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Testing av tilsetning av kreftmedisinen Sonrotoclax til standardbehandlingen Zanubrutinib, for tidligere ubehandlet CLL/SLL

2. november 2026 oppdatert av: Alliance for Clinical Trials in Oncology

Fase III-evaluering av fastvarighetsbehandling med zanubrutinib pluss sonrotoclax-basert terapi sammenlignet med kontinuerlig zanubrutinib hos tidligere ubehandlede eldre pasienter med kronisk lymfatisk leukemi/liten lymfocytisk lymfom (CLL/SLL)

This phase III trial compares the effect of adding sonrotoclax to zanubrutinib versus zanubrutinib alone for the treatment of patients with untreated chronic lymphoblastic leukemia (CLL)/small lymphocytic lymphoma (SLL). Sonrotoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib is in a class of medications called kinase inhibitors. It blocks a protein called BTK, which is present on B-cell (a type of white blood cells) cancers such as mantel cell lymphoma at abnormal levels. This may help keep cancer cells from growing and spreading. Giving sonrotoclax and zanubrutinib may be more effective than zanubrutinib alone for the treatment of untreated CLL/SLL.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

PRIMARY OBJECTIVES:

I. To compare the progression free survival (PFS) between minimal residual disease (MRD)-guided zanubrutinib sonrotoclax therapy to continuous zanubrutinib as control.

II. To determine the PFS comparing fixed duration zanubrutinib sonrotoclax therapy to continuous zanubrutinib as control.

SECONDARY OBJECTIVES:

I. To compare the PFS between the patients with MRD-detectable disease treated with fixed duration zanubrutinib sonrotoclax to the PFS of the patients with MRD detectable disease who receive one additional year of combination therapy.

II. To determine the overall survival of all arms of the study. III. To determine the frequency of patients with MRD-detectable disease who convert to undetectable MRD, and at what depth and for how long, after receiving an extra year of combination therapy on the MRD-guided zanubrutinib sonrotoclax therapy arm.

IV. To determine and compare the overall response rate (ORR defined as PR, CR, CCR, CRi) and complete remission rate (CR) after 14 cycles of therapy among the three arms.

V. To compare time to the next CLL/SLL therapy among treatment arms. VI. To determine the rates and severity of toxicity in each arm, with a particular focus on adverse events of special interest that include infections, cardiovascular events (arrhythmias, heart failure, hypertension), tumor lysis syndrome, bleeding events, cytopenias, and second malignancies.

VII. To compare patient-reported symptomatic adverse events as assessed by the Patient Reported Outcome-Common Terminology Criteria for Adverse Events (PRO-CTCAE) between arms 1 and 2.

EXPLORATORY OBJECTIVES:

I. To compare the best achieved rate of undetectable MRD (uMRD) between the fixed duration zanubrutinib sonrotoclax arm and the MRD guided zanubrutinib sonrotoclax arm.

II. To compare rates of undetectable MRD measured by the immunoglobulin heavy chain (IGH) sequencing assay ClonoSeq (sensitivity 1 in 10^-6) to undetectable MRD measured by standard six-color flow cytometry (uMRD4), and to compare results from bone marrow to peripheral blood.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM 1: Patients receive zanubrutinib orally (PO) twice daily (BID) on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo restaging starting at cycle 15 day 1. Patients with at least partial remission continue therapy as described above. Patients with progressive disease proceed to follow up. Patients undergo computed tomography (CT) scan, bone marrow aspiration and blood sample collection throughout the study.

ARM 2: Patients receive zanubrutinib PO BID on days 1-28 of each cycle. Starting cycle 4 day 1 patients also receive sonrotoclax PO daily (QD) on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo restaging starting at cycle 15 day 1. Patients with undetectable MRD and a response of PR, partial response with persistent lymphocytosis (PR-L), CR, CCR or CRi stop therapy at cycle 15 day 28 and proceed to follow up. Patients with detectable MRD and an objective response to therapy are re-randomized to arm 2B or arm 2C.

ARM 2B: Patients continue zanubrutinib PO BID sonrotoclax PO QD on days 1-28 of each cycle. Cycles repeat every 28 days for an additonal 12 cycles in the absence of disease progression or unacceptable toxicity.

ARM 2C: Patients discontinue therapy starting at cycle 15 day 28 and proceed to follow up.

Patients undergo CT scan, bone marrow aspiration and blood sample collection throughout the study.

After completion of study treatment, patients are followed up every 3 months for 3 years then every 6 months until 10 years for study registration. Patients with progression or the start of non protocol CLL directed therapy are followed every 6 months for 10 years from registration.

Studietype

Intervensjonell

Registrering (Antatt)

466

Fase

  • Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studiesteder

  • Forente stater
    • Alabama
      • Birmingham, Alabama, Forente stater, 35233
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        • University of Alabama at Birmingham Cancer Center
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    • California
      • Anaheim, California, Forente stater, 92806
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        • Kaiser Permanente-Anaheim
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          • Ashraf R. Aziz
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      • Baldwin Park, California, Forente stater, 91706
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        • Kaiser Permanente-Baldwin Park
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          • Ashraf R. Aziz
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      • Bellflower, California, Forente stater, 90706
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        • Kaiser Permanente-Bellflower
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          • Ashraf R. Aziz
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      • Dublin, California, Forente stater, 94568
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        • Kaiser Permanente Dublin
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          • Faisal N. Cheema
      • Fontana, California, Forente stater, 92335
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        • Kaiser Permanente-Fontana
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          • Ashraf R. Aziz
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      • Fremont, California, Forente stater, 94538
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        • Kaiser Permanente-Fremont
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      • Fresno, California, Forente stater, 93720
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        • Kaiser Permanente Fresno Orchard Plaza
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          • Telefonnummer: 833-574-2273
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          • Faisal N. Cheema
      • Harbor City, California, Forente stater, 90710
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        • Kaiser Permanente South Bay
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          • Ashraf R. Aziz
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      • Irvine, California, Forente stater, 92618
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        • Kaiser Permanente-Irvine
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      • Los Angeles, California, Forente stater, 90048
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        • Cedars-Sinai Medical Center
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      • Los Angeles, California, Forente stater, 90027
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        • Kaiser Permanente Los Angeles Medical Center
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          • Ashraf R. Aziz
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      • Los Angeles, California, Forente stater, 90034
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        • Kaiser Permanente West Los Angeles
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      • Modesto, California, Forente stater, 95356
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        • Kaiser Permanente- Modesto MOB II
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          • Faisal N. Cheema
      • Oakland, California, Forente stater, 94611
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      • Ontario, California, Forente stater, 91761
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        • Kaiser Permanente-Ontario
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          • Ashraf R. Aziz
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      • Panorama City, California, Forente stater, 91402
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      • Riverside, California, Forente stater, 92505
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      • Roseville, California, Forente stater, 95661
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      • Sacramento, California, Forente stater, 95814
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      • Sacramento, California, Forente stater, 95823
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      • San Diego, California, Forente stater, 92120
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        • Kaiser Permanente-San Diego Zion
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      • San Francisco, California, Forente stater, 94115
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        • Kaiser Permanente-San Francisco
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      • San Jose, California, Forente stater, 95119
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        • Kaiser Permanente-Santa Teresa-San Jose
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        • Hovedetterforsker:
          • Faisal N. Cheema
      • San Leandro, California, Forente stater, 94577
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        • Kaiser Permanente San Leandro
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          • Faisal N. Cheema
      • San Marcos, California, Forente stater, 92078
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        • Kaiser Permanente-San Marcos
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          • Ashraf R. Aziz
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      • San Rafael, California, Forente stater, 94903
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        • Kaiser San Rafael-Gallinas
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          • Faisal N. Cheema
      • Santa Clara, California, Forente stater, 95051
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        • Kaiser Permanente Medical Center - Santa Clara
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      • Santa Rosa, California, Forente stater, 95403
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        • Kaiser Permanente-Santa Rosa
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      • South San Francisco, California, Forente stater, 94080
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        • Kaiser Permanente-South San Francisco
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          • Faisal N. Cheema
      • Vallejo, California, Forente stater, 94589
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        • Kaiser Permanente-Vallejo
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          • Site Public Contact
          • Telefonnummer: 877-642-4691
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        • Hovedetterforsker:
          • Faisal N. Cheema
      • Walnut Creek, California, Forente stater, 94596
        • Rekruttering
        • Kaiser Permanente-Walnut Creek
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          • Site Public Contact
          • Telefonnummer: 877-642-4691
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        • Hovedetterforsker:
          • Faisal N. Cheema
      • Woodland Hills, California, Forente stater, 91367
        • Rekruttering
        • Kaiser Permanente-Woodland Hills
        • Hovedetterforsker:
          • Ashraf R. Aziz
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    • Colorado
      • Colorado Springs, Colorado, Forente stater, 80909
        • Rekruttering
        • UCHealth Memorial Hospital Central
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 719-365-2406
        • Hovedetterforsker:
          • Shin Yin Lee
      • Colorado Springs, Colorado, Forente stater, 80920
        • Rekruttering
        • Memorial Hospital North
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 719-364-6700
        • Hovedetterforsker:
          • Shin Yin Lee
      • Denver, Colorado, Forente stater, 80205
        • Rekruttering
        • Kaiser Permanente-Franklin
        • Hovedetterforsker:
          • Matthew J. Eadens
        • Ta kontakt med:
      • Grand Junction, Colorado, Forente stater, 81505
        • Rekruttering
        • Grand Valley Oncology
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        • Hovedetterforsker:
          • Jonathan D. King
      • Lafayette, Colorado, Forente stater, 80026
        • Rekruttering
        • Kaiser Permanente-Rock Creek
        • Hovedetterforsker:
          • Matthew J. Eadens
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      • Lone Tree, Colorado, Forente stater, 80124
        • Rekruttering
        • Kaiser Permanente-Lone Tree
        • Hovedetterforsker:
          • Matthew J. Eadens
        • Ta kontakt med:
    • Delaware
      • Newark, Delaware, Forente stater, 19713
        • Rekruttering
        • Helen F Graham Cancer Center
        • Hovedetterforsker:
          • Gregory A. Masters
        • Ta kontakt med:
      • Newark, Delaware, Forente stater, 19713
        • Rekruttering
        • Medical Oncology Hematology Consultants PA
        • Hovedetterforsker:
          • Gregory A. Masters
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    • Florida
      • Coral Gables, Florida, Forente stater, 33146
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Coral Gables
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          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Hovedetterforsker:
          • Georgios Pongas
      • Coral Springs, Florida, Forente stater, 33065
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Coral Springs
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          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Hovedetterforsker:
          • Georgios Pongas
      • Deerfield Beach, Florida, Forente stater, 33442
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Hovedetterforsker:
          • Georgios Pongas
      • Doral, Florida, Forente stater, 33166
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Doral
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        • Hovedetterforsker:
          • Georgios Pongas
      • Hollywood, Florida, Forente stater, 33021
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Hollywood
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          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Hovedetterforsker:
          • Georgios Pongas
      • Jupiter, Florida, Forente stater, 33458
        • Rekruttering
        • Jupiter Medical Center
        • Hovedetterforsker:
          • Ryan H. Devine
        • Ta kontakt med:
      • Lakeland, Florida, Forente stater, 33805
        • Rekruttering
        • The Watson Clinic
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 863-680-7780
        • Hovedetterforsker:
          • Leonard J. Gitter
      • Miami, Florida, Forente stater, 33136
        • Rekruttering
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
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          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Hovedetterforsker:
          • Georgios Pongas
      • Miami, Florida, Forente stater, 33176
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Kendall
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          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Hovedetterforsker:
          • Georgios Pongas
      • Miami Beach, Florida, Forente stater, 33140
        • Rekruttering
        • Mount Sinai Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Jacqueline C. Barrientos
      • North Miami, Florida, Forente stater, 33181
        • Rekruttering
        • University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
        • Ta kontakt med:
        • Hovedetterforsker:
          • Georgios Pongas
      • Plantation, Florida, Forente stater, 33324
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Plantation
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          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Hovedetterforsker:
          • Georgios Pongas
    • Hawaii
      • Honolulu, Hawaii, Forente stater, 96819
        • Rekruttering
        • Kaiser Permanente Moanalua Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Faisal N. Cheema
    • Idaho
      • Boise, Idaho, Forente stater, 83706
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Boise
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Caldwell, Idaho, Forente stater, 83605
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Caldwell
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Coeur d'Alene, Idaho, Forente stater, 83814
        • Rekruttering
        • Kootenai Health - Coeur d'Alene
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Meridian, Idaho, Forente stater, 83642
        • Rekruttering
        • Idaho Urologic Institute-Meridian
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Nampa, Idaho, Forente stater, 83687
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Nampa
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Post Falls, Idaho, Forente stater, 83854
        • Rekruttering
        • Kootenai Clinic Cancer Services - Post Falls
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Sandpoint, Idaho, Forente stater, 83864
        • Rekruttering
        • Kootenai Clinic Cancer Services - Sandpoint
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
    • Illinois
      • Bloomington, Illinois, Forente stater, 61704
        • Rekruttering
        • Illinois CancerCare-Bloomington
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Canton, Illinois, Forente stater, 61520
        • Rekruttering
        • Illinois CancerCare-Canton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Carthage, Illinois, Forente stater, 62321
        • Rekruttering
        • Illinois CancerCare-Carthage
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Chicago, Illinois, Forente stater, 60611
        • Rekruttering
        • Northwestern University
        • Ta kontakt med:
        • Hovedetterforsker:
          • Shuo Ma
      • Chicago, Illinois, Forente stater, 60612
        • Rekruttering
        • University of Illinois
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 312-355-3046
        • Hovedetterforsker:
          • Carlos Galvez
      • Danville, Illinois, Forente stater, 61832
        • Rekruttering
        • Carle at The Riverfront
        • Hovedetterforsker:
          • Suparna Mantha
        • Ta kontakt med:
      • Decatur, Illinois, Forente stater, 62526
        • Rekruttering
        • Cancer Care Specialists of Illinois - Decatur
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
      • Decatur, Illinois, Forente stater, 62526
        • Rekruttering
        • Decatur Memorial Hospital
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
      • Dixon, Illinois, Forente stater, 61021
        • Rekruttering
        • Illinois CancerCare-Dixon
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 815-285-7800
      • Effingham, Illinois, Forente stater, 62401
        • Rekruttering
        • Carle Physician Group-Effingham
        • Hovedetterforsker:
          • Suparna Mantha
        • Ta kontakt med:
      • Eureka, Illinois, Forente stater, 61530
        • Rekruttering
        • Illinois CancerCare-Eureka
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Galesburg, Illinois, Forente stater, 61401
        • Rekruttering
        • Illinois CancerCare-Galesburg
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Kewanee, Illinois, Forente stater, 61443
        • Rekruttering
        • Illinois CancerCare-Kewanee Clinic
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Macomb, Illinois, Forente stater, 61455
        • Rekruttering
        • Illinois CancerCare-Macomb
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Mattoon, Illinois, Forente stater, 61938
        • Rekruttering
        • Carle Physician Group-Mattoon/Charleston
        • Hovedetterforsker:
          • Suparna Mantha
        • Ta kontakt med:
      • Normal, Illinois, Forente stater, 61761
        • Rekruttering
        • Carle BroMenn Medical Center
        • Hovedetterforsker:
          • Suparna Mantha
        • Ta kontakt med:
      • Normal, Illinois, Forente stater, 61761
        • Rekruttering
        • Carle Cancer Institute Normal
        • Hovedetterforsker:
          • Suparna Mantha
        • Ta kontakt med:
      • O'Fallon, Illinois, Forente stater, 62269
        • Rekruttering
        • Cancer Care Center of O'Fallon
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
      • O'Fallon, Illinois, Forente stater, 62269
        • Rekruttering
        • HSHS Saint Elizabeth's Hospital
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
      • Ottawa, Illinois, Forente stater, 61350
        • Rekruttering
        • Illinois CancerCare-Ottawa Clinic
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Pekin, Illinois, Forente stater, 61554
        • Rekruttering
        • Illinois CancerCare-Pekin
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Peoria, Illinois, Forente stater, 61615
        • Rekruttering
        • Illinois CancerCare-Peoria
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Peru, Illinois, Forente stater, 61354
        • Rekruttering
        • Illinois CancerCare-Peru
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Princeton, Illinois, Forente stater, 61356
        • Rekruttering
        • Illinois CancerCare-Princeton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
      • Rockford, Illinois, Forente stater, 61114
        • Rekruttering
        • UW Health Carbone Cancer Center Rockford
        • Ta kontakt med:
        • Hovedetterforsker:
          • Fahrettin Covut
      • Shiloh, Illinois, Forente stater, 62269
        • Rekruttering
        • Memorial Hospital East
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dilan A. Patel
      • Springfield, Illinois, Forente stater, 62702
        • Rekruttering
        • Southern Illinois University School of Medicine
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 217-545-7929
      • Springfield, Illinois, Forente stater, 62702
        • Rekruttering
        • Springfield Clinic
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 800-444-7541
      • Springfield, Illinois, Forente stater, 62781
        • Rekruttering
        • Springfield Memorial Hospital
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
      • Urbana, Illinois, Forente stater, 61801
        • Rekruttering
        • Carle Cancer Center
        • Hovedetterforsker:
          • Suparna Mantha
        • Ta kontakt med:
      • Washington, Illinois, Forente stater, 61571
        • Rekruttering
        • Illinois CancerCare - Washington
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bryan A. Faller
    • Iowa
      • Ames, Iowa, Forente stater, 50010
        • Rekruttering
        • Mary Greeley Medical Center
        • Hovedetterforsker:
          • Joseph J. Merchant
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Ames, Iowa, Forente stater, 50010
        • Rekruttering
        • McFarland Clinic - Ames
        • Hovedetterforsker:
          • Joseph J. Merchant
        • Ta kontakt med:
      • Ankeny, Iowa, Forente stater, 50023
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Ankeny Clinic
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Carroll, Iowa, Forente stater, 51401
        • Rekruttering
        • Saint Anthony Regional Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Cedar Rapids, Iowa, Forente stater, 52403
        • Rekruttering
        • Mercy Hospital
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 319-365-4673
        • Hovedetterforsker:
          • Deborah W. Wilbur
      • Cedar Rapids, Iowa, Forente stater, 52403
        • Rekruttering
        • Oncology Associates at Mercy Medical Center
        • Hovedetterforsker:
          • Deborah W. Wilbur
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 319-363-2690
      • Clive, Iowa, Forente stater, 50325
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forente stater, 50314
        • Rekruttering
        • Broadlawns Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-282-2200
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forente stater, 50314
        • Rekruttering
        • Mercy Medical Center - Des Moines
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Richard L. Deming
      • Des Moines, Iowa, Forente stater, 50309
        • Rekruttering
        • Iowa Methodist Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-241-6727
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forente stater, 50309
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forente stater, 50314
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Fort Dodge, Iowa, Forente stater, 50501
        • Rekruttering
        • McFarland Clinic - Trinity Cancer Center
        • Hovedetterforsker:
          • Joseph J. Merchant
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Fort Dodge, Iowa, Forente stater, 50501
        • Rekruttering
        • UI Healthcare Mission Cancer and Blood - Fort Dodge
        • Hovedetterforsker:
          • Seema Harichand-Herdt
        • Ta kontakt med:
      • Marshalltown, Iowa, Forente stater, 50158
        • Rekruttering
        • McFarland Clinic - Marshalltown
        • Hovedetterforsker:
          • Joseph J. Merchant
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Pella, Iowa, Forente stater, 50219
        • Rekruttering
        • UI Healthcare Mission Cancer and Blood - Pella
        • Hovedetterforsker:
          • Seema Harichand-Herdt
        • Ta kontakt med:
      • Waukee, Iowa, Forente stater, 50263
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Waukee Clinic
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Seema Harichand-Herdt
    • Kansas
      • Chanute, Kansas, Forente stater, 66720
        • Rekruttering
        • Cancer Center of Kansas - Chanute
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Dodge City, Kansas, Forente stater, 67801
        • Rekruttering
        • Cancer Center of Kansas - Dodge City
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • El Dorado, Kansas, Forente stater, 67042
        • Rekruttering
        • Cancer Center of Kansas - El Dorado
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Hays, Kansas, Forente stater, 67601
        • Rekruttering
        • HaysMed
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 785-623-5774
      • Independence, Kansas, Forente stater, 67301
        • Rekruttering
        • Cancer Center of Kansas-Independence
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Kansas City, Kansas, Forente stater, 66160
        • Rekruttering
        • University of Kansas Cancer Center
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
      • Kingman, Kansas, Forente stater, 67068
        • Rekruttering
        • Cancer Center of Kansas-Kingman
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Lawrence, Kansas, Forente stater, 66044
        • Rekruttering
        • Lawrence Memorial Hospital
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
      • Liberal, Kansas, Forente stater, 67905
        • Rekruttering
        • Cancer Center of Kansas-Liberal
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • McPherson, Kansas, Forente stater, 67460
        • Rekruttering
        • Cancer Center of Kansas - McPherson
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Newton, Kansas, Forente stater, 67114
        • Rekruttering
        • Cancer Center of Kansas - Newton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Olathe, Kansas, Forente stater, 66061
        • Rekruttering
        • The University of Kansas Cancer Center - Olathe
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
      • Overland Park, Kansas, Forente stater, 66210
        • Rekruttering
        • University of Kansas Cancer Center-Overland Park
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
      • Parsons, Kansas, Forente stater, 67357
        • Rekruttering
        • Cancer Center of Kansas - Parsons
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Pratt, Kansas, Forente stater, 67124
        • Rekruttering
        • Cancer Center of Kansas - Pratt
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Salina, Kansas, Forente stater, 67401
        • Rekruttering
        • Cancer Center of Kansas - Salina
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Salina, Kansas, Forente stater, 67401
        • Rekruttering
        • Salina Regional Health Center
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
      • Topeka, Kansas, Forente stater, 66606
        • Rekruttering
        • University of Kansas Health System Saint Francis Campus
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 785-295-8000
      • Wellington, Kansas, Forente stater, 67152
        • Rekruttering
        • Cancer Center of Kansas - Wellington
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Westwood, Kansas, Forente stater, 66205
        • Rekruttering
        • University of Kansas Hospital-Westwood Cancer Center
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
      • Wichita, Kansas, Forente stater, 67208
        • Rekruttering
        • Cancer Center of Kansas-Wichita Medical Arts Tower
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Wichita, Kansas, Forente stater, 67214
        • Rekruttering
        • Ascension Via Christi Hospitals Wichita
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Wichita, Kansas, Forente stater, 67214
        • Rekruttering
        • Cancer Center of Kansas - Wichita
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Winfield, Kansas, Forente stater, 67156
        • Rekruttering
        • Cancer Center of Kansas - Winfield
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
    • Kentucky
      • Louisville, Kentucky, Forente stater, 40202
        • Rekruttering
        • The James Graham Brown Cancer Center at University of Louisville
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 502-562-3429
        • Hovedetterforsker:
          • Hassaan Yasin
      • Louisville, Kentucky, Forente stater, 40245
        • Rekruttering
        • UofL Health Medical Center Northeast
        • Ta kontakt med:
        • Hovedetterforsker:
          • Hassaan Yasin
    • Louisiana
      • Monroe, Louisiana, Forente stater, 71202
        • Rekruttering
        • Ochsner LSU Health Monroe Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Shiva Jashwanth Gaddam
      • Shreveport, Louisiana, Forente stater, 71103
        • Rekruttering
        • LSU Health Sciences Center at Shreveport
        • Ta kontakt med:
        • Hovedetterforsker:
          • Shiva Jashwanth Gaddam
    • Maine
      • Portland, Maine, Forente stater, 04102
        • Rekruttering
        • MaineHealth Maine Medical Center - Portland
        • Ta kontakt med:
        • Hovedetterforsker:
          • Andrew Rogers
      • South Portland, Maine, Forente stater, 04106
        • Rekruttering
        • MaineHealth Cancer Care and IV Therapy - South Portland
        • Ta kontakt med:
        • Hovedetterforsker:
          • Andrew Rogers
    • Massachusetts
      • Boston, Massachusetts, Forente stater, 02215
        • Rekruttering
        • Dana-Farber Cancer Institute
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-442-3324
        • Hovedetterforsker:
          • Jennifer R. Brown
      • Boston, Massachusetts, Forente stater, 02215
        • Rekruttering
        • Beth Israel Deaconess Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 617-667-9925
        • Hovedetterforsker:
          • Jon E. Arnason
    • Michigan
      • Brighton, Michigan, Forente stater, 48114
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Canton, Michigan, Forente stater, 48188
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Chelsea, Michigan, Forente stater, 48118
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Detroit, Michigan, Forente stater, 48201
        • Rekruttering
        • Wayne State University/Karmanos Cancer Institute
        • Hovedetterforsker:
          • Jay Yang
        • Ta kontakt med:
      • Farmington Hills, Michigan, Forente stater, 48334
        • Rekruttering
        • Weisberg Cancer Treatment Center
        • Hovedetterforsker:
          • Jay Yang
        • Ta kontakt med:
      • Lansing, Michigan, Forente stater, 48912
        • Rekruttering
        • University of Michigan Health - Sparrow Lansing
        • Hovedetterforsker:
          • Christopher M. Reynolds
        • Ta kontakt med:
      • Livonia, Michigan, Forente stater, 48154
        • Rekruttering
        • Trinity Health Saint Mary Mercy Livonia Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Pontiac, Michigan, Forente stater, 48341
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Oakland Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Ypsilanti, Michigan, Forente stater, 48197
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
    • Minnesota
      • Bemidji, Minnesota, Forente stater, 56601
      • Brainerd, Minnesota, Forente stater, 56401
        • Rekruttering
        • Essentia Health Saint Joseph's Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bret E. Friday
      • Burnsville, Minnesota, Forente stater, 55337
        • Rekruttering
        • Minnesota Oncology - Burnsville
        • Ta kontakt med:
        • Hovedetterforsker:
          • Yan Ji
      • Coon Rapids, Minnesota, Forente stater, 55433
        • Rekruttering
        • Mercy Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Yan Ji
      • Deer River, Minnesota, Forente stater, 56636
        • Rekruttering
        • Essentia Health - Deer River Clinic
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bret E. Friday
      • Duluth, Minnesota, Forente stater, 55805
        • Rekruttering
        • Essentia Health Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bret E. Friday
      • Edina, Minnesota, Forente stater, 55435
        • Rekruttering
        • Minnesota Oncology - Edina
        • Ta kontakt med:
        • Hovedetterforsker:
          • Yan Ji
      • Hibbing, Minnesota, Forente stater, 55746
        • Rekruttering
        • Essentia Health Hibbing Clinic
        • Hovedetterforsker:
          • Bret E. Friday
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 218-786-3308
      • Minneapolis, Minnesota, Forente stater, 55407
        • Rekruttering
        • Abbott-Northwestern Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Yan Ji
      • Rochester, Minnesota, Forente stater, 55905
        • Rekruttering
        • Mayo Clinic in Rochester
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 855-776-0015
        • Hovedetterforsker:
          • Sameer A. Parikh
      • Saint Louis Park, Minnesota, Forente stater, 55416
        • Rekruttering
        • Park Nicollet Clinic - Saint Louis Park
        • Ta kontakt med:
        • Hovedetterforsker:
          • Yan Ji
      • Saint Paul, Minnesota, Forente stater, 55101
        • Rekruttering
        • Regions Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Yan Ji
      • Saint Paul, Minnesota, Forente stater, 55102
        • Rekruttering
        • United Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Yan Ji
      • Sandstone, Minnesota, Forente stater, 55072
        • Rekruttering
        • Essentia Health Sandstone
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bret E. Friday
      • Virginia, Minnesota, Forente stater, 55792
        • Rekruttering
        • Essentia Health Virginia Clinic
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bret E. Friday
      • Woodbury, Minnesota, Forente stater, 55125
        • Rekruttering
        • Fairview Cancer Center - Woodbury
        • Hovedetterforsker:
          • Yan Ji
        • Ta kontakt med:
    • Mississippi
      • Southhaven, Mississippi, Forente stater, 38671
        • Rekruttering
        • Baptist Memorial Hospital and Cancer Center-Desoto
        • Ta kontakt med:
        • Hovedetterforsker:
          • Muhammad Raza
    • Missouri
      • Cape Girardeau, Missouri, Forente stater, 63703
        • Rekruttering
        • Saint Francis Medical Center
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 573-334-2230
          • E-post: sfmc@sfmc.net
      • City of Saint Peters, Missouri, Forente stater, 63376
        • Rekruttering
        • Siteman Cancer Center at Saint Peters Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dilan A. Patel
      • Creve Coeur, Missouri, Forente stater, 63141
        • Rekruttering
        • Siteman Cancer Center at West County Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dilan A. Patel
      • Farmington, Missouri, Forente stater, 63640
        • Rekruttering
        • Parkland Health Center - Farmington
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • Kansas City, Missouri, Forente stater, 64154
        • Rekruttering
        • University of Kansas Cancer Center - North
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
      • Kansas City, Missouri, Forente stater, 64108
        • Rekruttering
        • University Health Truman Medical Center
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 816-404-4375
      • Kansas City, Missouri, Forente stater, 64116
        • Rekruttering
        • University of Kansas Cancer Center - Briarcliff
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 913-588-3671
      • Lee's Summit, Missouri, Forente stater, 64064
        • Rekruttering
        • University of Kansas Cancer Center - Lee's Summit
        • Hovedetterforsker:
          • Marc S. Hoffmann
        • Ta kontakt med:
      • Sainte Genevieve, Missouri, Forente stater, 63670
        • Rekruttering
        • Sainte Genevieve County Memorial Hospital
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • St Louis, Missouri, Forente stater, 63110
        • Rekruttering
        • Washington University School of Medicine
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dilan A. Patel
      • St Louis, Missouri, Forente stater, 63129
        • Rekruttering
        • Siteman Cancer Center-South County
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dilan A. Patel
      • St Louis, Missouri, Forente stater, 63136
        • Rekruttering
        • Siteman Cancer Center at Christian Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dilan A. Patel
      • St Louis, Missouri, Forente stater, 63131
        • Rekruttering
        • Missouri Baptist Medical Center
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • Sullivan, Missouri, Forente stater, 63080
        • Rekruttering
        • Missouri Baptist Sullivan Hospital
        • Hovedetterforsker:
          • Bryan A. Faller
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
    • Montana
      • Anaconda, Montana, Forente stater, 59711
        • Rekruttering
        • Community Hospital of Anaconda
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Billings, Montana, Forente stater, 59101
        • Rekruttering
        • Billings Clinic Cancer Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Bozeman, Montana, Forente stater, 59715
        • Rekruttering
        • Bozeman Health Deaconess Hospital
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Great Falls, Montana, Forente stater, 59405
        • Rekruttering
        • Benefis Sletten Cancer Institute
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Kalispell, Montana, Forente stater, 59901
        • Rekruttering
        • Logan Health Medical Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Missoula, Montana, Forente stater, 59804
        • Rekruttering
        • Community Medical Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
    • New Jersey
      • Cherry Hill, New Jersey, Forente stater, 08002
        • Rekruttering
        • Jefferson Cherry Hill Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Michael Wysota
      • Jersey City, New Jersey, Forente stater, 07302
        • Rekruttering
        • Jersey City Medical Center
        • Hovedetterforsker:
          • Joanna M. Rhodes
        • Ta kontakt med:
      • Livingston, New Jersey, Forente stater, 07039
        • Rekruttering
        • Cooperman Barnabas Medical Center
        • Hovedetterforsker:
          • Joanna M. Rhodes
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 973-322-5200
      • Long Branch, New Jersey, Forente stater, 07740
        • Rekruttering
        • Monmouth Medical Center
        • Hovedetterforsker:
          • Joanna M. Rhodes
        • Ta kontakt med:
      • New Brunswick, New Jersey, Forente stater, 08903
        • Rekruttering
        • Rutgers Cancer Institute of New Jersey
        • Hovedetterforsker:
          • Joanna M. Rhodes
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 732-235-7356
      • Sewell, New Jersey, Forente stater, 08080
        • Rekruttering
        • Sidney Kimmel Cancer Center Washington Township
        • Ta kontakt med:
        • Hovedetterforsker:
          • Michael Wysota
    • New York
      • Glens Falls, New York, Forente stater, 12801
        • Suspendert
        • Glens Falls Hospital
      • New York, New York, Forente stater, 10029
        • Rekruttering
        • Mount Sinai Hospital
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 212-824-7309
          • E-post: CCTO@mssm.edu
        • Hovedetterforsker:
          • Suchitra Sundaram
      • Rochester, New York, Forente stater, 14642
        • Rekruttering
        • University of Rochester
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 585-275-5830
        • Hovedetterforsker:
          • Paul M. Barr
      • Webster, New York, Forente stater, 14580
    • North Carolina
      • Chapel Hill, North Carolina, Forente stater, 27599
        • Rekruttering
        • UNC Lineberger Comprehensive Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher E. Jensen
      • Durham, North Carolina, Forente stater, 27710
        • Rekruttering
        • Duke University Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 888-275-3853
        • Hovedetterforsker:
          • Danielle M. Brander
      • Hendersonville, North Carolina, Forente stater, 28791
        • Rekruttering
        • Margaret R Pardee Memorial Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • John K. Hill
    • North Dakota
      • Bismarck, North Dakota, Forente stater, 58501
      • Fargo, North Dakota, Forente stater, 58122
      • Fargo, North Dakota, Forente stater, 58103
        • Rekruttering
        • Essentia Health Cancer Center-South University Clinic
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bret E. Friday
      • Fargo, North Dakota, Forente stater, 58122
    • Ohio
      • Akron, Ohio, Forente stater, 44307
        • Rekruttering
        • Cleveland Clinic Akron General
        • Ta kontakt med:
        • Hovedetterforsker:
          • Taylor Brooks
      • Athens, Ohio, Forente stater, 45701
        • Rekruttering
        • OhioHealth O'Bleness Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Avon, Ohio, Forente stater, 44011
        • Rekruttering
        • Avon - Richard E Jacobs Health Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Taylor Brooks
      • Cleveland, Ohio, Forente stater, 44195
        • Rekruttering
        • Cleveland Clinic Foundation
        • Ta kontakt med:
        • Hovedetterforsker:
          • Taylor Brooks
      • Cleveland, Ohio, Forente stater, 44111
        • Rekruttering
        • Cleveland Clinic Cancer Center/Fairview Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Taylor Brooks
      • Columbus, Ohio, Forente stater, 43214
        • Rekruttering
        • Columbus Oncology and Hematology Associates Inc
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Columbus, Ohio, Forente stater, 43214
        • Rekruttering
        • Riverside Methodist Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Columbus, Ohio, Forente stater, 43215
        • Rekruttering
        • Grant Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Columbus, Ohio, Forente stater, 43228
        • Rekruttering
        • Doctors Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Columbus, Ohio, Forente stater, 43210
        • Rekruttering
        • Ohio State University Comprehensive Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Jennifer A. Woyach
      • Delaware, Ohio, Forente stater, 43015
        • Rekruttering
        • Delaware Health Center-Grady Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Delaware, Ohio, Forente stater, 43015
        • Rekruttering
        • Grady Memorial Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Dublin, Ohio, Forente stater, 43016
        • Rekruttering
        • Columbus Oncology and Hematology Associates
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Dublin, Ohio, Forente stater, 43016
        • Rekruttering
        • Dublin Methodist Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Mansfield, Ohio, Forente stater, 44903
        • Rekruttering
        • OhioHealth Mansfield Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Marion, Ohio, Forente stater, 43302
        • Rekruttering
        • OhioHealth Marion General Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Mayfield Heights, Ohio, Forente stater, 44124
        • Rekruttering
        • Hillcrest Hospital Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Taylor Brooks
      • Pickerington, Ohio, Forente stater, 43147
        • Rekruttering
        • OhioHealth Pickerington Methodist Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
      • Westerville, Ohio, Forente stater, 43082
        • Rekruttering
        • OhioHealth Westerville Medical Campus/Westerville Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Basem M. William
    • Oklahoma
      • Oklahoma City, Oklahoma, Forente stater, 73104
        • Rekruttering
        • University of Oklahoma Health Sciences Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Swaroopa PonnamReddy
    • Oregon
      • Baker City, Oregon, Forente stater, 97814
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Baker City
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Newberg, Oregon, Forente stater, 97132
        • Rekruttering
        • Providence Newberg Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Ontario, Oregon, Forente stater, 97914
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Ontario
        • Ta kontakt med:
        • Hovedetterforsker:
          • Christopher M. Reynolds
      • Oregon City, Oregon, Forente stater, 97045
        • Rekruttering
        • Providence Willamette Falls Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Portland, Oregon, Forente stater, 97213
        • Rekruttering
        • Providence Portland Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Portland, Oregon, Forente stater, 97225
        • Rekruttering
        • Providence Saint Vincent Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Portland, Oregon, Forente stater, 97227
        • Rekruttering
        • Kaiser Permanente Northwest
        • Ta kontakt med:
        • Hovedetterforsker:
          • Abdul Hai Mansoor
    • Pennsylvania
      • Danville, Pennsylvania, Forente stater, 17822
        • Rekruttering
        • Geisinger Medical Center
        • Hovedetterforsker:
          • Joseph J. Vadakara
        • Ta kontakt med:
      • Philadelphia, Pennsylvania, Forente stater, 19107
        • Rekruttering
        • Thomas Jefferson University Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Michael Wysota
      • Philadelphia, Pennsylvania, Forente stater, 19114
        • Rekruttering
        • Jefferson Torresdale Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Michael Wysota
      • Wilkes-Barre, Pennsylvania, Forente stater, 18711
        • Rekruttering
        • Geisinger Wyoming Valley/Henry Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Joseph J. Vadakara
    • Rhode Island
      • Providence, Rhode Island, Forente stater, 02903
        • Rekruttering
        • Rhode Island Hospital
        • Hovedetterforsker:
          • Thomas Ollila
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 401-444-1488
    • South Dakota
      • Aberdeen, South Dakota, Forente stater, 57401
        • Rekruttering
        • Avera Cancer Institute-Aberdeen
        • Ta kontakt med:
        • Hovedetterforsker:
          • Shristi Upadhyay Banskota
      • Mitchell, South Dakota, Forente stater, 57301
        • Rekruttering
        • Avera Cancer Institute - Mitchell
        • Ta kontakt med:
        • Hovedetterforsker:
          • Shristi Upadhyay Banskota
      • Pierre, South Dakota, Forente stater, 57501
        • Rekruttering
        • Avera Cancer Institute at Pierre
        • Ta kontakt med:
        • Hovedetterforsker:
          • Shristi Upadhyay Banskota
      • Sioux Falls, South Dakota, Forente stater, 57104
        • Rekruttering
        • Sanford Cancer Center Oncology Clinic
        • Hovedetterforsker:
          • Daniel Almquist
        • Ta kontakt med:
      • Sioux Falls, South Dakota, Forente stater, 57117-5134
      • Sioux Falls, South Dakota, Forente stater, 57105
        • Rekruttering
        • Avera Cancer Institute
        • Ta kontakt med:
        • Hovedetterforsker:
          • Shristi Upadhyay Banskota
      • Yankton, South Dakota, Forente stater, 57078
        • Rekruttering
        • Avera Cancer Institute at Yankton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Shristi Upadhyay Banskota
    • Tennessee
      • Collierville, Tennessee, Forente stater, 38017
        • Rekruttering
        • Baptist Memorial Hospital and Cancer Center-Collierville
        • Ta kontakt med:
        • Hovedetterforsker:
          • Muhammad Raza
      • Memphis, Tennessee, Forente stater, 38120
        • Rekruttering
        • Baptist Memorial Hospital and Cancer Center-Memphis
        • Ta kontakt med:
        • Hovedetterforsker:
          • Muhammad Raza
    • Texas
      • Abilene, Texas, Forente stater, 79601
        • Rekruttering
        • Hendrick Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 325-670-6340
        • Hovedetterforsker:
          • Jose C. Velasco Di Domenico
    • Virginia
      • Richmond, Virginia, Forente stater, 23298
        • Rekruttering
        • VCU Massey Comprehensive Cancer Center
        • Hovedetterforsker:
          • Bharadhwaj Kolipakkam
        • Ta kontakt med:
      • Tappahannock, Virginia, Forente stater, 22560
        • Rekruttering
        • VCU Health Tappahannock Hospital
        • Hovedetterforsker:
          • Bharadhwaj Kolipakkam
        • Ta kontakt med:
    • Washington
      • Edmonds, Washington, Forente stater, 98026
        • Rekruttering
        • Swedish Cancer Institute-Edmonds
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Issaquah, Washington, Forente stater, 98029
        • Suspendert
        • Swedish Cancer Institute-Issaquah
      • Seattle, Washington, Forente stater, 98122
        • Rekruttering
        • Swedish Medical Center-First Hill
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
    • Wisconsin
      • Ashland, Wisconsin, Forente stater, 54806
        • Rekruttering
        • Duluth Clinic Ashland
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bret E. Friday
      • Green Bay, Wisconsin, Forente stater, 54301
        • Rekruttering
        • Saint Vincent Hospital Cancer Center Green Bay
        • Hovedetterforsker:
          • Anthony J. Jaslowski
        • Ta kontakt med:
      • Green Bay, Wisconsin, Forente stater, 54303
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Saint Mary's
        • Hovedetterforsker:
          • Anthony J. Jaslowski
        • Ta kontakt med:
      • La Crosse, Wisconsin, Forente stater, 54601
        • Rekruttering
        • Gundersen Lutheran Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Michael O. Ojelabi
      • Madison, Wisconsin, Forente stater, 53705
        • Rekruttering
        • William S Middleton VA Medical Center
        • Hovedetterforsker:
          • Christopher D. Fletcher
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 17007 608-256-1901
      • Mukwonago, Wisconsin, Forente stater, 53149
        • Rekruttering
        • ProHealth D N Greenwald Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Timothy R. Wassenaar
      • Oconomowoc, Wisconsin, Forente stater, 53066
        • Rekruttering
        • ProHealth Oconomowoc Memorial Hospital
        • Hovedetterforsker:
          • Timothy R. Wassenaar
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 262-928-7878
      • Oconto Falls, Wisconsin, Forente stater, 54154
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Oconto Falls
        • Hovedetterforsker:
          • Anthony J. Jaslowski
        • Ta kontakt med:
      • Sturgeon Bay, Wisconsin, Forente stater, 54235-1495
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
        • Hovedetterforsker:
          • Anthony J. Jaslowski
        • Ta kontakt med:
      • Waukesha, Wisconsin, Forente stater, 53188
        • Rekruttering
        • UW Cancer Center at ProHealth Care
        • Hovedetterforsker:
          • Timothy R. Wassenaar
        • Ta kontakt med:

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

65 år og eldre (Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

  • STEP 0: This bone marrow or peripheral blood submission to Adaptive is mandatory prior to registration/randomization for real-time identification of the clone needed for MRD testing. The bone marrow sample should be from the first aspiration (i.e., first pull). Aspirate needle should be redirected if needed to get first pull bone marrow aspirate. It should be obtained as soon after pre-registration as possible to confirm registration eligibility

  • STEP 0: Patients must be diagnosed with CLL/SLL according to International Workshop on Chronic Lymphocytic Leukemia (IWCLL) 2018 criteria that includes all of the following:

    • ≥ 5 x10^9 /L B lymphocytes (5000/μL) in the peripheral blood (CLL) or a lymph node biopsy demonstrating SLL with the below immunophenotype (SLL)
    • On morphologic review, the leukemic cells must be small mature lymphocytes
    • Immunophenotype of CLL cells (performed locally) must reveal a clonal B-cell population, which coexpress the B cell surface markers of CD19 and CD20, as well as the T-cell antigen CD5. Patients with bright surface immunoglobulin expression or lack of CD23 expression in > 10% of cells must lack t(11;14) translocation by interphase cytogenetics

  • STEP 0: Patients must meet criteria for treatment as defined by IWCLL 2018 guidelines which includes at least one of the following criteria:

    • Evidence of marrow failure as manifested by the development or worsening of anemia or thrombocytopenia (not attributable to autoimmune hemolytic anemia or thrombocytopenia), typically hemoglobin (Hb) < 10 g/dL, platelet count < 100,000/mm^3

    • Massive (> 6 cm below the costal margin), progressive or symptomatic splenomegaly

    • Massive nodes (ie, > 10 cm in longest diameter) or progressive or symptomatic lymphadenopathy

    • Autoimmune anemia and/or thrombocytopenia that is poorly responsive to standard therapy

    • Constitutional symptoms, which include any of the following:

      • Unintentional weight loss of ≥ 10% within the previous 6 months
      • Significant fatigue (ie. Eastern Cooperative Oncology Group [ECOG] performance status [PS] ≥ 2)
      • Fevers >100.5 °F or 38.0°C for 2 weeks or more without evidence of infection
      • Night sweats > 1 month without evidence of infection

  • STEP 0: Patients must not have had prior therapy for CLL (except palliative steroids or treatment of autoimmune complications of CLL with rituximab or steroids)

  • STEP 0: Treatment with rituximab and/or high-dose corticosteroids for autoimmune complications of CLL must be completed prior to enrollment. Palliative steroids must be at a dose not higher than 20 mg/day of prednisone or equivalent corticosteroid at the time of registration

  • STEP 0: Age ≥ 65 years

  • STEP 0: ECOG performance status ≤ 2

  • STEP 0: Patients with known HIV infection on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible for this trial

  • STEP 0: For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated

  • STEP 0: Patients with a history of hepatitis C virus (HCV), infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

  • STEP 0: Patients must not be receiving active systemic anticoagulation with warfarin. Patients must be off warfarin therapy for at least 5 half-lives washout and with normal INR prior to enrollment

  • STEP 0: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients must be class 2B or better.

Patients with acute cardiac events within 6 months prior to registration should be carefully evaluated for their suitability for enrollment

  • STEP 0: No patients with a history of a severe bleeding disorder or a history of hemorrhagic stroke or intracranial hemorrhage
  • STEP 0: No patients with known active progressive central nervous system (CNS) disease
  • STEP 0: No known medical condition causing an inability to swallow oral formulations of agents
  • STEP 1: The adaptive report confirming a measurable and trackable B cell clone
  • STEP 1: Patients may not have had major surgery within 7 days of enrollment, or minor surgery within 5 days of enrollment. Examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration of a joint. The decision about whether a surgery is major or minor can be made at the discretion of the treating physician
  • STEP 1: No patients with ongoing active fungal, bacterial or viral infection requiring systemic therapy except those described in the protocol document
  • STEP 1: Patients must not require more than 20 mg prednisone or equivalent corticosteroid daily
  • STEP 1: Patients must not have uncontrolled active systemic infection requiring intravenous antibiotics
  • STEP 1: Patients must not have continued requirement for therapy with a strong CYP3A4/5 inhibitor or inducer. Any such inhibitor or inducer must have been discontinued at least 14 days or 5 half-lives (whichever is shorter) before the first dose of study drug
  • STEP 1: Absolute neutrophil count (ANC) ≥ 1,000/mm3 unless due to marrow involvement
  • STEP 1: Platelet count ≥ 30,000/mm3
  • STEP 1: Total bilirubin ≤ 1.5 x upper limit of normal (ULN) (unless due to liver involvement, hemolysis or Gilbert's disease)
  • STEP 1: Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase [SGOT])/ alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) ≤ 3.0 x upper limit of normal (ULN) unless due to disease infiltration of the liver
  • STEP 1: Calculated (calc.) creatinine clearance by Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI) ≥ 30 mL/min
  • STEP 1: Urine protein to creatinine ratio < 1 or urine protein ≤ 1+
  • STEP 2: Detectable MRD ≥ 10 residual clonal cells per million nucleated cells in peripheral blood at the C15 restaging evaluation from ClonoSEQ
  • STEP 2: Response of PR, PR-L, CR, CCR or CRi to zanubrutinib sonrotoclax therapy

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Aktiv komparator: Arm 1 (zanubrutinib)

Patients receive zanubrutinib PO BID on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo restaging starting at cycle 15 day 1. Patients with at least partial remission continue therapy as described above. Patients with progressive disease proceed to follow up. Patients undergo CT scan, bone marrow aspiration and blood sample collection throughout the study.
Fremgangsmåte: Biospecimen Collection

Undergo blood sample collection

Fremgangsmåte: Bone Marrow Aspiration

Undergo bone marrow aspiration

Fremgangsmåte: Computed Tomography

Undergo CT scan

Andre navn:
  • CT skann
  • CT-scan
Annen: Survey Administration

Ancillary studies

Legemiddel: Zanubrutinib

Given PO
Eksperimentell: Arm 2 (zanubrutinib and sonrotoclax)

Patients receive zanubrutinib PO BID on days 1-28 of each cycle. Starting cycle 4 day 1 patients also receive sonrotoclax PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo restaging starting at cycle 15 day 1. Patients with undetectable MRD and a response of PR, PR-L, CR, CCR or CRi stop therapy at cycle 15 day 28 and proceed to follow up. Patients with detectable MRD and an objective response to therapy are re-randomized to arm 2B or arm 2C.

ARM 2B: Patients continue zanubrutinib PO BID sonrotoclax PO QD on days 1-28 of each cycle. Cycles repeat every 28 days for an additonal 12 cycles in the absence of disease progression or unacceptable toxicity.

ARM 2C: Patients discontinue therapy starting at cycle 15 day 28 and proceed to follow up.

Patients undergo CT scan, bone marrow aspiration and blood sample collection
Fremgangsmåte: Biospecimen Collection

Undergo blood sample collection

Fremgangsmåte: Bone Marrow Aspiration

Undergo bone marrow aspiration

Fremgangsmåte: Computed Tomography

Undergo CT scan

Andre navn:
  • CT skann
  • CT-scan
Annen: Survey Administration

Ancillary studies

Legemiddel: Zanubrutinib

Given PO

Legemiddel: Sonrotoclax

Given PO

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Progression free survival (PFS)
Tidsramme: From initial randomization date until the earlier of disease progression or death from any cause, up to 10 years

From initial randomization date until the earlier of disease progression or death from any cause. PFS estimates for zanubrutinib plus sonrotoclax therapy to continuous Zanubrutinib.
From initial randomization date until the earlier of disease progression or death from any cause, up to 10 years

Andre resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
PFS for patients with MRD detectable disease treated with fixed duration zanubrutinib sonrotoclax versus patients with MRD detectable disease who receive one additional year of combination therapy
Tidsramme: up to 10 years

Undetectable (u) MRD will be defined as < 10 in 1,000,000 (less than 1 in 10^-5 [uMRD5]) on peripheral blood, and the depth of response below that level, (i.e. down to 10^-6 [uMRD6]), will also be collected. Kaplan-Meier will be used to estimate survival curves, log-rank tests to compare between survival curves, and hazard ration (HRs) and associated 95% CIs will be reported.
up to 10 years
Overall survival
Tidsramme: Up to 10 years

OS will be summarized using Kaplan-Meier methodology, with hazard ratios from a stratified Cox proportional hazards model and log-rank test results provided.
Up to 10 years
Percentage of patients with MRD detectable disease who convert to uMRD after receiving an extra year of combination therapy on the MRD-guided Zanubrutinib sonrotoclax therapy arm
Tidsramme: Up to 10 years

Proportions of number of MRD+ to uMRD conversion by total number of evaluable patients will be estimated with their corresponding 95% CIs.
Up to 10 years
Overall response rate among treatment arms
Tidsramme: Up to 10 years

Overall response rate is defined as the highest response achieved during the first 15 cycles of treatment. A response is defined as a patients achieving PR+.
Up to 10 years
Time to next CLL/SLL therapy
Tidsramme: Up to 10 years

Kaplan-Meier estimates and 95% CIs of TTNT. Time is measured as the time from the end of initial treatment to the initiation of subsequent treatment.
Up to 10 years
Adverse Event Rates and Severity
Tidsramme: Up to 10 years

Frequency and severity of adverse events and tolerability for each embedded treatment regimen will be collected and summarized using descriptive statistics.
Up to 10 years
Patient-reported symptomatic adverse events
Tidsramme: Up to 10 years

As assessed by the Patient Reported Outcome-Common Terminology Criteria for Adverse Events, the frequency and proportion of patients with a maximum baseline-adjusted composite score greater than 0 will be compared between arms using Fisher's exact test. Similarly, the frequency and proportion of patients with a maximum baseline-adjusted composite score greater than or equal to 3 will be compared between arms using Fisher's exact test.
Up to 10 years

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbeidspartnere

National Cancer Institute (NCI)

Etterforskere

  • Studiestol: Jennifer R Brown, MD, Alliance for Clinical Trials in Oncology

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

30. april 2026

Primær fullføring (Antatt)

30. september 2028

Studiet fullført (Antatt)

30. september 2038

Datoer for studieregistrering

Først innsendt

5. januar 2026

Først innsendt som oppfylte QC-kriteriene

5. januar 2026

Først lagt ut (Faktiske)

7. januar 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

3. november 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

2. november 2026

Sist bekreftet

1. november 2026

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • A042302
  • NCI-2025-08923 (Annen identifikator: NCI Clinical Trial Reporting Program)

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

NEI

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

produkt produsert i og eksportert fra USA

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

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