Biological Factors in Predicting Response to Treatment in Patients With Esophageal Cancer or Rectal Cancer
Study to Analyze the Predictive Role of Factors Implicated in the Signaling Pathway of the EGFR in Response to Treatment With Neoadjuvant Chemoradiotherapy in Patients With Cancer of the Esophagus or Rectum
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This clinical trial is studying how well biological factors work in predicting response to treatment in patients with esophageal cancer or rectal cancer.
研究概览
详细说明
OBJECTIVES:
Primary
- Analyze various biological factors that can be used as markers to predict response to treatment and correlate with the signaling pathway of EGFR.
Secondary
- Establish a tissue bank to store information about the response to treatment and survival.
OUTLINE: Patients undergo endoscopy, 11 biopsies of tumor tissue, and 3 biopsies of healthy mucosa. Blood samples are also collected. Samples are analyzed for the expression of 4 receptors in the EGFR family, polymorphisms at intron 1 of the EGFR gene, and gene mutations in downstream signaling pathways.
After surgery, patients are followed every 3 months.
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
-
-
-
Montpellier、法国、34298
- 招聘中
- Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
-
接触：
- Marc Ychou, MD, PhD
- 电话号码：33-4-6761-3066
- 邮箱：mychou@valdorel.fnclcc.fr
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
DISEASE CHARACTERISTICS:
- Histologically confirmed adenocarcinoma or squamous cell carcinoma of the esophagus or rectum
- Planning to receive neoadjuvant treatment, including radiotherapy or chemoradiotherapy
PATIENT CHARACTERISTICS:
- Not pregnant or nursing
- No blood disorder
- Not deprived of freedom or protected by law
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
学习计划
研究是如何设计的？
设计细节
- 主要用途：诊断
- 分配：非随机化
研究衡量的是什么？
主要结果指标
结果测量 |
|---|
|
Role of predictive factors in the EGFR signaling pathway in response to treatment
|
次要结果测量
结果测量 |
|---|
|
Establishment of a tissue bank
|
合作者和调查者
调查人员
- 学习椅：Marc Ychou, MD, PhD、Institut du Cancer de Montpellier - Val d'Aurelle
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
基因表达分析的临床试验
-
Foundation for Innovative New Diagnostics, SwitzerlandUniversity of Witwatersrand, South Africa; PD Hinduja Hospital and Medical Research Centre,... 和其他合作者完全的
-
Michigan State University招聘中
-
National Institute for Medical Research, TanzaniaUniversity of Kinshasa (UNIKIN), Congo, The Democratic Republic of the ( Prof Vivi Maketa); Research... 和其他合作者尚未招聘
-
University of North Carolina, Chapel HillCenters for Disease Control and Prevention完全的