女性の健康イニシアチブ ストロング アンド ヘルシー スタディ (WHISH)

実験的：身体活動への介入

身体活動介入グループは、有酸素運動、柔軟性、バランス、筋力、座っている時間の短縮など、身体活動に関するガイダンスを受けます。 主なリソースは、国立老化研究所の Go4Life エクササイズおよび身体活動資料です。 資料は、高齢者の身体活動に関する米国の国家ガイドラインに基づいています。

行動：身体活動

PA 介入は、エアロビクス、バランス、筋力、柔軟性のマルチモーダル アクティビティ プログラムで構成されます。 介入には、参加者が 1 日を通してあらゆる形態の PA を増やし、座るなどの座りがちな時間を減らすように促すことが含まれます。 これには、レジャー スポーツ、ガーデニング、エスカレーターの代わりに階段を使用する、友人とゆっくりと散歩する、遠隔操作装置の使用を減らすなどの活動が含まれる場合があります。介入は主にメールで行われ、ウェブサイトのサポートとリソースが利用可能です。

介入なし：通常の活動管理

普段の活動

Cardiovascular Events (Composite Myocardial Infarction, Stroke, Cardiovascular Mortality

WHI centrally adjudicated events and CMS FFS-identified events. CVD defined as (first event since enrollment in WHISH of) MI, stroke, cardiovascular (CV) death.

Physical Function (Physical Function Score From Self-report, RAND-36)

Rand-36 Physical Function Scale. Score 0-100; a higher score indicates a more favorable health state in regards to physical functioning. The single value for this Outcome is based on the average of all collected measurements.

Non-Cardiovascular Disease Mortality

Safety. WHI centrally adjudicated events and CMS FFS-identified events.

Hip Fracture

Safety. WHI centrally adjudicated events and CMS FFS-identified events.

Falls / Year

Safety; self-report

Clinical (Non-hip) Fracture

Safety. Self-report

Peripheral Artery Disease

WHI centrally adjudicated events and CMS FFS-identified events.

Venous Thromboembolic Event

WHI centrally adjudicated events and CMS FFS-identified events.

Coronary Revascularization (Coronary Artery Bypass Graft or Percutaneous Coronary Intervention)

Safety; adjudicated events

Mobility Loss

Self-report of ability to climb one flight of stairs or ability to walk one block. Scored 1, 2 or 3 with 1=limited a lot, 2=limited a little, 3=not limited at all. Either stairs or walk with score of 2 or 3 is defined as being able to be mobile.

Mobility Loss: Defined as Yes if a participant self-reports being limited a lot (score =1) in both climbing one flight of stairs and walking one block.

Mobility loss defined as Yes is reported as an Event.

Short Physical Performance Battery (SPPB)

SPPB collected one time during second funding period for WHISH, within the 4-year trial period, as part of the Women's Health Initiative in-home visit, the Long Life Study 2 during 2022-2024. The Established Populations for the Epidemiologic Studies of the Eldery (EPESE) Short Physical Performance Battery (SPPB) ranges from 0 to 12, with higher scores indicating better physical performance.

Sleep Disturbance

Self-report of sleep patterns such as falling asleep, waking during the night, quality of night's sleep. Score scale: 0 - 20; a higher score indicates greater sleep disturbance. Levine DW, Kaplan RM, Kripke DF, Naughton MJ, Shumaker SA. Factor structure and measurement invariance of the Women's Health Initiative Insomnia Rating Scale. Psycho Assess. 2003 Jun; 15(2):123-36. Data not collected prior to 1/6/2021. The single value for this Outcome is based on the average of all collected measurements.

Depressive Symptoms

Shortened version of the Center for Epidemiological Studies Depression Scale (CES- D). Score (probability) for depression. Score scale: 0 - 1; a higher score indicates a greater likelihood of depression. Burman M, Wells K, Leake B, Landsverk J. Development of a brief screening instrument for detecting depressive disorders. Medical care 1988; 26: 8, 775-789. Data not collected prior to 1/6/2021. The single value for this Outcome is based on the average of all collected measurements.