心肺康复对 COVID 19 后综合征参与者的影响。

有源比较器：Center-based rehabilitation(Control)

The face-to-face intervention group will perform pulmonary rehabilitation at the Center-based rehabilitation.

其他：Center-based rehabilitation

Both programmes lasted 12 weeks, with three sessions per week and a total of 36 sessions, and both were designed to address muscle strength, muscular fatigue and functional capacity. The centre-based protocol was developed from previously published clinical trial protocols with those objectives. It was delivered in a dedicated outpatient clinic by a physiotherapist specialized in the programme, in groups of up to three participants, always in the morning. Each session lasted approximately 80 to 90 minutes and comprised: warm-up on a treadmill or cycle ergometer (5 min); aerobic training on a treadmill or cycle ergometer (30 to 45 min); loaded strength and muscular-endurance training of the upper and lower limbs (30 min), addressing the muscle groups used in daily activities through frontal and lateral raises, flexion and extension, functional diagonal movements, squats, and dorsiflexion and plantar flexion, performed as three sets of each exercise with a 1-minute interval between sets:

有源比较器：Home-based rehabilitation (Experimental)

The home-based intervention group will carry out home intervention through a self-explanatory exercise booklet.

其他：Home-based Intervention

The home-based protocol comprised breathing exercises, stretching, muscle strengthening, balance and aerobic training, illustrated in a booklet. The booklet was delivered after the baseline evaluation and its execution was explained by a physiotherapist specialized in rehabilitation sciences in a face-to-face session. Every week the same professional made telephone contact to answer questions about the training, verify the regularity of the exercises and, where necessary, give advice. The intervention evaluated is therefore this combined package of booklet, initial instruction and weekly telephone monitoring. All exercises were designed to be simple and of low risk, at no cost to participants, and no equipment was provided; participants were advised to exercise preferably in the morning and in comfortable clothing. Each session lasted approximately 80 to 90 minutes and comprised: pursed-lip breathing, consisting of nasal inspiration with the mouth closed followed by expiration through

Functional Capacity

By 6MWD following the ERS/ATS field walking test

Respiratory muscle function (MIP)

MIP will be measure according to the ATS/ERS statement on respiratory muscle testing

Peripheral muscle function

Quadriceps strength will be assessed by a one-repetition-maximum (1-RM) test on an extension chair and quadriceps endurance will be assessed after 30 minutes of rest as the time for which a load corresponding to 40% of the 1-RM could be sustained isometrically until task failure (isometric endurance, in seconds)

Daily living activity

It will be evaluated by the Post-COVID Function Scale(PCFS)

改善生活质量

生活质量评估将使用包含 36 个项目的通用工具进行，该工具在巴西得到验证，称为 SF-36（短期健康调查）。