다른 측정 방법론을 사용하여 과일 음료의 혈당 지수 설정
다른 측정 방법론을 사용하여 과일 주스와 스무디의 섭취에 대한 혈당 반응을 조사하십시오.
Glycaemic responses to carbohydrates ingested as fruit sugars may vary depending on factors inherent to the fruit and the type of sugar. The aim of this project is to investigate the glycaemic responses to a range of commercially available fruit drinks and to establish the glycaemic index for each product relative to a glucose reference. Differences in recorded responses could also be influenced by the sample type (capillary blood vs interstitial fluid) and participant characteristics. Participants will ingest 8 test drinks including 5 different fruit drinks (OJ, AJ, S&B, ENERGISE, BLUE), each matched for carbohydrate to the glucose reference (CONTROL) which will be sampled two times, an additional sample of one of the smoothies (S&B) will also be replicated. Fingerstick capillary blood sampling alongside dual sited continuous glucose monitors (CGM) will measure glucose and lactate concentrations, subjective appetite sensations will also be recorded. The tests will follow best practice guidelines for glycaemic index testing. These data will provide insight into how differing formulations can alter the glycaemic responses to fruit drinks, and whether sampling technique can affect the interpretations of measurement.
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
연구 유형
연구 유형
등록 (실제)
등록
단계
단계
- 해당 없음
연락처 및 위치
연구 장소
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Bath, 영국, BA2 7AY
- Department for Health, University of Bath
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참여기준
자격 기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Age: 18-65 years
- Body mass index 18-30 kg/m2
Exclusion Criteria:
- diagnosis of any form of diabetes
- intolerances or allergies to any of the study procedures (e.g. fructose/inulin intolerance)
- Fructose malabsorption
- Inborn errors of fructose metabolism (e.g. fructokinase deficiency, aldolase B deficiency, fructose-1,6-bisphosphatase deficiency)
- pregnant or lactating
- any condition that could introduce bias to the study (e.g. diagnoses of lipid disorders, including cardiovascular disease, or therapies that alter lipid or glucose metabolism, such as statins or niacin).
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 기초 과학
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 없음(오픈 라벨)
팔의 수
무기와 개입
참가자 그룹 / 팔참가자 그룹 / 팔 |
개입 / 치료개입 / 치료 |
|---|---|
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활성 비교기: CONTROL
50 g glucose (55 g dextrose powder accounting for hydration) plus 641 mL water |
Commercially available fruit drinks or smoothies |
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활성 비교기: REPLICATE CONTROL
50 g glucose (55 g dextrose powder accounting for hydration) plus 641 mL water |
Commercially available fruit drinks or smoothies |
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실험적: S&B
417 mL of commercially available "Strawberries & Bananas" fruit smoothie providing 50 g carbohydrate [strawberries (31%), apples, bananas (22%), white grapes, oranges, blackcurrants]. Plus 224 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
|
실험적: REPLICATE S&B
417 mL of commercially available "Strawberries & Bananas" fruit smoothie providing 50 g carbohydrate [strawberries (31%), apples, bananas (22%), white grapes, oranges, blackcurrants]. Plus 224 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
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실험적: OJ
641 mL of commercially available "Smooth Orange Juice" providing 50 g of carbohydrate [100% oranges] |
Commercially available fruit drinks or smoothies |
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실험적: AJ
455 mL commercially available "Apple Juice" providing 50 g of carbohydrate [apples, ascorbic acid]. Plus 186 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
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실험적: ENERGISE
417 mL of commercially available "Energise Super Smoothie" providing 50 g carbohydrate [apples (50%), red grapes, bananas, strawberries (10%), blackcurrants, sour cherries (3.3%), pressed beetroot, flax seeds (0.56%), guarana infusion (0.01%), vitamins B1, B2, B3, B6, C & E]. Plus 224 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
|
실험적: BLUE
521 mL of commercially available "Bolt from the Blue" juice drink providing 50 g carbohydrate [apple (66%), coconut water (18%), white grapes, white guava (5.2%), passion fruit, lime (0.87%), spirulina extract (0.81%) vitamins B1, B2, B3, B6, C & E]. Plus 120 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Glycaemic indices for 5 test drinks measured using capillary blood samples
기간: 120 minutes
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Glycaemic indices [2-hour incremental area under the glucose curve (mmol/L-1x120 minutes) for each of the 5 test drinks relative to mean value of control conditions (CONTROL, REPLICATE CONTROL), expressed as a percentage] in capillary blood samples |
120 minutes
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2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Glycaemic index of all conditions with capillary blood samples vs CGM
기간: 120 minutes
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The difference in glycaemic index [2-hour incremental area under the glucose curve (mmol/L-1x120 minutes) for 5 test drinks relative to mean control (CONTROL, REPLICATE CONTROL), expressed as a percentage] in capillary blood samples versus continuous glucose monitors. |
120 minutes
|
기타 결과 측정
기타 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Comparisons between conditions in glucose concentration in capillary samples
기간: 120 minutes
|
Comparison of blood glucose concentration 2-hour incremental area under the curve (iAUC) min.mmol/L between test conditions |
120 minutes
|
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Comparisons between conditions in glucose concentration in capillary samples
기간: 120 minutes
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Comparison of postprandial peak concentration mmol/L of blood glucose between test conditions (Cmax) |
120 minutes
|
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Comparisons between conditions in glucose concentration in capillary samples
기간: 120 minutes
|
Comparison of time to peak blood glucose concentration in minutes (Tmax) between test conditions |
120 minutes
|
|
Comparisons between conditions in glucose concentration in capillary samples
기간: 120 minutes
|
Comparison of blood glucose concentration mmol/L at 2 hours between test conditions |
120 minutes
|
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Comparisons between conditions in glucose concentration with CGM
기간: 120 minutes
|
Comparison of glucose concentration 2-hour incremental area under the curve (iAUC) min.mmol/L between test conditions |
120 minutes
|
|
Comparisons between conditions in glucose concentration with CGM
기간: 120 minutes
|
Comparison of postprandial peak concentration mmol/L of glucose between test conditions (Cmax) |
120 minutes
|
|
Comparisons between conditions in glucose concentration with CGM
기간: 120 minutes
|
Comparison of time to peak glucose concentration in minutes (Tmax) between test conditions |
120 minutes
|
|
Comparisons between conditions in glucose concentration with CGM
기간: 120 minutes
|
Comparison of glucose concentration mmol/L at 2 hours between test conditions |
120 minutes
|
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Comparisons between conditions in lactate concentration in capillary samples
기간: 120 minutes
|
Comparison of blood lactate concentration 2-hour incremental area under the curve (iAUC) min.mmol/L between test conditions |
120 minutes
|
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Comparisons between conditions in lactate concentration in capillary samples
기간: 120 minutes
|
Comparison of postprandial peak concentration mmol/L of blood lactate between test conditions (Cmax) |
120 minutes
|
|
Comparisons between conditions in lactate concentration in capillary samples
기간: 120 minutes
|
Comparison of time to peak blood lactate concentration in minutes (Tmax) between test conditions |
120 minutes
|
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Comparisons between conditions in lactate concentration in capillary samples
기간: 120 minutes
|
Comparison of blood lactate concentration mmol/L at 2 hours between test conditions |
120 minutes
|
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Comparisons between conditions of appetite ratings
기간: 120 minutes
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Comparison of subjective appetite sensations assessed with visual analogue scales (2-hour area under the curve min.mmVAS) |
120 minutes
|
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Comparisons between individuals
기간: 120 minutes
|
Comparison of Postprandial lactate concentration min.mmol/L between individuals 2-hour incremental area under curve (iAUC) |
120 minutes
|
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Comparisons between individuals
기간: 120 minutes
|
Comparison of Postprandial glucose concentration min.mmol/L between individuals 2-hour incremental area under curve (iAUC) |
120 minutes
|
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Comparisons between individuals
기간: 120 minutes
|
Comparison of Appetite rating responses min.mmVAS between individuals 2-hour area under curve (AUC) |
120 minutes
|
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Comparisons within individuals
기간: 120 minutes
|
Comparison within individuals of interstitial glucose concentrations measurements from continuous glucose monitors on left and right arms. |
120 minutes
|
공동 작업자 및 조사자
간행물 및 유용한 링크
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
연구 시작
기본 완료 (실제)
기본 완료
연구 완료 (실제)
연구 완료
연구 등록 날짜
최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
처음 게시됨
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
기타 연구 ID 번호
기타 연구 ID 번호
- 7134-9931
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
IPD 계획 설명
De-identified data will be made available open access on the University of Bath Research Data Archive (RDA) at the point of publication in a peer-reviewed journal.
IPD 공유 기간
These will become available at the point of publication permanently
IPD 공유 지원 정보 유형
- 연구_프로토콜
- 수액
- ICF
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