用于化疗引起的周围神经病变的可穿戴式焦点振动

实验性的：局部振动疗法

Myovolt 提供频率在 50-80 赫兹之间的振动。 Myovolt 强度将设置为参与者初始 Myovolt 感知阈值的 2 倍。 如果刺激感觉不强烈，参与者将被要求手动增加强度，直到感觉强烈但舒适。

设备：局部振动疗法

Myovolt 是一种可穿戴康复设备，可将振动传递到磨损电机的身体区域。 要求参与者每天两次将振动应用于特定腿部位置，每次约 30 分钟，并使用提供的日志记录他们的反应。 他们可能会被要求尝试在不同位置应用设备或使用不同的振动参数（脉冲频率或强度）。

其他名称：

• 妙伏特

Feasibility of Enrollment

Percent of interested individuals who enrolled.

Adherence to Myovolt Focal Vibration

Number of completed sessions the intervention was worn, as a percentage of the number of sessions prescribed.

癌症治疗/妇科肿瘤组的功能评估-神经毒性-12 (FACT-GOG/NTX-12) 症状清单

FACT-GOG/Ntx-12 是 CIPN 症状和功能障碍以及相关生活质量的综合测量，评分从 0 到 48，其中较高的分数表示较差的神经病变症状。

神经病总症状评分 6 (NTSS-6)

NTSS-6 将神经性症状（严重程度和频率）分为 6 个类别。 分数范围从 0 到 21.96，分数越高表示症状负担越高。

癌症治疗/妇科肿瘤组的功能评估 - 神经毒性 - 12 (FACT-GOG/NTX-12) 身体健康子量表

FACT-GOG/Ntx-12 PWB 子量表是身体症状和功能的患者报告量表。 从 0 到 28 分，得分越高表明幸福感越好。

癌症治疗/妇科肿瘤组-神经毒性-12 (FACT-GOG/NTX-12) 功能健康子量表的功能评估

FACT-GOG/Ntx-12 FWB 子量表是一种功能健康的患者报告测量方法，其中包含有关工作、休闲和睡眠的问题，以及生活质量 (QoL) 评级的摘要。 分数范围从 0 到 28，分数越高表示幸福感和生活质量越好。

Patient Neurotoxicity Questionnaire (PNQ)

The PNQ grades the extent of sensory and motor neuropathy in cancer cohorts scored from grade A (no neuropathy, also Grade 0) to grade E (severe neuropathy, also Grade 4). Sensory and motor severity are rated separately.

Global Rating of Change (GROC) Scale

The GROC scale is a universal clinical outcome providing a simple but comprehensive "umbrella" patient-perspective of change. Scores on a 9-point ordinal scale centered around 0 (Unchanged) ranged from -4 (very much worse) to 0 (unchanged) to +4 (very much better).

Manual Muscle Testing (MMT) of Toes

MMT assesses muscle strength by an assessor applying pressure against the hallux as the participant lifts and holds 1st metatarsophalangeal extension. Strength is rated from 0 (weakest) to 5 (strongest). Change of 1 grade from the baseline values is categorized as improvement or decline.

Change in Toe Strength Using a Proprietary Quantifiable Toe Measurement Device, Quantification of Hallux Extension Strength or QuHalEx(TM), U.S. Patent 11402284 Issued to the University of Oklahoma on 08/02/2022, and Provisional Patent 63/627,850.

QuHalEx(TM) measures toe strength by reading force measurements (higher is stronger) when participants sit with foot strapped on a portable base of a proprietary University of Oklahoma QuHalEx(TM) load-cell prototype device (U.S. Patent 11402284 issued to the University of Oklahoma on 08/02/2022, and provisional patent 63/627,850). With the great toe inserted into a cap, the participant pulls up and holds isometrically for a few seconds. The peak force is the highest value recorded over the hold time. We report the change in peak force from baseline to the 6-week visit.

Vibration Perception Threshold Using Biothesiometer

Vibratory threshold is measured by a non-invasive vibrating probe (biothesiometer) placed on the skin and increased from 0 Hz until the amplitude when the participant first reports detection (eyes closed) or the maximum amplitude available on the biothesiometer scale (50 Volts). Higher indicates worse sensation.