An [^11C]T-773 Positron Emission Tomography (PET) Study to Determine Phosphodiesterase10A Occupancy by TAK-063

Inclusion Criteria:

1. Has never previously participated in a positron emission tomography (PET) study (lifetime).
2. In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements.
3. The participant, informed consent form and any required privacy authorization prior to the initiation of any study procedures.
4. Is a healthy adult male, as determined by a physician based upon medical history and physical examination findings at Screening.
5. Is aged 20 to 45 years, inclusive, at the time of informed consent.
6. Weighs at least 50 kg and less than 100 kg and has a body mass index (BMI) between 18 and 32 kg/m^2 inclusive at Screening.
7. A male participant who is nonsterilized and sexually active with a female partner of childbearing potential agrees to use adequate contraception from signing of informed consent throughout the duration of the study and for 12 weeks after last dose.
8. Has clinical laboratory evaluations (including clinical chemistry, hematology and complete urinalysis) within the reference range for the testing laboratory, unless the results are deemed not to be clinically significant (CS) by the investigator or sponsor at screening. Participants must have normal hemoglobin levels.
9. Has a normal magnetic resonance imaging (MRI) scan or findings that are deemed not clinically significant at screening (the MRI scan may be performed on a day after other screening activities have been performed but before dosing).

Exclusion Criteria:

1. Has received any investigational compound within 90 days prior to Screening.
2. Has received TAK-063 in a previous clinical study or as a therapeutic agent.
3. Is an immediate family member, study site employee, or in a dependant relationship with a study site employee who is involved in the conduct of this study (eg, spouse, parent, child, sibling) or may consent under duress.
4. Has uncontrolled, clinically significant neurologic, cardiovascular, pulmonary, hepatic, renal, metabolic, gastrointestinal, urologic, immunologic, endocrine disease, or psychiatric disorder, or other abnormality, which may impact the ability of the participant to participate or potentially confound the study results.
5. Has a known hypersensitivity to any component of the formulation of TAK-063 or [^11C]T-773.
6. Has a positive urine drug result for drugs of abuse or a positive breathalyzer test for alcohol at Screening or Day -1.
7. Has a history of drug abuse (defined as any illicit drug use) or a history of alcohol abuse within 1 year prior to the screening visit or is unwilling to agree to abstain from alcohol until discharge from the Phase 1 unit and drugs throughout the study.
8. Has taken any excluded medication, supplements, or food products listed in the Excluded Medications and Dietary Products table.
9. Intends to donate sperm during the course of the study or within 12 weeks after last dose.
10. Has evidence of current cardiovascular, central nervous system, hepatic, hematopoietic disease, renal dysfunction, metabolic or endocrine dysfunction, serious allergy, asthma hypoxemia, hypertension, seizures, or allergic skin rash. There is any finding in the participant's medical history, physical examination, or safety laboratory tests giving reasonable suspicion of a disease that would contraindicate taking TAK-063 or a similar drug in the same class, or that might interfere with the conduct of the study. This includes, but is not limited to, peptic ulcer disease, seizure disorders, and cardiac arrhythmias.
11. The participant, in the opinion of the investigator, has current or recent (within 6 months) gastrointestinal disease that would be expected to influence the absorption of drugs (ie, a history of malabsorption, esophageal reflux, peptic ulcer disease, erosive esophagitis frequent [more than once per week] occurrence of heartburn, or any surgical intervention [eg, cholecystectomy]).
12. Has a history of cancer, except basal cell carcinoma which has been in remission for at least 5 years prior to Day 1.
13. Has a positive test result for hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCV), human immunodeficiency virus (HIV) antibody/antigen, at Screening.
14. Has used nicotine-containing products (including but not limited to cigarettes, pipes, cigars, chewing tobacco, nicotine patch or nicotine gum) within 28 days prior to Check-In Day -1.
15. Has poor peripheral arterial/venous access or recent arm or wrist trauma.
16. Has donated or lost 450 mL or more of his blood volume (including plasmapheresis), or had a transfusion of any blood product within 3 months prior to Day 1.
17. Has a Screening or Check-in (Day -1) abnormal (clinically significant) electrocardiogram (ECG).
18. Has a supine blood pressure outside the ranges of 90 to 140 mm Hg for systolic and 50 to 90 mm Hg for diastolic, if out of range may be repeated once for eligibility determination within a maximum of 5 minutes, at the Screening Visit or Check-in (Day -1).
19. Has a resting heart rate outside the range 45 to 90 beats per minute (bpm), if out of range may be repeated once for eligibility determination within a maximum of 5 minutes, at the Screening Visit or Check-in (Day -1).
20. Has an increase in pulse of ≥30 beats per minute or an increase in pulse ≥120 beats per minute within 3 minutes of standing at Screening.
21. Has a decrease of ≥20 mm Hg in systolic blood pressure or a decrease of ≥10 mm Hg in diastolic blood pressure within 3 minutes of standing at Screening.
22. Has a QT interval with Fridericia correction method (QTcF) >430 ms or PQ interval outside the range 120 to 220 ms, if out of range may be repeated once for eligibility determination within a maximum of 5 minutes, at the Screening Visit or Check-in (Day -1) Visit.
23. Has abnormal Screening laboratory values that suggest a clinically significant underlying disease or participant with the following lab abnormalities: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) >1.5 the upper limits of normal.
24. Has had administration of radioactive substances or exposure to significant radiation (eg, serial x-ray or computed tomography [CT] scans, barium meal) within the past 12 months prior to Day 1 predose.
25. Has any condition that would prevent an MRI from accurately or safely being performed (eg, claustrophobia, cardiac pacemaker, metallic implants or clips)
26. Has any condition that would prevent the performance of a safe or accurate PET scan.
27. Has any clinically significant MRI finding that in the opinion of the investigator would exclude the participant.
28. Is unwilling to refrain from strenuous exercise from 120 hours before Check-in (Day -1) until discharge from the Phase 1 unit.
29. Has a risk of suicide according to the Investigator's clinical judgment (eg, per Columbia-Suicide Severity Rating Scale (C-SSRS) or has made a suicide attempt in the previous 6 months.
30. Has abnormal international normalized ratio (INR) or activated prothrombin time (aPTT) or other risk of bleeding disorder.