Cognitive Function and Brain Connectivity in CAS Patients:a Rs-fMRI Study
Cognitive Function and Brain Connectivity in Carotid Artery Stenting Patients:a Rs-fMRI Study
研究概览
详细说明
Carotid artery stenting (CAS) can significantly decrease the incidence of ischemic stroke in patients with severe carotid artery stenosis has been confirmed in large randomized controlled studies (1, 2).Previous studies showed carotid artery stenosis is closely related to cognitive dysfunction, including asymptomatic carotid artery stenosis(≥70%).Cognitive impairment is one of the most serious problem facing the elderly. The impact on cognitive function in patients with CAS has been discussed by many researchers, however the effect still remained conflicting.
In past few years, several imaging techniques, such as resting-state functional MRI (R-fMRI), had been increasingly used to study cognitive impairment in humans. In this study, we evaluated the cognition performance in severe carotid artery stenosis patients undergoing CAS and explored the mechanisms underlying the cognition changes by the Rs-fMRI.
Inclusion criteria:
- age between 55 years and 80 years
- unilateral internal carotid artery stenotic degree ≥ 70%
- right-hand-dominant
- free of dementia, and depression
- modified Rankin Scale: 0 or 1
- education ≥6 years
- obtained written informed consent.
Exclusion criteria:
- contralateral internal carotid artery stenosis ≥ 50%
- posterior circulation diseases
- MMSE < 26, which is a cut-off value for mild cognitive impairment
- severe systemic diseases and neuropsychiatric diseases (such as congestive heart failure)
- any contraindications for MRI scan (e.g., metal implants)
- Non atherosclerotic stenosis, such as dissection, vasculitis.
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名:Renjie Ji, Master
- 电话号码:+86 13738101002
- 邮箱:zjujirenjie@zju.edu.cn
研究联系人备份
- 姓名:Hanfeng Chen, Master
- 电话号码:+86 18768115416
- 邮箱:chf0106@foxmail.com
学习地点
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Zhejiang
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Hangzhou、Zhejiang、中国、310016
- 招聘中
- The First Affiliated Hospital of Zhejiang University
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首席研究员:
- Benyan Luo, PhD
-
接触:
- 仁杰 计
- 电话号码:13738101002
-
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- age between 55 years and 80 years
- unilateral internal carotid artery stenotic degree ≥ 70%
- right-hand-dominant
- free of stroke, TIA, dementia, and depression
- modified Rankin Scale: 0 or 1
- education ≥6 years
- obtained written informed consent.
Exclusion Criteria:
- contralateral internal carotid artery stenosis ≥ 50%
- posterior circulation diseases
- MMSE < 26, which is a cut-off value for mild cognitive impairment
- severe systemic diseases and neuropsychiatric diseases (such as congestive heart failure and history of stroke)
- any contraindications for MRI scan (e.g., metal implants)
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Montreal Cognitive Assessment, MOCA
大体时间:before CAS(within 1 week)
|
use MOCA to assess the cognition before CAS
|
before CAS(within 1 week)
|
Mini-mental State Examination,MMSE
大体时间:before CAS(within 1 week)
|
use MMSE to assess the cognition before CAS
|
before CAS(within 1 week)
|
Montreal Cognitive Assessment, MOCA
大体时间:3 months after CAS
|
use MOCA to assess the cognition after CAS
|
3 months after CAS
|
Mini-mental State Examination,MMSE
大体时间:3 months after CAS
|
use MMSE to assess the cognition after CAS
|
3 months after CAS
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Digit Symbol Test
大体时间:before CAS(within 1 week)
|
use to assess the cognition before CAS
|
before CAS(within 1 week)
|
Digit Symbol Test
大体时间:3 months after CAS
|
use to assess the cognition after CAS
|
3 months after CAS
|
Trail Making Test A/B
大体时间:before CAS(within 1 week)
|
use to assess the cognition before CAS
|
before CAS(within 1 week)
|
Trail Making Test A/B
大体时间:3 months after CAS
|
use to assess the cognition after CAS
|
3 months after CAS
|
digital span test
大体时间:before CAS(within 1 week)
|
use to assess the cognition before CAS
|
before CAS(within 1 week)
|
digital span test
大体时间:3 months after CAS
|
use to assess the cognition after CAS
|
3 months after CAS
|
合作者和调查者
调查人员
- 首席研究员:Benyan Luo, PhD、Zhejiang University
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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