Effects of Desflurane and Propofol During Lung Volume Reduction Surgery
A Comparison of the Anesthetic and Hemodynamic Effects of a Volatile Anesthetic (Desflurane) and an Intravenous Anesthetic (Propofol), During Lung Volume Reduction Surgery
研究概览
详细说明
The anesthetic technique for lung volume reduction surgery consists of a thoracic epidural in combination with a general anesthetic. The thoracic epidural is routine for this operation and allows administration of local anesthetics and painkillers in the epidural space which results in profound pain relief in the area of surgery. The epidural is routinely used for pain control during the surgery and after the surgery when the patient is awake.
The general anesthetic used may be a volatile agent (gas for example Desflurane), which is administered through the anesthesia machine, or an intravenous anesthetic agent, which is administered into a vein through an intravenous line as a continuous infusion (example Propofol). The use of an anesthetic agent and an epidural often causes a decrease in blood pressure which is treated with medication. The investigators are comparing the two anesthetic techniques regarding their effect on blood pressure and the amount of medication needed to treat it.
研究类型
注册 (实际的)
阶段
- 第四阶段
联系人和位置
学习地点
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New York
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New York、New York、美国、10032
- Columbia University Irving Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Scheduled to undergo lung volume reduction surgery (LVRS)
Exclusion Criteria:
- Does not sign a study consent form
学习计划
研究是如何设计的?
设计细节
- 主要用途:其他
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
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有源比较器:Propofol
Patients will receive Propofol as an intravenous (IV) agent, which is administered into a vein through an IV line as a continuous infusion.
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Intravenous administration
其他名称:
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有源比较器:Desflurane
Patients will receive Desflurane as a gas that is administered through an anesthesia machine.
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Volatile administration
其他名称:
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Time of discontinuation of anesthetic to eye opening
大体时间:Up to 30 minutes (during procedure)
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Measured in minutes
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Up to 30 minutes (during procedure)
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Time of discontinuation of anesthetic to tidal volume (TV) 300ml
大体时间:Up to 30 minutes (during procedure)
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Measured in minutes
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Up to 30 minutes (during procedure)
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Time of discontinuation of anesthetic to extubation
大体时间:Up to 30 minutes (during procedure)
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Measured in minutes
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Up to 30 minutes (during procedure)
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Duration of intensive care unit (ICU) stay
大体时间:Up to 1 month from procedure
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Measured in days
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Up to 1 month from procedure
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Duration of hospital stay
大体时间:Up to 1 month from procedure
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Measured in days
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Up to 1 month from procedure
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合作者和调查者
调查人员
- 首席研究员:Bessie Kachulis, MD、Columbia University
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
Propofol的临床试验
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Kaohsiung Medical University Chung-Ho Memorial...Tri-Service General Hospital招聘中