Mindfulness to Improve Elders' Immune and Health Status
The purpose of the study is to better understand effects of the Mindfulness-Based Stress-Reduction (MBSR) program on the physical and emotional health and well-being of adults ages 65 and older.
The effects MBSR may have on the immune system is investigated, including how these effects relate to factors such as perceived health, psychological well-being, age, personality, and mood.
研究概览
详细说明
This study investigates the effects of Mindfulness-Based Stress Reduction (MBSR) on immune responses to multiple concentrations of keyhole limpet hemocyanin (KLH) in elderly volunteers. The research design thus capitalizes on the antibody response to a novel, benign antigen to which our subjects will be immunologically naïve. The use of a range of antigen concentrations will provide a sensitive indicator for the effects of intervention.
The Aims of the study are the following:
- To examine the effects of Mindfulness Based Stress Reduction (MBSR) on immunological outcomes, perceived health, and psychological well-being in a sample of seniors 65 years of age and older.
- To examine whether treatment effects are moderated by age, personality traits, physical health status, or depression.
- To examine the effects of behavioral, psychological, and physiological mediators of immune outcome.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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New York
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Rochester、New York、美国、14642
- University of Rochester Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Age 65 or older
- English speaking
- If prescribed antidepressant or anxiolytic medications, must have maintained a stable regimen for eight weeks prior to enrolling
Exclusion Criteria:
- receiving immunosuppressive therapy for cancer or other diseases
- major, uncorrected sensory impairments
- cognitive deficits (MMSE <25, or deficits deemed significant enough to interfere)
- history of a psychotic disorder, bipolar disorder, organic brain syndrome, or mental retardation
- alcohol or substance abuse within the previous year
- severe cardiovascular disease
- known allergies to shellfish
学习计划
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
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有源比较器:Mindfulness-Based Stress Reduction
Participation in the Mindfulness-Based Stress Reduction (MBSR) program following the initial assessment period, just prior to the start of the immunological measures.
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标准化的正念减压 (MBSR) 计划是用于增强正念的主要培训工具。
为期八周的 MBSR 计划旨在教导受试者如何开发内在资源以更好地照顾自己。
MBSR 培训包括学习和精炼一系列技能,旨在增加放松和对与身体症状、情绪和思想相关的身体体验和感觉的认识。
特别强调运动、冥想和呼吸。
其他名称:
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无干预:Wait-list control
Wait-list control participants were offered MBSR training after completion of their primary assessments periods.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
IgG Anti-KLH Antibody Response Post-treatment
大体时间:Immediate post-treatment (time 2)
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Immune function--specifically, antibody response to a novel, benign antigen (an antigen to which subjects are immunologically naïve); in this case, keyhole limpet hemocyanin (KLH).
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Immediate post-treatment (time 2)
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Trail Making Test
大体时间:immediate post-treatment (Time 2)
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The Trail Making Test is a commonly used neuropsychological test of visual attention and task-switching.
In two timed tasks, subjects are asked to first connect numbers (Test A), then alternating numbers and letters (Test B), in sequential order as quickly as possible.
Completion times, relating to cognitive processing speed and executive function (respectively), may be utilized individually, and as a difference (B-A) or ratio (B/A) score.
The Trails B/A ratio was used as an index of improvement in executive control throughout the trial, with lower scores indicating better performance.
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immediate post-treatment (Time 2)
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Electroencephalography Measurement
大体时间:post-treatment (time 2)
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Measurement of alpha asymmetry at the F3/4 (frontal) electrode.
Left prefrontal activation has been associated with positive affect, and with higher levels of antibody responses and natural killer cell cytotoxicity.
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post-treatment (time 2)
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合作者和调查者
调查人员
- 首席研究员:Jan A Moynihan, Ph.D、University of Rochester
出版物和有用的链接
一般刊物
- Gallegos AM, Hoerger M, Talbot NL, Moynihan JA, Duberstein PR. Emotional benefits of mindfulness-based stress reduction in older adults: the moderating roles of age and depressive symptom severity. Aging Ment Health. 2013;17(7):823-9. doi: 10.1080/13607863.2013.799118. Epub 2013 May 22.
- Gallegos AM, Hoerger M, Talbot NL, Krasner MS, Knight JM, Moynihan JA, Duberstein PR. Toward identifying the effects of the specific components of Mindfulness-Based Stress Reduction on biologic and emotional outcomes among older adults. J Altern Complement Med. 2013 Oct;19(10):787-92. doi: 10.1089/acm.2012.0028. Epub 2013 Feb 5.
- Moynihan JA, Chapman BP, Klorman R, Krasner MS, Duberstein PR, Brown KW, Talbot NL. Mindfulness-based stress reduction for older adults: effects on executive function, frontal alpha asymmetry and immune function. Neuropsychobiology. 2013;68(1):34-43. doi: 10.1159/000350949. Epub 2013 Jun 15.
- Chapman BP, van Wijngaarden E, Seplaki CL, Talbot N, Duberstein P, Moynihan J. Openness and conscientiousness predict 34-week patterns of Interleukin-6 in older persons. Brain Behav Immun. 2011 May;25(4):667-73. doi: 10.1016/j.bbi.2011.01.003. Epub 2011 Jan 15.
- Gallegos AM, Moynihan J, Pigeon WR. A Secondary Analysis of Sleep Quality Changes in Older Adults From a Randomized Trial of an MBSR Program. J Appl Gerontol. 2018 Nov;37(11):1327-1343. doi: 10.1177/0733464816663553. Epub 2016 Aug 10.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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