Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral Sclerosis

Inclusion Criteria:

• Patient female or male, more than 18 years,
• Patien with a diagnosis of amyotrophic lateral sclerosis according to the El Escorial criteria of Brooks et al. 1994
• Patient , the beginning of the SLA date less than 12 months,
• Patient not having a familial form of ALS,
• Patient not having cancer, autoimmune disease, liver failure, severe hypertension or untreated, severe conduction disorders or uncontrolled arrhythmia
• Patient not having a chronic psychiatric disease, dementia.
• Patient with normal visual function
• Patients receiving social coverage
• Patient have read, understood and signed an informed consent after information

Exclusion Criteria:

• Patient minor
• Patient with a familial form of ALS,
• Patient associated with severe progressive disease (cancer, autoimmune disease , liver failure )
• Patient (s) with chronic mental illness, dementia ,
• Presence of atypical clinical signs such as cerebellar ataxia , extrapyramidal signs, sensory disorders , autonomic dysfunction .
• Clinical signs of chronic respiratory failure or slow and / or forced less than 70% of the theoretical value or chronic hypercapnia than 45 mmHg vital capacity .
• Patient private freedom following a judicial or administrative decision
• Patient major Trust
• Pateinte pregnant, parturient , lactating
• Patient major in legal protection ( guardianship )
• Pateinte pregnant , parturient , lactating
• Patient hospital without consent
• Patient admitted in a health or social establishment for purposes other than research