特定于患者的计算步行模型在改善盆腔肉瘤患者的手术和康复治疗中的作用
CPRIT：使用计算模型优化盆腔肉瘤的手术和康复治疗
This trial studies the development of patient-specific computational walking models to improve the surgical planning and rehabilitation treatment of patients with pelvic sarcomas. Every pelvis and pelvic sarcoma are different, and the orthopedic oncologist faces significant challenges when removing a tumor from the complex anatomy of the pelvis. These challenges make it difficult to achieve excellent oncological and functional outcomes together. Computational walking models may be used to predict the best combination of surgical methods and how to implement them to maximize each patient's post-surgery walking function.
研究概览
详细说明
PRIMARY OBJECTIVES:
I. To develop patient-specific computational walking models to predict the optimal combination of pelvic sarcoma surgical and rehabilitation decisions that will maximize each patient's post-surgery walking function.
II. To collect experimental movement and imaging data prospectively and retrospectively from individuals who have already received, or are going to receive, a type I or type II hemipelvectomy.
III. To use the data to develop computational modeling and simulation methodologies that can predict an individual patient's post-surgery walking function given pre-surgery movement and imaging data and the surgical decisions made by the surgeon.
OUTLINE:
Patients undergo walking function assessment using optical motion capture and bi-plane dynamic X-ray imaging pre- and post-hemipelvectomy.
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Valerae O Lewis, BS,MD
- 电话号码：(713) 792-5073
- 邮箱：volewis@mdanderson.org
学习地点
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Texas
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Houston、Texas、美国、77030
- 招聘中
- M D Anderson Cancer Center
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接触：
- Valerae O. Lewis
- 电话号码：713-745-4117
- 邮箱：volewis@mdanderson.org
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首席研究员：
- Valerae O. Lewis
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Patients who have received or are scheduled to receive an internal hemipelvectomy with or without reconstruction at UT MD Anderson Cancer Center.
- Patients who are 18 years of age and older
Exclusion Criteria:
- Patients who have undergone an external (hindquarter amputated), or an isolated type III internal hemipelvectomy.
- Previous surgery or significant injury to either hip (prospective patients only)
- Relevant surgery, procedure, injury, or condition in the last two years which may affect hip pain or general movement patterns on either side (prospective patients only)
- Pregnant women or women nursing an infant
- Persons with a pacemaker, hearing aid, aneurysm clips or artificial heart valves, and other forms of loose metal implants will be excluded from the study as assessed by a pre-MRI questionnaire administered by the MRI technician at the time of the scan.
- Radiological exclusion criteria (assessed after MR scan is conducted on the first visit, prior to DSX/CT radiation exposure): evidence on preliminary MRI of fracture, slipped capital femoral epiphysis (SCFE), masses, lesions, or other anomalies not consistent with an FAI diagnosis.
学习计划
研究是如何设计的？
设计细节
- 主要用途：支持治疗
- 分配：非随机化
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Supportive care (walking function test, X-ray)
Patients undergo walking function assessment using optical motion capture and bi-plane dynamic X-ray imaging pre- and post-hemipelvectomy. |
Undergo walking function assessment with optical motion capture Undergo bi-plane dynamic X-ray imaging
其他名称：
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无干预：Retrospective Group
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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建立特定于患者的计算模型，为手术决策提供信息，并设计可最大限度提高术后功能的定制植入物。
大体时间：通过学习完成，平均1年
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通过学习完成，平均1年
|
合作者和调查者
调查人员
- 首席研究员：Valerae O Lewis、M.D. Anderson Cancer Center
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.