妇女健康倡议强壮健康研究 (WHISH)

实验性的：身体活动干预

身体活动干预小组将接受有关身体活动的指导，包括有氧运动、灵活性、平衡、力量和减少久坐时间。 主要资源是国家老年研究所 Go4Life 运动和身体活动材料。 这些材料基于美国国家老年人体育活动指南

行为的：体力活动

PA 干预将包括有氧运动、平衡、力量和灵活性的多模式活动计划。 干预将包括鼓励参与者全天增加各种形式的体力活动，并减少久坐时间，例如坐着。 这可能包括休闲运动、园艺、使用楼梯代替自动扶梯、与朋友悠闲散步以及减少使用遥控设备等活动。干预主要通过邮件进行，并提供网站支持和可用资源。

无干预：日常活动控制

平时活动

Cardiovascular Events (Composite Myocardial Infarction, Stroke, Cardiovascular Mortality

WHI centrally adjudicated events and CMS FFS-identified events. CVD defined as (first event since enrollment in WHISH of) MI, stroke, cardiovascular (CV) death.

Physical Function (Physical Function Score From Self-report, RAND-36)

Rand-36 Physical Function Scale. Score 0-100; a higher score indicates a more favorable health state in regards to physical functioning. The single value for this Outcome is based on the average of all collected measurements.

Non-Cardiovascular Disease Mortality

Safety. WHI centrally adjudicated events and CMS FFS-identified events.

Hip Fracture

Safety. WHI centrally adjudicated events and CMS FFS-identified events.

Falls / Year

Safety; self-report

Clinical (Non-hip) Fracture

Safety. Self-report

Peripheral Artery Disease

WHI centrally adjudicated events and CMS FFS-identified events.

Venous Thromboembolic Event

WHI centrally adjudicated events and CMS FFS-identified events.

Coronary Revascularization (Coronary Artery Bypass Graft or Percutaneous Coronary Intervention)

Safety; adjudicated events

Mobility Loss

Self-report of ability to climb one flight of stairs or ability to walk one block. Scored 1, 2 or 3 with 1=limited a lot, 2=limited a little, 3=not limited at all. Either stairs or walk with score of 2 or 3 is defined as being able to be mobile.

Mobility Loss: Defined as Yes if a participant self-reports being limited a lot (score =1) in both climbing one flight of stairs and walking one block.

Mobility loss defined as Yes is reported as an Event.

Short Physical Performance Battery (SPPB)

SPPB collected one time during second funding period for WHISH, within the 4-year trial period, as part of the Women's Health Initiative in-home visit, the Long Life Study 2 during 2022-2024. The Established Populations for the Epidemiologic Studies of the Eldery (EPESE) Short Physical Performance Battery (SPPB) ranges from 0 to 12, with higher scores indicating better physical performance.

Sleep Disturbance

Self-report of sleep patterns such as falling asleep, waking during the night, quality of night's sleep. Score scale: 0 - 20; a higher score indicates greater sleep disturbance. Levine DW, Kaplan RM, Kripke DF, Naughton MJ, Shumaker SA. Factor structure and measurement invariance of the Women's Health Initiative Insomnia Rating Scale. Psycho Assess. 2003 Jun; 15(2):123-36. Data not collected prior to 1/6/2021. The single value for this Outcome is based on the average of all collected measurements.

Depressive Symptoms

Shortened version of the Center for Epidemiological Studies Depression Scale (CES- D). Score (probability) for depression. Score scale: 0 - 1; a higher score indicates a greater likelihood of depression. Burman M, Wells K, Leake B, Landsverk J. Development of a brief screening instrument for detecting depressive disorders. Medical care 1988; 26: 8, 775-789. Data not collected prior to 1/6/2021. The single value for this Outcome is based on the average of all collected measurements.