폐 정위 절제 방사선 요법 개선을 위한 타진 환기 호흡 평가 연구

다른: 건강한 지원자에 대한 타진 환기 숨참기(PVB) 기법 시행

건강한 환자는 충격식 환기 숨참기 기술을 시행합니다.

다른: 타격 환기 Breathhold SABR(PVB-SABR)

PVB-SABR 치료에서 PVB 기법을 성공적으로 시행한 폐암 환자 수

다른: 폐암 환자의 PVB-SABR 투여

폐암 환자는 PV 호흡 정지 및 검증 콘 빔 CT 스캔을 실행합니다.

다른: 타격 환기 Breathhold SABR(PVB-SABR)

PVB-SABR 치료에서 PVB 기법을 성공적으로 시행한 폐암 환자 수

The rate of successful Percussive Ventilation (PV) breathhold maneuver in healthy volunteers.

The rate will be measured as the proportion of healthy volunteers who can be successfully execute the PV breathhold for 5 minutes. In the event of a failure, both investigator and patient will be asked to specify the reason for failure for purposes of failure analysis.

The rate of successful administration of Percussive Ventilation Breathhold (PVB) Stereotactic Ablative Radiotherapy (SABR) in lung patients.

The rate will be measured as the proportion of lung cancer patients who successfully complete treatment using the PVB SABR method as defined by 100% of the prescribed SABR dose being delivered using the PVB technique. A failure will be defined as a patient who fails to use the method for any part of the treatment. In the event of a failure, both investigator and patient will be asked to specify the reason for failure for purposes of failure analysis.

Additional time-related endpoints for duration of breathhold with Percussive Ventilation (PV) breathhold intervention for Healthy patients

The rates will be measured as the proportion of healthy volunteers who can be successfully execute the PV breathhold for 10 minutes (Arm 1), as well as the proportion of patients who can execute a PV breathhold for both 5 and 10 minutes (Arm 2).

Exploratory clinical and dosimetric data on PVB and PVB-SABR technique

For Arm 1, during treatment planning, radiation plans will be generated using conventional SABR techniques as well as with PVB technique which will enable collection of exploratory dosimetric data such as tumor volume treated, volume and dose to healthy lung irradiated, dose to nearby normal structures and related measures, as well as the reproducibility of sequential breathholds. For both arms, we will collect optional exploratory noninvasive clinical data during PVB including but not limited to real-time CO2 and SpO2 data (using the SenTec Digital Monitoring System or similar device) and surface anatomy monitoring (using devices such as Kinect camera, vision-RT, or laser surface monitoring system). All of these data will be collected on an optional exploratory basis.