The Complement Lectin Pathway After Cardiac Arrest
The Complement Lectin Pathway in Patients Resuscitated After Cardiac Arrest
This study includes comatose survivors of out-of-hospital cardiac arrest treated with 24 hours or 48 hours of targeted temperature management.
The overall aim is to evaluate the importance of plasma complement protein concentrations in patients resuscitated after out-of-hospital cardiac arrest and treated with 24 hours or 48 hours of targeted temperature management.
The specific aim is to evaluate:
- the concentration of plasma lectin pathway proteins the first, second and third day after cardiac arrest
- the relation between concentration of plasma lectin pathway proteins and mortality
- if prolonged targeted temperature management influences the concentration of plasma lectin pathway proteins
This study is a sub-study to the trial entitled: "Time-differentiated targeted temperature management (TTH48) (ClinicalTrials.gov Identifier: NCT01689077)"
The following Complement Lectin Pathway proteins will be measured: Mannan-Binding-Lectin, M-ficolin, H-ficolin, CL-L1, MASP-1, MASP-2, MASP-3, MAp19 and MAp44.
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Aarhus、丹麦、8000
- Department of Biomedicine, Aarhus University
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Aarhus、丹麦、8200
- Department of Anesthesiology and Intensive Care, Aarhus University Hospital
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Aarhus、丹麦、8200
- Department of Clinical Biochemistry, Aarhus University Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Out-of-Hospital Cardiac Arrest of presumed cardiac cause
- Return of spontaneous circulation (ROSC)
- Glasgow Coma Score < 8
- Age > 18 years and < 80 years
Exclusion Criteria:
- > 60 minutes from the circulatory collapse to ROSC
- Time interval > 4 hours from cardiac arrest to initiation of targeted temperature management
- Terminal illness
- Coagulation disorder
- Unwitnessed asystolia
- Cerebral performance category 3-4 before the cardiac arrest
- Severe persistent cardiogenic shock
- Pregnancy
- Persistent cardiogenic shock (systolic bloodpressure < 80 despite inotropic treatment)
- New apoplexy or cerebral hemorrhage
- Lack of consent from the relatives
- Lack of consent from the general practitioner
- Lack of consent from the patient
学习计划
研究是如何设计的?
设计细节
- 主要用途:基础科学
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:单身的
武器和干预
参与者组/臂 |
干预/治疗 |
---|---|
有源比较器:24 hour of targeted temperature management
Patients resuscitated after cardiac arrest and treated with 24 hours of targeted temperature management (33 degree Celsius)
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实验性的:48 hour of targeted temperature management
Patients resuscitated after cardiac arrest and treated with 48 hours of targeted temperature management (33 degree Celsius)
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
MASP-2 concentration in plasma
大体时间:48 hours
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48 hours
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
MASP-2 concentration in plasma
大体时间:24 hours, 48 hours and 72 hours
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24 hours, 48 hours and 72 hours
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MASP-2 concentration in plasma
大体时间:24 hours, 48 hours, 72 hours
|
MASP-2 concentration in plasma compared with 30-day mortality
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24 hours, 48 hours, 72 hours
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MASP-2 concentration in plasma
大体时间:24 hours to 72 hours
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24 hours to 72 hours
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MASP-1 concentration in plasma
大体时间:24 hours, 48 hours and 72 hours
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24 hours, 48 hours and 72 hours
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MASP-1 concentration in plasma
大体时间:24 hours to 72 hours
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24 hours to 72 hours
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MASP-1 concentration in plasma
大体时间:24 hours, 48 hours, 72 hours
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MASP-1 concentration in plasma compared with 30-day mortality
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24 hours, 48 hours, 72 hours
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MASP-3 concentration in plasma
大体时间:24 hours, 48 hours and 72 hours
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24 hours, 48 hours and 72 hours
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MASP-3 concentration in plasma
大体时间:24 hours to 72 hours
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24 hours to 72 hours
|
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MASP-3 concentration in plasma
大体时间:24 hours, 48 hours, 72 hours
|
MASP-3 concentration in plasma compared with 30-day mortality
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24 hours, 48 hours, 72 hours
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Mannan-Binding-Lectin concentration in plasma
大体时间:24 hours, 48 hours and 72 hours
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24 hours, 48 hours and 72 hours
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Mannan-Binding-Lectin concentration in plasma
大体时间:24 hours to 72 hours
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24 hours to 72 hours
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Mannan-Binding-Lectin concentration in plasma
大体时间:24 hours, 48 hours, 72 hours
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Mannan-Binding-Lectin concentration in plasma compared to 30-day mortality
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24 hours, 48 hours, 72 hours
|
MAp44 concentration in plasma
大体时间:24 hours, 48 hours and 72 hours
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24 hours, 48 hours and 72 hours
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Map44 concentration in plasma
大体时间:24 hours to 72 hours
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24 hours to 72 hours
|
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MAp44 concentration in plasma
大体时间:24 hours, 48 hours, 72 hours
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MAp44 concentration in plasma compared with 30-day mortality
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24 hours, 48 hours, 72 hours
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MAp19 concentration in plasma
大体时间:24 hours, 48 hours and 72 hours
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24 hours, 48 hours and 72 hours
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MAp19 concentration in plasma
大体时间:24 hours to 72 hours
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24 hours to 72 hours
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MAp19 concentration in plasma
大体时间:24 hours, 48 hours, 72 hours
|
MAp19 concentration in plasma compared with 30-day mortality
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24 hours, 48 hours, 72 hours
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H-ficolin concentration in plasma
大体时间:24 hours, 48 hours and 72 hours
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24 hours, 48 hours and 72 hours
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H-ficolin concentration in plasma
大体时间:24 hours to 72 hours
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24 hours to 72 hours
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H-ficolin concentration in plasma
大体时间:24 hours, 48 hours, 72 hours
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H-ficolin concentration in plasma compared with 30-day mortality
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24 hours, 48 hours, 72 hours
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M-ficolin concentration in plasma
大体时间:24 hours, 48 hours and 72 hours
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24 hours, 48 hours and 72 hours
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M-ficolin concentration in plasma
大体时间:24 hours to 72 hours
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24 hours to 72 hours
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M-ficolin concentration in plasma
大体时间:24 hours, 48 hours, 72 hours
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M-ficolin concentration in plasma compared with 30-day mortality
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24 hours, 48 hours, 72 hours
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CL-L1 concentration in plasma
大体时间:24 hours, 48 hours and 72 hours
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24 hours, 48 hours and 72 hours
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CL-L1 concentration in plasma
大体时间:24 hours to 72 hours
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24 hours to 72 hours
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CL-L1 concentration in plasma
大体时间:24 hours, 48 hours, 72 hours
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CL-L1 concentration in plasma compared with 30-day mortality
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24 hours, 48 hours, 72 hours
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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