Clinical Evaluation of the Effect of Duodenal-Jejunal Bypass on Type 2 Diabetes

Inclusion Criteria:

• Adults age 20-65 years

• Clinical diagnosis of type II diabetes buy on of the following three criteria (American Diabetes Association)

  1. A normal or high C-peptide level (to exclude type 1 diabetes) (>.9ng/ml)
  2. A random plasma glucose of 200mg/dl or more with typical symptom of diabetes
  3. A fasting plasma glucose of 126mg/dl or more on more than one occasion
• BMI 22-34 KG/m2
• Patients on oral hypoglycemic medications or insulin to control T2DM
• Inadequate control of diabetes as defined as HbA1c>7.5
• No contraindication for surgery or General Anesthesia as determined by multidisciplinary surgical team
• Ability to understand and describe the mechanism of action of ricks and benefits of the operation

Exclusion Criteria:

• Patients who meet any of the following exclusion criteria will be exclusion criteria will be excluded from enrollment into the study
• Enrolled in another clinical study which involves and investigational drug
• Diagnosis type 1 diabetes
• Pregnancy (all female patients will have beta HCG) or planned pregnancy within 2 years of entry into the study or unwilling to use reliable contraceptive method
• Previous gastric or esophageal surgery
• Immunosuppressive drugs including corticosteroids
• Coagulopathy (INR>1.5 or platelets<50,000/ul)
• Anemia (Hgb<10.0g/dl)