Changes in mRNA Expression Following Exposure to Naproxen (Lesions3)

Inclusion Criteria:

• Healthy adult between the ages of 18 and 75 inclusive
• Written informed consent prior to undergoing any study procedures
• A physical examination which reveals no clinically significant abnormalities
• Female subjects of childbearing potential must be taking an acceptable form of contraceptive

Exclusion Criteria:

• Any mucosal breaks within 2 cm of pyloric channel seen on baseline endoscopy
• Any GDU or >5 gastroduodenal erosions at baseline endoscopy
• CXB, CPG, ASA, or NS-NSAID use within the prior 2 weeks
• Previous gastrointestinal ulcer
• Hypersensitivity or allergy to NSAIDs, ASA, CPG, CXB or other contraindication to taking treatments
• Baseline complaints of abdominal pain, nausea, and/or cramping
• Any acid blocking medication including antacids, H-2 receptor blocker within the prior 2 weeks, or PPI use within the prior 30 days
• Corticosteroids use within the prior 60 days
• Any documented bleeding tendency
• Has taken warfarin within the prior 60 days
• Three or greater alcoholic beverages daily
• History of cerebro-vascular event