Varenicline Effects In Schizophrenic Smokers

Eksperimentell: varenicline

open label varenicline 2mg/day

Legemiddel: Varenicline

Varenicline 1-2 mg/day

Andre navn:

• Chantix

Self Report of Smoking

Patients self-report of smoking cigarettes. Patients were interviewed weekly about the number of cigarettes smoked. Number of cigarettes smoked in the past week.

CO (Carbon Monoxide) Breathalyzer Level

Carbon Monoxide in breath ,parts per million

Plasma Cotinine

cotinine level in plasma ng/ml.

RBANS Neuropsychological Battery

The scale is Repeatable Battery for the Assessment to Neuropsychological Status (RBANS). This scale measures cognitive function in patients with schizophrenia. RBANS scores for list learning range from 0 to 40. RBANS Index scores for visual-spatial index, language index, and Total score range from 40-160. RBANS Total score is the sum of score of all the individual items ( items 1-12) on the RBANS scale. List Learning scores range from 0 to 40. Visual Spatial Construction index scores range from 0 to 30.. Higher scores on all these measures indicate better performance or better cognitive ability.

Change From Baseline in Psychiatric Symptoms

The Positive and Negative Syndrome Scale (PANSS) was used to measure psychiatric symptoms. Item scores ranged from 1 (Absent) to 6 (Severe) for symptoms on the Positive Scale (total subscale range: 7-42), the Negative Scale (total subscale range: 7-42), and the General Psychopathology Scale (total subscale range:16-96). All three subscales were summed for the PANSS total score (total scale range: 30-180). Higher numbers indicate more psychopathology. Therefore, if scores are reduced at post-baseline ratings, this would indicate lower psychopathology.