Tolerability of Switching to Duloxetine for the Management of Diabetic Nerve Pain
2007年8月1日 更新者:Eli Lilly and Company
A Comparison of Strategies for Switching Patients From Amitriptyline to Duloxetine for the Management of Diabetic Peripheral Neuropathic Pain
This study is to compare the tolerability of different methods for switching from another medication to duloxetine for the management of diabetic nerve pain.
The primary objective is to compare the most gradual method with the most abrupt method, to see if they have different tolerability.
研究概览
研究类型
介入性
注册
205
阶段
- 第四阶段
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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Ponce、波多黎各、00716
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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San Juan、波多黎各、00918
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Arizona
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Phoenix、Arizona、美国、85006
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Florida
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Ft. Myers、Florida、美国、33912
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Tallahassee、Florida、美国、32308
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Hawaii
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Honolulu、Hawaii、美国、96813
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Illinois
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Chicago、Illinois、美国、60610
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Springfield、Illinois、美国、62704
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Iowa
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Iowa City、Iowa、美国、52242
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Kansas
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Topeka、Kansas、美国、66606
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Louisiana
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Baton Rouge、Louisiana、美国、70808
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Missouri
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St Louis、Missouri、美国、63141
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St. Peters、Missouri、美国、63376
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North Carolina
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Morehead City、North Carolina、美国、28557
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Ohio
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Dayton、Ohio、美国、45439
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Oklahoma
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Oklahoma City、Oklahoma、美国、73103
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Texas
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Dallas、Texas、美国、75231
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San Antonio、Texas、美国、78229
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Utah
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Ogden、Utah、美国、84403
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West Virginia
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Charleston、West Virginia、美国、25304
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 及以上 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
描述
Inclusion Criteria:
- You must have been diagnosed with Diabetic Peripheral Neuropathic Pain.
- You must have been taking the same dose of amitriptyline once daily at bedtime for at least four (4) weeks.
- You must have stable glycemic control.
- You must be able to visit the doctor's office once a week for ten (10) weeks.
Exclusion Criteria:
- You are in the acute recovery phase following myocardial infarction.
- You have Major Depressive Disorder, an Anxiety Disorder, or some other psychiatric illnesses that the doctor will ask you about.
- You are allergic to amitriptyline or duloxetine.
- You are currently taking an anticonvulsant, cisapride (Propulsid), or if you have taken an opioid for three or more consecutive days during the 14 days prior to Visit 2.
- You have uncontrolled narrow angle glaucoma.
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:双倍的
研究衡量的是什么?
主要结果指标
结果测量 |
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Subscale of the UKU side effect rating scale to be measured during the switch period. The weeks during which the switch occurs are blinded.
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次要结果测量
结果测量 |
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Daily: 24 hr avg pain, worst pain, night pain; NSAID & acetaminophen use.
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Weekly: Leeds Sleep Evaluation Questionnaire, Brief Profile of Mood States, Clinical Global Impression of Severity. Visits 2, 7, 11: Treatment Satisfaction Questionnaire for Medic
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 研究主任:Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon-Fri 9 AM - 5 PM Eastern time UTC/GMT - 5 hours, EST、Eli Lilly and Company
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2005年12月1日
研究完成 (实际的)
2007年4月1日
研究注册日期
首次提交
2005年12月15日
首先提交符合 QC 标准的
2005年12月15日
首次发布 (估计)
2005年12月19日
研究记录更新
最后更新发布 (估计)
2007年8月3日
上次提交的符合 QC 标准的更新
2007年8月1日
最后验证
2007年8月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
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