年轻女性乳腺癌研究 (HOHO)
2026年1月30日 更新者：Ann H. Partridge, MD, MPH、Dana-Farber Cancer Institute
帮助自己，帮助他人：年轻女性乳腺癌研究
研究人员正在对患有乳腺癌的年轻女性进行纵向队列研究。
研究人员从学术和社区医疗机构中识别出 40 岁及以下新诊断出乳腺癌的女性。
在女性同意这项研究后，她们会填写调查问卷并提供血样，研究人员会在切除乳腺癌肿瘤后收集组织。
女性在诊断后的头 3 年内每 6 个月接受一次调查，之后每年接受一次调查，持续 7 年（诊断后总随访时间至少为 10 年）。
该研究调查了一组新诊断患有乳腺癌的年轻女性的短期和长期疾病和治疗问题、肿瘤生物学和与患者结果的关系，以及基线和随访中的社会心理问题。
研究概览
地位
主动，不招人
条件
详细说明
这是一项针对患有乳腺癌的年轻女性的纵向队列研究。
在 6 年的时间里，研究人员的目标是从学术和社区医疗机构中识别出 1,600 多名 40 岁及以下新诊断出乳腺癌的女性。
预计其中 1,300 名女性将同意参与一项观察性研究。
将利用患者调查、病历审查以及血液和组织收集。
女性将在诊断后的前 3 年内每 6 个月接受一次调查，然后在接下来的 7 年中每年接受一次调查（诊断后的总随访时间为 10 年）。
该研究将调查一组新诊断出乳腺癌的年轻女性（40 岁或以下）在基线和随访中的短期和长期疾病和治疗问题，以及社会心理问题。
研究人员的目的是在诊断和随访中描述年轻女性人群的疾病和社会心理结果（例如，表现和疾病特征、治疗模式和护理质量、短期和长期副作用以及包括生育在内的社会心理问题、性功能和更年期问题）。
研究人员还将收集肿瘤和血液标本以表征肿瘤，并为未来的研究储存，包括对疾病特征、遗传变异性和血液中激素水平的分子评估。
最终，研究人员的目标是开发结果预测因子，并确定可能适合干预的领域。
研究类型
观察性的
注册 (实际的)
1302
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
-
Ontario
-
Toronto、Ontario、加拿大、3M5
- Sunnybrook Health Sciences Centre
-
-
-
-
Colorado
-
Aurora、Colorado、美国、80045
- University of Colorado Cancer Center
-
-
Massachusetts
-
Boston、Massachusetts、美国、02215
- Dana-Farber Cancer Institute
-
Boston、Massachusetts、美国、02215
- Massachusetts General Hospital
-
Boston、Massachusetts、美国、02215
- Beth-Israel Deaconess Medical Center
-
Danvers、Massachusetts、美国、01923
- MGH/North Shore Cancer Center
-
Hyannis、Massachusetts、美国、02601
- Cape Cod Hospital
-
Lowell、Massachusetts、美国、01854
- Lowell General Hospital
-
Milford、Massachusetts、美国、01757
- DF/BWCC at Milford Regional Medical Center
-
Newton、Massachusetts、美国、02462
- Newton-Wellesley Hospital
-
South Weymouth、Massachusetts、美国、02190
- South Shore Hospital
-
-
Minnesota
-
Rochester、Minnesota、美国、55905
- Mayo Clinic
-
-
New Hampshire
-
Londonderry、New Hampshire、美国、03053
- Dana-Farber/New Hampshire Oncology-Hematology
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 40年 (成人)
接受健康志愿者
不
取样方法
非概率样本
研究人群
这项研究包括新诊断出患有乳腺癌的女性。
他们在诊断时必须小于或等于 40 岁。
描述
纳入标准：
- 女性
- 乳腺癌的诊断
- 诊断时年龄在 40 岁或以下
- 获得患者的知情同意
- 能够理解书面和口头英语，达到完成问卷所需的程度
排除标准：
- 无法理解完成问卷所需的书面和口头英语
- 缺乏知情同意
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
|
年轻女性
新诊断出乳腺癌的年轻女性
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
确定一组新诊断出患有乳腺癌的年轻女性（40 岁或以下）
大体时间：10年
|
在疾病和心理社会结果的诊断和随访中描述年轻女性人群的特征（例如，表现和疾病特征，包括评估患有转移性疾病的女性，报告的频率和与基因检测相关的因素，治疗模式和护理质量，短期和长期副作用和社会心理问题，包括生育能力、性功能和更年期问题）。
|
10年
|
|
标本采集
大体时间：10年
|
收集肿瘤和血液标本以表征肿瘤，并为未来的研究储存，包括疾病特征、遗传变异性和血液中激素水平的分子评估。
|
10年
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
确定结果的预测因素
大体时间：10年
|
最终，研究人员的目标是开发结果预测因子，并确定可能适合对患有乳腺癌的年轻女性进行干预的领域。
|
10年
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员：Virginia Borges, MD、University of Colorado, Denver
- 首席研究员：Jeffrey Peppercorn, MD、Massachusetts General Hospital
- 首席研究员：Steven Come, MD, MPH、Beth Israel Deaconess Medical Center
- 首席研究员：Therese Mulvey, MD、Mass General/North-Shore Cancer Center
- 首席研究员：Blair Ardman, MD、Lowell General Hospital
- 首席研究员：Lawrence Blaszkowsky, MD、Newton-Wellesley Hospital
- 首席研究员：Frank G Basile, MD、Cape Cod Hospital
- 首席研究员：Ellen Warner, MD、Sunnybrook Health Sciences Centre
- 首席研究员：Kathryn Ruddy, MD, MPH、Mayo Clinic
- 首席研究员：Katherina Zabicki Calvillo, MD, FACS、South Shore Hospital
- 首席研究员：Jeanna Walsh, MD、Dana-Farber/New Hampshire Oncology-Hematology
- 首席研究员：Natalie Sinclair, MD、DF/BWCC at Milford Regional Medical Center
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Collins LC, Marotti JD, Gelber S, Cole K, Ruddy K, Kereakoglow S, Brachtel EF, Schapira L, Come SE, Winer EP, Partridge AH. Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer. Breast Cancer Res Treat. 2012 Feb;131(3):1061-6. doi: 10.1007/s10549-011-1872-9. Epub 2011 Nov 13.
- Rosenberg SM, Tamimi RM, Gelber S, Ruddy KJ, Kereakoglow S, Borges VF, Come SE, Schapira L, Winer EP, Partridge AH. Body image in recently diagnosed young women with early breast cancer. Psychooncology. 2013 Aug;22(8):1849-55. doi: 10.1002/pon.3221. Epub 2012 Nov 7.
- Rosenberg SM, Tracy MS, Meyer ME, Sepucha K, Gelber S, Hirshfield-Bartek J, Troyan S, Morrow M, Schapira L, Come SE, Winer EP, Partridge AH. Perceptions, knowledge, and satisfaction with contralateral prophylactic mastectomy among young women with breast cancer: a cross-sectional survey. Ann Intern Med. 2013 Sep 17;159(6):373-81. doi: 10.7326/0003-4819-159-6-201309170-00003.
- Ruddy KJ, Gelber S, Tamimi RM, Schapira L, Come SE, Meyer ME, Winer EP, Partridge AH. Breast cancer presentation and diagnostic delays in young women. Cancer. 2014 Jan 1;120(1):20-5. doi: 10.1002/cncr.28287. Epub 2013 Nov 11.
- Ruddy KJ, Gelber SI, Tamimi RM, Ginsburg ES, Schapira L, Come SE, Borges VF, Meyer ME, Partridge AH. Prospective study of fertility concerns and preservation strategies in young women with breast cancer. J Clin Oncol. 2014 Apr 10;32(11):1151-6. doi: 10.1200/JCO.2013.52.8877. Epub 2014 Feb 24.
- Rosenberg SM, Tamimi RM, Gelber S, Ruddy KJ, Bober SL, Kereakoglow S, Borges VF, Come SE, Schapira L, Partridge AH. Treatment-related amenorrhea and sexual functioning in young breast cancer survivors. Cancer. 2014 Aug 1;120(15):2264-71. doi: 10.1002/cncr.28738. Epub 2014 May 28.
- Rosenberg SM, Sepucha K, Ruddy KJ, Tamimi RM, Gelber S, Meyer ME, Schapira L, Come SE, Borges VF, Golshan M, Winer EP, Partridge AH. Local Therapy Decision-Making and Contralateral Prophylactic Mastectomy in Young Women with Early-Stage Breast Cancer. Ann Surg Oncol. 2015 Nov;22(12):3809-15. doi: 10.1245/s10434-015-4572-6. Epub 2015 May 1.
- Borstelmann NA, Rosenberg SM, Ruddy KJ, Tamimi RM, Gelber S, Schapira L, Come S, Borges V, Morgan E, Partridge AH. Partner support and anxiety in young women with breast cancer. Psychooncology. 2015 Dec;24(12):1679-85. doi: 10.1002/pon.3780. Epub 2015 Mar 13.
- Collins LC, Gelber S, Marotti JD, White S, Ruddy K, Brachtel EF, Schapira L, Come SE, Borges VF, Schedin P, Warner E, Wensley T, Tamimi RM, Winer EP, Partridge AH. Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women. Oncologist. 2015 Jul;20(7):713-8. doi: 10.1634/theoncologist.2014-0412. Epub 2015 May 29.
- Walker HE, Rosenberg SM, Stanton AL, Petrie KJ, Partridge AH. Perceptions, Attributions, and Emotions Toward Endocrine Therapy in Young Women with Breast Cancer. J Adolesc Young Adult Oncol. 2016 Mar;5(1):16-23. doi: 10.1089/jayao.2015.0051. Epub 2015 Dec 17.
- Rosenberg SM, Ruddy KJ, Tamimi RM, Gelber S, Schapira L, Come S, Borges VF, Larsen B, Garber JE, Partridge AH. BRCA1 and BRCA2 Mutation Testing in Young Women With Breast Cancer. JAMA Oncol. 2016 Jun 1;2(6):730-6. doi: 10.1001/jamaoncol.2015.5941.
- Goddard ET, Hill RC, Nemkov T, D'Alessandro A, Hansen KC, Maller O, Mongoue-Tchokote S, Mori M, Partridge AH, Borges VF, Schedin P. The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis. Cancer Discov. 2017 Feb;7(2):177-187. doi: 10.1158/2159-8290.CD-16-0822. Epub 2016 Dec 14.
- Olsen SN, Wronski A, Castano Z, Dake B, Malone C, De Raedt T, Enos M, DeRose YS, Zhou W, Guerra S, Loda M, Welm A, Partridge AH, McAllister SS, Kuperwasser C, Cichowski K. Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers. Cancer Discov. 2017 Feb;7(2):202-217. doi: 10.1158/2159-8290.CD-16-0520. Epub 2016 Dec 14.
- Park EM, Gelber S, Rosenberg SM, Seah DSE, Schapira L, Come SE, Partridge AH. Anxiety and Depression in Young Women With Metastatic Breast Cancer: A Cross-Sectional Study. Psychosomatics. 2018 May-Jun;59(3):251-258. doi: 10.1016/j.psym.2018.01.007. Epub 2018 Jan 31.
- von Hippel C, Rosenberg SM, Austin SB, Sprunck-Harrild K, Ruddy KJ, Schapira L, Come S, Borges VF, Partridge AH. Identifying distinct trajectories of change in young breast cancer survivors' sexual functioning. Psychooncology. 2019 May;28(5):1033-1040. doi: 10.1002/pon.5047. Epub 2019 Mar 13.
- Wassermann J, Gelber SI, Rosenberg SM, Ruddy KJ, Tamimi RM, Schapira L, Borges VF, Come SE, Meyer ME, Partridge AH. Nonadherent behaviors among young women on adjuvant endocrine therapy for breast cancer. Cancer. 2019 Sep 15;125(18):3266-3274. doi: 10.1002/cncr.32192. Epub 2019 May 23.
- Rosenberg SM, Vaz-Luis I, Gong J, Rajagopal PS, Ruddy KJ, Tamimi RM, Schapira L, Come S, Borges V, de Moor JS, Partridge AH. Employment trends in young women following a breast cancer diagnosis. Breast Cancer Res Treat. 2019 Aug;177(1):207-214. doi: 10.1007/s10549-019-05293-x. Epub 2019 May 30.
- Lee GE, Rosenberg SM, Mayer EL, Borges V, Meyer ME, Schapira L, Come SE, Partridge AH. Contemporary management of breast cancer during pregnancy and subsequent lactation in a multicenter cohort of young women with breast cancer. Breast J. 2019 Nov;25(6):1104-1110. doi: 10.1111/tbj.13431. Epub 2019 Jul 18.
- Poorvu PD, Gelber SI, Rosenberg SM, Ruddy KJ, Tamimi RM, Collins LC, Peppercorn J, Schapira L, Borges VF, Come SE, Warner E, Jakubowski DM, Russell C, Winer EP, Partridge AH. Prognostic Impact of the 21-Gene Recurrence Score Assay Among Young Women With Node-Negative and Node-Positive ER-Positive/HER2-Negative Breast Cancer. J Clin Oncol. 2020 Mar 1;38(7):725-733. doi: 10.1200/JCO.19.01959. Epub 2019 Dec 6.
- Pak LM, Gaither R, Rosenberg SM, Ruddy KJ, Tamimi RM, Peppercorn J, Schapira L, Borges VF, Come SE, Warner E, Snow C, Collins LC, King TA, Partridge AH. Tumor phenotype and concordance in synchronous bilateral breast cancer in young women. Breast Cancer Res Treat. 2021 Apr;186(3):815-821. doi: 10.1007/s10549-020-06027-0. Epub 2020 Nov 26.
- Parsons HA, Rhoades J, Reed SC, Gydush G, Ram P, Exman P, Xiong K, Lo CC, Li T, Fleharty M, Kirkner GJ, Rotem D, Cohen O, Yu F, Fitarelli-Kiehl M, Leong KW, Hughes ME, Rosenberg SM, Collins LC, Miller KD, Blumenstiel B, Trippa L, Cibulskis C, Neuberg DS, DeFelice M, Freeman SS, Lennon NJ, Wagle N, Ha G, Stover DG, Choudhury AD, Getz G, Winer EP, Meyerson M, Lin NU, Krop I, Love JC, Makrigiorgos GM, Partridge AH, Mayer EL, Golub TR, Adalsteinsson VA. Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer. Clin Cancer Res. 2020 Jun 1;26(11):2556-2564. doi: 10.1158/1078-0432.CCR-19-3005. Epub 2020 Mar 13.
- Vazquez D, Rosenberg S, Gelber S, Ruddy KJ, Morgan E, Recklitis C, Come S, Schapira L, Partridge AH. Posttraumatic stress in breast cancer survivors diagnosed at a young age. Psychooncology. 2020 Aug;29(8):1312-1320. doi: 10.1002/pon.5438. Epub 2020 Jul 9.
- Rosenberg SM, Dominici LS, Gelber S, Poorvu PD, Ruddy KJ, Wong JS, Tamimi RM, Schapira L, Come S, Peppercorn JM, Borges VF, Partridge AH. Association of Breast Cancer Surgery With Quality of Life and Psychosocial Well-being in Young Breast Cancer Survivors. JAMA Surg. 2020 Nov 1;155(11):1035-1042. doi: 10.1001/jamasurg.2020.3325.
- Borstelmann NA, Rosenberg S, Gelber S, Zheng Y, Meyer M, Ruddy KJ, Schapira L, Come S, Borges V, Cadet T, Maramaldi P, Partridge AH. Partners of young breast cancer survivors: a cross-sectional evaluation of psychosocial concerns, coping, and mental health. J Psychosoc Oncol. 2020 Nov-Dec;38(6):670-686. doi: 10.1080/07347332.2020.1823546. Epub 2020 Oct 1.
- Poorvu PD, Gelber SI, Zheng Y, Ruddy KJ, Tamimi RM, Peppercorn J, Schapira L, Borges VF, Come SE, Lambertini M, Rosenberg SM, Partridge AH. Pregnancy after breast cancer: Results from a prospective cohort of young women with breast cancer. Cancer. 2021 Apr 1;127(7):1021-1028. doi: 10.1002/cncr.33342. Epub 2020 Dec 1.
- Lambertini M, Ameye L, Hamy AS, Zingarello A, Poorvu PD, Carrasco E, Grinshpun A, Han S, Rousset-Jablonski C, Ferrari A, Paluch-Shimon S, Cortesi L, Senechal C, Miolo G, Pogoda K, Perez-Fidalgo JA, De Marchis L, Ponzone R, Livraghi L, Estevez-Diz MDP, Villarreal-Garza C, Dieci MV, Clatot F, Berliere M, Graffeo R, Teixeira L, Cordoba O, Sonnenblick A, Luna Pais H, Ignatiadis M, Paesmans M, Partridge AH, Caron O, Saule C, Del Mastro L, Peccatori FA, Azim HA Jr. Pregnancy After Breast Cancer in Patients With Germline BRCA Mutations. J Clin Oncol. 2020 Sep 10;38(26):3012-3023. doi: 10.1200/JCO.19.02399. Epub 2020 Jul 16.
- Sella T, Gelber SI, Poorvu PD, Kim HJ, Dominici L, Guzman-Arocho YD, Collins L, Ruddy KJ, Tamimi RM, Peppercorn JM, Schapira L, Borges VF, Come SE, Warner E, Snow C, Jakubowski DM, Russell CA, Winer EP, Rosenberg SM, Partridge AH. Response to neoadjuvant chemotherapy and the 21-gene Breast Recurrence Score test in young women with estrogen receptor-positive early breast cancer. Breast Cancer Res Treat. 2021 Feb;186(1):157-165. doi: 10.1007/s10549-020-05989-5. Epub 2020 Nov 4.
- Kim HJ, Dominici L, Rosenberg SM, Zheng Y, Pak LM, Poorvu PD, Ruddy KJ, Tamimi R, Schapira L, Come SE, Peppercorn J, Borges VF, Warner E, Vardeh H, Collins LC, Gaither R, King TA, Partridge AH. Surgical Treatment After Neoadjuvant Systemic Therapy in Young Women With Breast Cancer: Results From a Prospective Cohort Study. Ann Surg. 2022 Jul 1;276(1):173-179. doi: 10.1097/SLA.0000000000004296. Epub 2020 Dec 23.
- Sella T, Poorvu PD, Ruddy KJ, Gelber SI, Tamimi RM, Peppercorn JM, Schapira L, Borges VF, Come SE, Partridge AH, Rosenberg SM. Impact of fertility concerns on endocrine therapy decisions in young breast cancer survivors. Cancer. 2021 Aug 15;127(16):2888-2894. doi: 10.1002/cncr.33596. Epub 2021 Apr 22.
- Kuijer A, Dominici LS, Rosenberg SM, Hu J, Gelber S, Di Lascio S, Wong JS, Ruddy KJ, Tamimi RM, Schapira L, Borges VF, Come SE, Sprunck-Harrild K, Partridge AH, King TA. Arm Morbidity After Local Therapy for Young Breast Cancer Patients. Ann Surg Oncol. 2021 Oct;28(11):6071-6082. doi: 10.1245/s10434-021-09947-3. Epub 2021 Apr 21.
- Guzman-Arocho YD, Rosenberg SM, Garber JE, Vardeh H, Poorvu PD, Ruddy KJ, Kirkner G, Snow C, Tamimi RM, Peppercorn J, Schapira L, Borges VF, Come SE, Brachtel EF, Marotti JD, Warner E, Partridge AH, Collins LC. Clinicopathological features and BRCA1 and BRCA2 mutation status in a prospective cohort of young women with breast cancer. Br J Cancer. 2022 Feb;126(2):302-309. doi: 10.1038/s41416-021-01597-2. Epub 2021 Oct 26.
- Lambertini M, Blondeaux E, Bruzzone M, Perachino M, Anderson RA, de Azambuja E, Poorvu PD, Kim HJ, Villarreal-Garza C, Pistilli B, Vaz-Luis I, Saura C, Ruddy KJ, Franzoi MA, Sertoli C, Ceppi M, Azim HA Jr, Amant F, Demeestere I, Del Mastro L, Partridge AH, Pagani O, Peccatori FA. Pregnancy After Breast Cancer: A Systematic Review and Meta-Analysis. J Clin Oncol. 2021 Oct 10;39(29):3293-3305. doi: 10.1200/JCO.21.00535. Epub 2021 Jul 1.
- Poorvu PD, Hu J, Zheng Y, Gelber SI, Ruddy KJ, Tamimi RM, Peppercorn JM, Schapira L, Borges VF, Come SE, Warner E, Lambertini M, Rosenberg SM, Partridge AH. Treatment-related amenorrhea in a modern, prospective cohort study of young women with breast cancer. NPJ Breast Cancer. 2021 Jul 27;7(1):99. doi: 10.1038/s41523-021-00307-8.
- Lambertini M, Ceppi M, Hamy AS, Caron O, Poorvu PD, Carrasco E, Grinshpun A, Punie K, Rousset-Jablonski C, Ferrari A, Paluch-Shimon S, Toss A, Senechal C, Puglisi F, Pogoda K, Perez-Fidalgo JA, De Marchis L, Ponzone R, Livraghi L, Estevez-Diz MDP, Villarreal-Garza C, Dieci MV, Clatot F, Duhoux FP, Graffeo R, Teixeira L, Cordoba O, Sonnenblick A, Ferreira AR, Partridge AH, Di Meglio A, Saule C, Peccatori FA, Bruzzone M, t'Kint de Roodenbeke MD, Ameye L, Balmana J, Del Mastro L, Azim HA Jr. Clinical behavior and outcomes of breast cancer in young women with germline BRCA pathogenic variants. NPJ Breast Cancer. 2021 Feb 12;7(1):16. doi: 10.1038/s41523-021-00224-w.
- Borstelmann NA, Gray TF, Gelber S, Rosenberg S, Zheng Y, Meyer M, Ruddy KJ, Schapira L, Come S, Borges V, Cadet T, Maramaldi P, Partridge AH. Psychosocial issues and quality of life of parenting partners of young women with breast cancer. Support Care Cancer. 2022 May;30(5):4265-4274. doi: 10.1007/s00520-022-06852-7. Epub 2022 Jan 28.
- Sella T, Ruddy KJ, Carey LA, Partridge AH. Optimal Endocrine Therapy in Premenopausal Women: A Pragmatic Approach to Unanswered Questions. JCO Oncol Pract. 2022 Mar;18(3):211-216. doi: 10.1200/OP.21.00482. Epub 2021 Oct 12.
- Krasne M, Ruddy KJ, Poorvu PD, Gelber SI, Tamimi RM, Schapira L, Peppercorn J, Come SE, Borges VF, Partridge AH, Rosenberg SM. Coping strategies and anxiety in young breast cancer survivors. Support Care Cancer. 2022 Nov;30(11):9109-9116. doi: 10.1007/s00520-022-07325-7. Epub 2022 Aug 20.
- Rosenberg SM, Zheng Y, Gelber S, Ruddy KJ, Poorvu P, Sella T, Tamimi RM, Wassermann J, Schapira L, Borges VF, Come S, Peppercorn J, Sepucha KR, Partridge AH. Adjuvant endocrine therapy non-initiation and non-persistence in young women with early-stage breast cancer. Breast Cancer Res Treat. 2023 Feb;197(3):547-558. doi: 10.1007/s10549-022-06810-1. Epub 2022 Nov 27.
- Sella T, Zheng Y, Tan-Wasielewski Z, Rosenberg SM, Poorvu PD, Tayob N, Ruddy KJ, Gelber SI, Tamimi RM, Schapira L, Come SE, Peppercorn JM, Borges VF, Partridge AH, Ligibel JA. Body weight changes and associated predictors in a prospective cohort of young breast cancer survivors. Cancer. 2022 Sep 1;128(17):3158-3169. doi: 10.1002/cncr.34342. Epub 2022 Jul 1.
- Sella T, Fell GG, Miller PG, Gibson CJ, Rosenberg SM, Snow C, Stover DG, Ruddy KJ, Peppercorn JM, Schapira L, Borges VF, Come SE, Warner E, Frank E, Neuberg DS, Ebert BL, Partridge AH. Patient perspectives on testing for clonal hematopoiesis of indeterminate potential. Blood Adv. 2022 Dec 27;6(24):6151-6161. doi: 10.1182/bloodadvances.2022008376.
- Tesch ME, Rosenberg SM, Collins LC, Wong JS, Dominici L, Ruddy KJ, Tamimi R, Schapira L, Borges VF, Warner E, Come SE, Partridge AH. Clinicopathologic Features, Treatment Patterns, and Disease Outcomes in a Modern, Prospective Cohort of Young Women Diagnosed with Ductal Carcinoma In Situ. Ann Surg Oncol. 2022 Dec;29(13):8048-8057. doi: 10.1245/s10434-022-12361-y. Epub 2022 Aug 12.
- Waks AG, Kim D, Jain E, Snow C, Kirkner GJ, Rosenberg SM, Oh C, Poorvu PD, Ruddy KJ, Tamimi RM, Peppercorn J, Schapira L, Borges VF, Come SE, Brachtel EF, Warner E, Collins LC, Partridge AH, Wagle N. Somatic and Germline Genomic Alterations in Very Young Women with Breast Cancer. Clin Cancer Res. 2022 Jun 1;28(11):2339-2348. doi: 10.1158/1078-0432.CCR-21-2572.
- Lewinsohn R, Zheng Y, Rosenberg SM, Ruddy KJ, Tamimi RM, Schapira L, Peppercorn J, Borges VF, Come S, Snow C, Ginsburg ES, Partridge AH. Fertility Preferences and Practices Among Young Women With Breast Cancer: Germline Genetic Carriers Versus Noncarriers. Clin Breast Cancer. 2023 Apr;23(3):317-323. doi: 10.1016/j.clbc.2022.12.012. Epub 2022 Dec 22.
- Rath M, Li Q, Li H, Lindstrom S, Miron A, Miron P, Dowton AE, Meyer ME, Larson BG, Pomerantz M, Seo JH, Collins LC, Vardeh H, Brachtel E, Come SE, Borges V, Schapira L, Tamimi RM, Partridge AH, Freedman M, Ruddy KJ. Evaluation of significant genome-wide association studies risk - SNPs in young breast cancer patients. PLoS One. 2019 May 24;14(5):e0216997. doi: 10.1371/journal.pone.0216997. eCollection 2019.
- Schapira L, Zheng Y, Gelber SI, Poorvu P, Ruddy KJ, Tamimi RM, Peppercorn J, Come SE, Borges VF, Partridge AH, Rosenberg SM. Trajectories of fear of cancer recurrence in young breast cancer survivors. Cancer. 2022 Jan 15;128(2):335-343. doi: 10.1002/cncr.33921. Epub 2021 Oct 6.
- Dominici L, Hu J, Zheng Y, Kim HJ, King TA, Ruddy KJ, Tamimi RM, Peppercorn J, Schapira L, Borges VF, Come SE, Warner E, Wong JS, Partridge AH, Rosenberg SM. Association of Local Therapy With Quality-of-Life Outcomes in Young Women With Breast Cancer. JAMA Surg. 2021 Oct 1;156(10):e213758. doi: 10.1001/jamasurg.2021.3758. Epub 2021 Oct 13.
- Singh MP, Gupta S, Singh M, Ambrish C, Kurmi P, Gangwani DK, Naganna J, Sethuraman R, Dhumal V, Behera S, Patel PM, Patil DM, Lakhwani LK, Ghadge PS, Mehta SC, Joglekar SJ. Efficacy and Safety of Triple Fixed Dose Combination of Dapagliflozin + Sitagliptin + Metformin IR in Indian Patients with Type 2 Diabetes Mellitus: A Randomized, Phase 3 Study in Comparison with Dual FDC Sitagliptin + Metformin IR. Adv Ther. 2025 Oct;42(10):5187-5201. doi: 10.1007/s12325-025-03323-3. Epub 2025 Aug 19.
- Rosenberg SM, Zheng Y, Ruddy K, Poorvu PD, Snow C, Kirkner GJ, Meyer ME, Tamimi RM, Schapira L, Peppercorn J, Come S, Borges VF, Warner E, Gelber S, Collins L, Winer EP, Partridge AH. Helping ourselves, helping others: the Young Women's Breast Cancer Study (YWS) - a multisite prospective cohort study to advance the understanding of breast cancer diagnosed in women aged 40 years and younger. BMJ Open. 2024 Jul 1;14(6):e081157. doi: 10.1136/bmjopen-2023-081157.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2006年11月1日
初级完成 (估计的)
2035年1月1日
研究完成 (估计的)
2035年1月1日
研究注册日期
首次提交
2011年11月5日
首先提交符合 QC 标准的
2011年11月8日
首次发布 (估计的)
2011年11月9日
研究记录更新
最后更新发布 (实际的)
2026年2月3日
上次提交的符合 QC 标准的更新
2026年1月30日
最后验证
2026年1月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.