Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is characterized clinically by abnormalities of both upper motor neurons (UMN) and lower motor neurons (LMN). The presence of UMN signs is not always easy to establish. The only technique used in routine to assess the corticospinal dysfunctions is based on transcranial magnetic stimulation (TMS). However, this technique is largely dependent on LMN state and is based on artificial motor cortex activation.
The main objective of our study project is to evaluate a new method assessing functional changes in motor system in ALS patients. By using cortico-muscular and cortico-cortical coherences, it could be possible to show modifications in both cortico-muscular relationship and in cortical activity coordination which could be related to clinical state in ALS patients. We notably expect a decrease in cortico-muscular coherence in ALS patients. Furthermore, these analyses could provide new insights in motor system plasticity phenomena. We expect a partial covering of voluntary motor command by cortical areas adjacent to primary motor cortex. Lastly, the hypothesis that an increased proportion of voluntary motor control may be assumed by ipsilateral corticospinal tract could be tested by coherence analyses.
Coherence analysis might be a useful method to detect corticospinal tract dysfunctions. This method has the advantage to be painless and not to use artificial stimulations as it is used in TMS.
研究概览
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Marseille、法国、13354
- Assistance Publique Hopitaux de Marseille
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Patient female or male, more than 18 years,
- Patien with a diagnosis of amyotrophic lateral sclerosis according to the El Escorial criteria of Brooks et al. 1994
- Patient , the beginning of the SLA date less than 12 months,
- Patient not having a familial form of ALS,
- Patient not having cancer, autoimmune disease, liver failure, severe hypertension or untreated, severe conduction disorders or uncontrolled arrhythmia
- Patient not having a chronic psychiatric disease, dementia.
- Patient with normal visual function
- Patients receiving social coverage
- Patient have read, understood and signed an informed consent after information
Exclusion Criteria:
- Patient minor
- Patient with a familial form of ALS,
- Patient associated with severe progressive disease (cancer, autoimmune disease , liver failure )
- Patient (s) with chronic mental illness, dementia ,
- Presence of atypical clinical signs such as cerebellar ataxia , extrapyramidal signs, sensory disorders , autonomic dysfunction .
- Clinical signs of chronic respiratory failure or slow and / or forced less than 70% of the theoretical value or chronic hypercapnia than 45 mmHg vital capacity .
- Patient private freedom following a judicial or administrative decision
- Patient major Trust
- Pateinte pregnant, parturient , lactating
- Patient major in legal protection ( guardianship )
- Pateinte pregnant , parturient , lactating
- Patient hospital without consent
- Patient admitted in a health or social establishment for purposes other than research
学习计划
研究是如何设计的?
设计细节
- 主要用途:诊断
- 分配:非随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的:患者
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实验性的:健康志愿者
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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recording neuronal activities
大体时间:12 months
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simultaneous recording of brain activity using electrodes attached to the scalp and muscle activities of muscles of the hands with electrodes bonded to the skin.
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12 months
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
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identify plasticity phenomena
大体时间:12 months
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identify plasticity phenomena used in the cortex during the disease.
The question is whether a reorganization of cortical networks could preserve, temporarily, the ability of patients to perform muscle contractions which case to determine the nature of the changes induced
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12 months
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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electroencephalograms (EEG)的临床试验
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San Francisco Veterans Affairs Medical Center招聘中
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San Francisco Veterans Affairs Medical Center招聘中
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Children's Hospital of PhiladelphiaMasimo Corporation招聘中
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Baptist Health South FloridaFlorida International University撤销
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UNEEG Medical A/SZealand University Hospital; Cambridge Cognition Ltd完全的
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