验证二氧化碳图作为 FloTrac 测量的心输出量变化的预测指标
本研究的目的是评估二氧化碳图与使用 FloTrac/EV1000 进行的可逆液体挑战、被动抬腿操作后无创测量心输出量的相关性,使用热稀释作为金标准。
主要假设是 ETCO2 增加与被动抬腿动作后 FloTrac/EV1000 测量的射血量增加之间的相关性为 0.8。
研究概览
详细说明
收集有关既往疾病、用药、手术类型、术前经食管超声心动图异常和动脉管路定位的数据。
在麻醉诱导之前,安装动脉管路。 麻醉诱导剂和剂量由主治麻醉师自行决定。 气管插管,麻醉回路和侧流 CO2 传感器连接到气管插管,正压通气以标准化参数开始:无吸气努力的控制辅助模式,潮气量 6-8 mL/kg,呼吸频率 8-10 /分钟和 5 毫米汞柱的 PEEP。 在 PLR 操作之前和期间不允许修改通气参数。 异氟醚和丙泊酚用于维持麻醉。 将 PA 导管(Paceport,Edwards Lifesciences,Irvine,California,USA)插入右颈内静脉。 如果安装了股线,则将 FloTrac/EV1000 连接到股线,如果未安装,则使用桡线进行微创连续心输出量监测。 记录了 CVP 波形的 a 波和 v 波纵横比。 检查 RV 波形是否存在异常迹象,例如非水平斜率限制模式(图 xx)18。 传感器全部放置在中胸水平,在使用 FloTrac/EV1000 测量 CO 之前执行“冲洗测试”,以确保系统没有共振或阻尼。
在基线时,在第一次 PLR 操作之前的手术室中,记录心率、收缩压、舒张压和平均动脉压、CVP 值、使用热稀释法一式三份测量的 CI 和 FloTrac 衍生变量。 这些变量包括 FloTrac/EV1000 测量的 CO 索引 CO 和 SVV。 在 PLR 开始后 1、3 和 5 分钟记录相同的变量,除了通过热稀释的 CI 仅在 3 分钟再次测量一次,而 EtCO2 每 12 秒记录一次。 在基线和 PLR 操作期间检查 EtCO2 曲线,以确保 EtCO2 的变化与吸入 CO2 的变化、呼吸机或回路故障或气道阻力增加无关。
从 CPB 撤机后,采取相同的措施两次:打开胸腔,达到血流动力学稳定后,取出 CPB 插管并关闭胸腔。
在 ICU 中,执行了两次额外的 PLR 操作,中间间隔 30 分钟。 记录先前描述的测量集。 还记录了心外膜临时起搏器、升压药(剂量和类型)、血管扩张剂(剂量和类型)的使用。
研究类型
注册 (实际的)
联系人和位置
学习地点
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Quebec
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Montreal、Quebec、加拿大、H1T 1C8
- Montreal Heart Institute
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
纳入标准:
- 年满 18 周岁且接受过心脏或主动脉手术的人
排除标准:
- 起搏器
- 下肢截肢或下肢缺失
- 中度三尖瓣功能不全
- 数据测量期间术前心律失常或长期心律失常
- 中度主动脉瓣反流
- 已知深静脉血栓形成
- 主动脉内球囊泵
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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被动抬腿
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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可逆液体挑战、被动抬腿期间 ETCO2 升高与心输出量之间的相关性
大体时间:参与者将从他们到达手术室到术后 2 小时在重症监护室接受跟踪
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被动抬腿后 ETCO2 增加与 FloTrac/EV1000 测量的射血量增加之间的相关性为 0.8
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参与者将从他们到达手术室到术后 2 小时在重症监护室接受跟踪
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次要结果测量
结果测量 |
大体时间 |
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Flotrac/EV1000 测量的指数心输出量变化与可逆液体挑战、被动抬腿期间热稀释法测量的心输出量变化之间的相关性
大体时间:参与者将从他们到达手术室到术后 2 小时在重症监护室接受跟踪
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参与者将从他们到达手术室到术后 2 小时在重症监护室接受跟踪
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在可逆液体挑战、被动抬腿期间通过热稀释法测量的二氧化碳图升高与指数心输出量之间的相关性
大体时间:参与者将从他们到达手术室到术后 2 小时在重症监护室接受跟踪
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参与者将从他们到达手术室到术后 2 小时在重症监护室接受跟踪
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Flotrac/EV1000 在可逆液体挑战、被动抬腿期间测量的二氧化碳图变化与指数心输出量之间的相关性
大体时间:参与者将从他们到达手术室到术后 2 小时在重症监护室接受跟踪
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参与者将从他们到达手术室到术后 2 小时在重症监护室接受跟踪
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合作者和调查者
出版物和有用的链接
一般刊物
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- Broch O, Renner J, Gruenewald M, Meybohm P, Schottler J, Steinfath M, Malbrain M, Bein B. A comparison of third-generation semi-invasive arterial waveform analysis with thermodilution in patients undergoing coronary surgery. ScientificWorldJournal. 2012;2012:451081. doi: 10.1100/2012/451081. Epub 2012 Jul 31.
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研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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