Apathy in Schizophrenia
L'Apathie Dans la schizophrénie: étude Neuropsychologique et Anatomique
Apathy, defined as a quantitative reduction of voluntary, goal-directed behaviours (GDB), is a core component of negative symptoms. It has been suggested that the physiopathology of apathy is not a single entity but may be multiple, depending on which specific process or macrofunction is disrupted during completion of GDB. In line with this notion, Levy and Dubois proposed dividing apathic syndromes into three subtypes of disrupted processing: 'a-motivation', 'cognitive inertia', and 'uncoupling'. In schizophrenia, apathy has been associated with executive dysfunction, functional impairment and poor outcome. However, the neurobiological underpinnings of apathy in schizophrenia are poorly understood.
Primary objective: confirm that chronic schizophrenic patients are apathic compared to healthy volunteers
Secondary objectives:
- investigate if apathy is related to a particular aspect of the disease (i.e. negative, positive symptomatology and/or deficit form)
- investigate if apathy correlates with executive dysfunction
- investigate if apathy is associated with a specific mechanism using an experimental task specially designed to investigate the different mechanism (i.e. 'a-motivation', 'cognitive inertia', and 'uncoupling')
- investigate if there is a volumetric abnormality affecting the executive system in apathic schizophrenic patients
- link these eventual volumetric abnormalities to prefrontal cortex-basal ganglia circuits according to a specific subtype of apathy in the apathic schizophrenic group
研究概览
研究类型
注册 (预期的)
联系人和位置
学习地点
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Paris、法国、75013
- 招聘中
- INSERM MEDU 945, Centre de Recherche-Institut du Cerveau et de la Moelle (CR-ICM), Hôpital de la Pitié Salpétrière
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
schizophrenic patients:
- outpatients of the Corentin Celton psychiatric service
- inpatients of the Corentin Celton Day Hospital Unit
healthy volunteers: community
描述
Inclusion Criteria (healthy volunteers):
- Male or Female aged 20 to 55 years old included
- Under French public assurance system
Exclusion Criteria (healthy volunteers):
- Personal history of neurological disorders
- Personal history of head injury
- Alcohol or substance abuse
- Under psychotropic drug
- Contraindication for MRI
Inclusion Criteria (schizophrenic patients):
- Male or Female aged 20 to 55 years old included
- Under French public assurance system
- diagnosis of schizophrenia according to the DSM-IV R criteria
- Duration of illness > 5 years
- clinical stability during the past 2 months (defined as no treatment modification or hospitalisation 2 months prior evaluation)
Exclusion Criteria (schizophrenic patients):
- Schizo-affective disorder
- Personal history of neurological disorders
- Personal history of head injury
- Alcohol or substance abuse
- Contraindication for MRI
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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健康志愿者
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chronic schizophrenic patients
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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apathy as measured by Starkstein's Apathy Evaluation Scale
大体时间:baseline
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baseline
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
neuropsychological performance
大体时间:baseline
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baseline
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clinical assessment (for patients only)
大体时间:baseline
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scores on evaluation scales (PANSS, SAPS, SANS, CDS, SDS)
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baseline
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volumetric brain abnormalities
大体时间:baseline
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voxel based morphometry
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baseline
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合作者和调查者
调查人员
- 首席研究员:Richard Levy, MD、INSERM MEDU 945, Centre de Recherche-Institut du Cerveau et de la Moelle (CR-ICM), Hôpital de la Pitié Salpétrière, 75013 Paris
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- C11-39
- 2011-A01610-41 (注册表标识符:IDRCB)
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