CancerCare - Kewanee Clinic | Kewanee, Illinois, 61443, United States
North Shore Oncology and Hematology Associates, Limited - Libertyville | Libertyville, Illinois, 60048, United States
Illinois CancerCare - Macomb | Macomb, Illinois, 61455, United States
McDonough District Hospital | Macomb, Illinois, 61455, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood, Illinois, 60153, United States
Illinois CancerCare - Monmouth | Monmouth, Illinois, 61462, United States
Cancer Care and Hematology Specialists of Chicagoland - Niles | Niles, Illinois, 60714, United States
BroMenn Regional Medical Center | Normal, Illinois, 61761, United States
Community Cancer Center | Normal, Illinois, 61761, United States
Illinois CancerCare - Community Cancer Center | Normal, Illinois, 61761, United States
Community Hospital of Ottawa | Ottawa, Illinois, 61350, United States
Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa, Illinois, 61350, United States
Cancer Treatment Center at Pekin Hospital | Pekin, Illinois, 61554, United States
Illinois CancerCare - Pekin | Pekin, Illinois, 61603, United States
Proctor Hospital | Peoria, Illinois, 61614, United States
CCOP - Illinois Oncology Research Association | Peoria, Illinois, 61615, United States
Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria, Illinois, 61615, United States
Methodist Medical Center of Illinois | Peoria, Illinois, 61636, United States
Illinois CancerCare - Peru | Peru, Illinois, 61354, United States
Illinois Valley Community Hospital | Peru, Illinois, 61354, United States
Illinois CancerCare - Princeton | Princeton, Illinois, 61356, United States
Perry Memorial Hospital | Princeton, Illinois, 61356, United States
Hematology Oncology Associates - Skokie | Skokie, Illinois, 60076, United States
Illinois CancerCare - Spring Valley | Spring Valley, Illinois, 61362, United States
Regional Cancer Center at Memorial Medical Center | Springfield, Illinois, 62781-0001, United States
St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove, Indiana, 46107, United States
Reid Hospital & Health Care Services | Richmond, Indiana, 47374, United States
McFarland Clinic, PC | Ames, Iowa, 50010, United States
Siouxland Hematology-Oncology Associates, LLP | Sioux City, Iowa, 51101, United States
Mercy Medical Center - Sioux City | Sioux City, Iowa, 51102, United States
St. Luke's Regional Medical Center | Sioux City, Iowa, 51104, United States
Cancer Center of Kansas, PA - Chanute | Chanute, Kansas, 66720, United States
Cancer Center of Kansas, PA - Dodge City | Dodge City, Kansas, 67801, United States
Cancer Center of Kansas, PA - El Dorado | El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott | Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas-Independence | Independence, Kansas, 67301, United States
Cancer Center of Kansas, PA - Kingman | Kingman, Kansas, 67068, United States
Lawrence Memorial Hospital | Lawrence, Kansas, 66044, United States
Cancer Center of Kansas, PA - Liberal | Liberal, Kansas, 67901, United States
Cancer Center of Kansas, PA - McPherson | McPherson, Kansas, 67460, United States
Cancer Center of Kansas, PA - Newton | Newton, Kansas, 67114, United States
Cancer Center of Kansas, PA - Parsons | Parsons, Kansas, 67357, United States
Cancer Center of Kansas, PA - Pratt | Pratt, Kansas, 67124, United States
Cancer Center of Kansas, PA - Salina | Salina, Kansas, 67401, United States
Cancer Center of Kansas, PA - Wellington | Wellington, Kansas, 67152, United States
Associates in Womens Health, PA - North Review | Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Medical Arts Tower | Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Wichita | Wichita, Kansas, 67214, United States
CCOP - Wichita | Wichita, Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita, Kansas, 67214, United States
Cancer Center of Kansas, PA - Winfield | Winfield, Kansas, 67156, United States
Lucille P. Markey Cancer Center at University of Kentucky | Lexington, Kentucky, 40536-0093, United States
Union Hospital of Cecil County | Elkton, Maryland, 21921, United States
Hickman Cancer Center at Bixby Medical Center | Adrian, Michigan, 49221, United States
Barbara Ann Karmanos Cancer Institute | Detroit, Michigan, 48201-1379, United States
Mercy Memorial Hospital - Monroe | Monroe, Michigan, 48162, United States
Fairview Ridges Hospital | Burnsville, Minnesota, 55337, United States
Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids, Minnesota, 55433, United States
Fairview Southdale Hospital | Edina, Minnesota, 55435, United States
Mercy and Unity Cancer Center at Unity Hospital | Fridley, Minnesota, 55432, United States
Hutchinson Area Health Care | Hutchinson, Minnesota, 55350, United States
HealthEast Cancer Care at St. John's Hospital | Maplewood, Minnesota, 55109, United States
Minnesota Oncology - Maplewood | Maplewood, Minnesota, 55109, United States
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis, Minnesota, 55407, United States
Hennepin County Medical Center - Minneapolis | Minneapolis, Minnesota, 55415, United States
New Ulm Medical Center | New Ulm, Minnesota, 56073, United States
Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale, Minnesota, 55422-2900, United States
CCOP - Metro-Minnesota | Saint Louis Park, Minnesota, 55416, United States
Park Nicollet Cancer Center | Saint Louis Park, Minnesota, 55416, United States
Regions Hospital Cancer Care Center | Saint Paul, Minnesota, 55101, United States
United Hospital | Saint Paul, Minnesota, 55102, United States
St. Francis Cancer Center at St. Francis Medical Center | Shakopee, Minnesota, 55379, United States
Lakeview Hospital | Stillwater, Minnesota, 55082, United States
Ridgeview Medical Center | Waconia, Minnesota, 55387, United States
Willmar Cancer Center at Rice Memorial Hospital | Willmar, Minnesota, 56201, United States
Minnesota Oncology - Woodbury | Woodbury, Minnesota, 55125, United States
Saint Louis University Cancer Center | Saint Louis, Missouri, 63110, United States
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | Saint Louis, Missouri, 63110, United States
Cancer Institute of New Jersey at Hamilton | Hamilton, New Jersey, 08690, United States
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | New Brunswick, New Jersey, 08903, United States
Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees, New Jersey, 08043, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester, New York, 14642, United States
SUNY Upstate Medical University Hospital | Syracuse, New York, 13210, United States
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center | Columbus, Ohio, 43210-1240, United States
Grandview Hospital | Dayton, Ohio, 45405, United States
Good Samaritan Hospital | Dayton, Ohio, 45406, United States
David L. Rike Cancer Center at Miami Valley Hospital | Dayton, Ohio, 45409, United States
Samaritan North Cancer Care Center | Dayton, Ohio, 45415, United States
CCOP - Dayton | Dayton, Ohio, 45420, United States
Community Cancer Center | Elyria, Ohio, 44035, United States
Hematology Oncology Center | Elyria, Ohio, 44035, United States
Blanchard Valley Medical Associates | Findlay, Ohio, 45840, United States
Middletown Regional Hospital | Franklin, Ohio, 45005-1066, United States
Wayne Hospital | Greenville, Ohio, 45331, United States
Charles F. Kettering Memorial Hospital | Kettering, Ohio, 45429, United States
Lima Memorial Hospital | Lima, Ohio, 45804, United States
Northwest Ohio Oncology Center | Maumee, Ohio, 43537-1839, United States
St. Charles Mercy Hospital | Oregon, Ohio, 43616, United States
North Coast Cancer Care, Incorporated | Sandusky, Ohio, 44870, United States
Flower Hospital Cancer Center | Sylvania, Ohio, 43560, United States
Mercy Hospital of Tiffin | Tiffin, Ohio, 44883, United States
Toledo Hospital | Toledo, Ohio, 43606, United States
St. Vincent Mercy Medical Center | Toledo, Ohio, 43608, United States
Medical University of Ohio Cancer Center | Toledo, Ohio, 43614, United States
CCOP - Toledo Community Hospital | Toledo, Ohio, 43617, United States
St. Anne Mercy Hospital | Toledo, Ohio, 43623, United States
Toledo Clinic, Incorporated - Main Clinic | Toledo, Ohio, 43623, United States
UVMC Cancer Care Center at Upper Valley Medical Center | Troy, Ohio, 45373-1300, United States
Fulton County Health Center | Wauseon, Ohio, 43567, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia, Ohio, 45385, United States
Clackamas Radiation Oncology Center | Clackamas, Oregon, 97015, United States
Providence Milwaukie Hospital | Milwaukie, Oregon, 97222, United States
Providence Newberg Medical Center | Newberg, Oregon, 97132, United States
Willamette Falls Hospital | Oregon City, Oregon, 97045, United States
Providence Cancer Center at Providence Portland Medical Center | Portland, Oregon, 97213-2967, United States
CCOP - Columbia River Oncology Program | Portland, Oregon, 97225, United States
Providence St. Vincent Medical Center | Portland, Oregon, 97225, United States
Geisinger Cancer Institute at Geisinger Health | Danville, Pennsylvania, 17822-0001, United States
Geisinger Hazleton Cancer Center | Hazleton, Pennsylvania, 18201, United States
Geisinger Medical Group - Scenery Park | State College, Pennsylvania, 16801, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre, Pennsylvania, 18711, United States
Cancer Centers of the Carolinas - Faris Road | Greenville, South Carolina, 29605, United States
Cancer Centers of the Carolinas - Grove Commons | Greenville, South Carolina, 29605, United States
Greenville Hospital Cancer Center | Greenville, South Carolina, 29605, United States
CCOP - Greenville | Greenville, South Carolina, 29615, United States
Cancer Centers of the Carolinas - Greer Medical Oncology | Greer, South Carolina, 29650, United States
Cancer Centers of the Carolinas - Seneca | Seneca, South Carolina, 29672, United States
Cancer Centers of the Carolinas - Spartanburg | Spartanburg, South Carolina, 29307, United States
Baylor University Medical Center - Dallas | Dallas, Texas, 75246, United States
Fredericksburg Oncology, Incorporated | Fredericksburg, Virginia, 22401, United States
Island Hospital Cancer Care Center at Island Hospital | Anacortes, Washington, 98221, United States
Overlake Cancer Center at Overlake Hospital Medical Center | Bellevue, Washington, 98004, United States
St. Joseph Cancer Center | Bellingham, Washington, 98225, United States
Olympic Hematology and Oncology | Bremerton, Washington, 98310, United States
Highline Medical Center Cancer Center | Burien, Washington, 98166, United States
Providence Centralia Hospital | Centralia, Washington, 98531-9027, United States
Providence Regional Cancer Partnership | Everett, Washington, 98201, United States
St. Francis Hospital | Federal Way, Washington, 98003, United States
Swedish Medical Center - Issaquah Campus | Issaquah, Washington, 98029, United States
Columbia Basin Hematology | Kennewick, Washington, 99336, United States
Skagit Valley Hospital Cancer Care Center | Mount Vernon, Washington, 98274, United States
Providence St. Peter Hospital Regional Cancer Center | Olympia, Washington, 98506-5166, United States
Harrison Poulsbo Hematology and Onocology | Poulsbo, Washington, 98370, United States
Good Samaritan Cancer Center | Puyallup, Washington, 98372, United States
Harborview Medical Center | Seattle, Washington, 98104, United States
Minor and James Medical, PLLC | Seattle, Washington, 98104, United States
Fred Hutchinson Cancer Research Center | Seattle, Washington, 98109, United States
Group Health Central Hospital | Seattle, Washington, 98112, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle, Washington, 98122-4307, United States
Polyclinic First Hill | Seattle, Washington, 98122, United States
University Cancer Center at University of Washington Medical Center | Seattle, Washington, 98195, United States
North Puget Oncology at United General Hospital | Sedro-Woolley, Washington, 98284, United States
Cancer Care Northwest - Spokane South | Spokane, Washington, 99202, United States
Evergreen Hematology and Oncology, PS | Spokane, Washington, 99218, United States
Franciscan Cancer Center at St. Joseph Medical Center | Tacoma, Washington, 98405-3004, United States
Allenmore Hospital | Tacoma, Washington, 98405, United States
CCOP - Northwest | Tacoma, Washington, 98405, United States
MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma, Washington, 98405, United States
St. Clare Hospital | Tacoma, Washington, 98499, United States
Southwest Washington Medical Center Cancer Center | Vancouver, Washington, 98664, United States
Northwest Cancer Specialists at Vancouver Cancer Center | Vancouver, Washington, 98684, United States
Wenatchee Valley Medical Center | Wenatchee, Washington, 98801-2028, United States
Mary Babb Randolph Cancer Center at West Virginia University Hospitals | Morgantown, West Virginia, 26506, United States
Gundersen Lutheran Center for Cancer and Blood | La Crosse, Wisconsin, 54601, United States
Medical College of Wisconsin Cancer Center | Milwaukee, Wisconsin, 53226, United States
ロケーション国

United States

確認日

2021-05-01

責任者

タイプ: スポンサー

キーワード
アクセスを拡大しました 番号
腕の数 2
アームグループ

ラベル: Arm I

タイプ: Experimental

説明文: Course 1 and 3: Patients receive induction therapy comprising rituximab IV on day 1; cyclophosphamide IV over 3 hours every 12 hours on days 2-4; doxorubicin hydrochloride IV over 72 hours on days 5-7; vincristine sulfate IV on days 5 and 12; and dexamethasone IV or orally (PO) once daily (QD) on days 2-5 and 12-15. Patients with responsive disease after course 1 proceed to course 2. Course 2 and 4: Patients receive rituximab IV on day 1; methotrexate IV over 2-22 hours on day 2; cytarabine IV over 2 hours every 12 hours on days 3-4; and leucovorin calcium PO or IV on days 3-6. Patients then undergo stem cell collection after completion of course 2. Patients undergo stem cell collection after completion of course 2.

ラベル: アームII

タイプ: 実験的

説明文: コース1〜6:患者は1日目にリツキシマブIVを投与され、1〜2日目に30分かけてベンダムスチン塩酸塩IVを投与されます。治療は、病気の進行や許容できない毒性がない場合、4コースで28日ごとに繰り返されます。 3〜4週間後から、反応性疾患の患者はさらに2コースの治療を受けます。 8週間以内に開始し、患者は1日目に1時間にわたってリツキシマブIVとシクロホスファミドIVを投与されます。その後、患者は約26日後に幹細胞の採取を受けます。

研究デザイン情報

割り当て: ランダム

介入モデル: 宣言

主な目的: 処理

マスキング: なし(ブリッジラベル)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact [email protected]. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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