阻力训练适应性与咖啡因摄入
2026年7月12日 更新者：Abdullah Demirli、Istanbul University - Cerrahpasa
不同咖啡因补充策略对阻力训练适应性影响的研究
这项随机、双盲、安慰剂对照交叉试验研究了三种不同咖啡因补充策略对180名未接触过咖啡因、不活跃的年轻成年男性进行抗阻训练诱导适应的效果。
参与者将接受两个为期4周的监督式抗阻训练计划，中间间隔2周的洗脱/交叉期。
三种咖啡因策略为：(1) 每日恒定低-中剂量补充（3毫克/千克/天），(2) 逐渐递增剂量（数周内从3至6毫克/千克），(3) 仅在训练日补充咖啡因（3毫克/千克/天）。
主要结局指标包括无创测量的综合合成代谢与肥大指标（D2O衍生的血浆蛋白质组学分次合成率、DXA肌肉体积）以及力量指标。
次要结局指标包括激素反应（胰岛素、皮质醇、睾酮、IGF-1）、睡眠/恢复参数以及不良事件。
研究概览
地位
完全的
详细说明
背景：咖啡因是一种公认的急性运动能力增强剂，当以典型的增效剂量（约3-6毫克/公斤，运动前约60分钟摄入）摄入时，可可靠地提高耐力、力量和抗阻运动表现。
然而，咖啡因是否对肌肉蛋白质平衡和肥大产生直接生物学效应仍不清楚。
规律摄入咖啡因会产生部分生理耐受性，这意味着长期补充可能产生与急性摄入不同的结果。
目的：本研究探讨三个转化性问题：(1) 每日恒定低-中剂量摄入是否能增强训练适应性？
(2) 通过克服耐受性，逐渐递增剂量的策略是否能产生更大效果？
(3) 仅在训练日摄入咖啡因是否能保留急性增效作用，同时限制耐受性和睡眠干扰？
方法：180名未接触过咖啡因、身体不活跃的18-30岁年轻成年男性将被随机分配到三种咖啡因补充策略之一（每种策略n=60）。
在每种策略中，30名参与者将接受咖啡因，30名将接受安慰剂，持续4周。
经过2周的洗脱期/交叉后，干预措施将互换。
所有参与者将每周进行3次监督下的抗阻训练。
结果：主要终点包括氘氧化物（D2O）衍生的血浆蛋白质组学分数合成率（FSR）、DXA测量的瘦组织质量和肌肉体积、最大力量（卧推和深蹲的1RM或3RM）以及训练量指标。
次要结果包括激素和代谢时间进程、睡眠质量、主观恢复评分和不良事件监测。
统计分析：将使用线性混合模型分析数据。
研究类型
介入性
注册 (实际的)
120
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
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Avcilar
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Istanbul、Avcilar、土耳其（türkiye）、34010
- Istanbul University-Cerrahpasa, Faculty of Sport Sciences Performance Laboratory
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
接受健康志愿者
是的
描述
纳入标准：
- 男性，年龄在18-30岁之间
- 无咖啡因使用史或日常摄入量极低（<50毫克/天）
- 过去6个月内未参与定期抗阻训练计划
- 体重指数（BMI）在18.5-30千克/平方米之间
- 愿意定期参加所有训练和测试环节
- 在充分了解研究内容后提供书面知情同意
排除标准：
- 患有心血管、代谢、肾脏、肝脏或其他严重慢性疾病
- 确诊的精神障碍或严重咖啡因不耐受/过敏
- 使用影响咖啡因代谢或肌肉合成代谢的药物（如β受体阻滞剂、抗抑郁药、合成类固醇）
- 存在妨碍安全抗阻训练的肌肉骨骼损伤
- 吸烟或饮酒水平可能影响研究结果
- 同时参与另一项运动干预研究
- 无法耐受DXA扫描、血液采样或D2O摄入程序
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：三倍
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Strategy 1: Constant Daily Dose
Participants receive caffeine at a constant daily dose of 4 mg/kg/day for 10 weeks.
Supervised resistance training is performed 3 times per week for 10 weeks.
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Oral caffeine capsule at 4 mg/kg body weight, consumed daily approximately 60 minutes before training sessions (on training days) or at the same time of day (on rest days).
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实验性的：Strategy 2: Escalating Dose
Participants receive caffeine at a gradually escalating dose, starting at 2 mg/kg/day in week 1 and increasing to 6 mg/kg/day by week 10 (1 mg/kg every 2 weeks).
Supervised resistance training is performed 3 times per week for 10 weeks.
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• Oral caffeine starting at 2 mg/kg/day and increasing incrementally to reach 6 mg/kg/day by week 10.
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实验性的：Strategy 3: Training Days Only
Participants receive caffeine at 4 mg/kg only on training days (3 times per week) for 10 weeks.
Supervised resistance training is performed 3 times per week for 10 weeks.
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Oral caffeine capsule at 4 mg/kg body weight, consumed only on training days approximately 60 minutes before exercise.
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安慰剂比较：Placebo
Participants receive 250 mg/day cellulose for 10 weeks.
Supervised resistance training is performed 3 times per week for 10 weeks.
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Oral placebo capsule (250 mg cellulose), consumed daily approximately 60 minutes before training sessions (on training days) or at the same time of day (on rest days).
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Change in Lean Body Mass Measured by DXA
大体时间：Baseline and post-test (after completing 10 weeks of interventions)
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Change in total lean body mass measured using dual-energy X-ray absorptiometry (DXA), reported in kilograms.
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Baseline and post-test (after completing 10 weeks of interventions)
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Change in Fat Mass Measured by DXA
大体时间：Baseline and post-test (after completing 10 weeks of interventions)
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Change in fat mass measured using DXA.
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Baseline and post-test (after completing 10 weeks of interventions)
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Maximal Strength
大体时间：Baseline, and post-test (after completing 10 weeks of interventions)
|
Measure by one-repetition maximum (1-RM) on a lower body (Smith machine Back Squat) and two upper body (Bench Press machine and Lat Pulldown machine) exercises.
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Baseline, and post-test (after completing 10 weeks of interventions)
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Total Training Volume Load
大体时间：During the intervention period (all training sessions).
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Total training volume load calculated as the sum of lifted load using the formula (kilograms × repetitions × sets) accumulated during each intervention period.
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During the intervention period (all training sessions).
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Change in Skeletal Muscle Thickness
大体时间：Baseline and post-test (after completing 10 weeks of interventions)
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Change in skeletal muscle thickness measured using B-mode ultrasound, reported in mm.
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Baseline and post-test (after completing 10 weeks of interventions)
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Muscular endurance
大体时间：Baseline, and post-test (after completing 10 weeks of interventions)
|
It will be measured by a repetitions-to-failure test on the Smith machine back squat using a load corresponding to 60% of the current 1RM.
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Baseline, and post-test (after completing 10 weeks of interventions)
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Neuromuscular function
大体时间：Baseline and post-test (after completing 10 weeks of interventions)
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It will be measured by the countermovement jump (CMJ) test on a force platform.
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Baseline and post-test (after completing 10 weeks of interventions)
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Resting concentrations of testosterone
大体时间：Baseline, and post-test (after completing 10 weeks of interventions)
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They will be measured using standard biochemical analyses.
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Baseline, and post-test (after completing 10 weeks of interventions)
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Plasma epinephrine responses to exercise
大体时间：During the first training session of Week 1 and the final training session of Week 10, at three time points: (1) pre-supplementation, (2) immediately before exercise and (3) immediately after exercise.
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They will be measured using standard biochemical analyses.
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During the first training session of Week 1 and the final training session of Week 10, at three time points: (1) pre-supplementation, (2) immediately before exercise and (3) immediately after exercise.
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Recovery
大体时间：Before each of the 30 training sessions during the study.
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It will be assessed using the validated 0-10 Perceived Recovery Status Scale (0 to 2: very poorly recovered, 3 to 4: poorly recovered, 5 to 6: adequately recovered, 7 to 8: well recovered, and 9 to 10: fully recovered).
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Before each of the 30 training sessions during the study.
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Adverse Events
大体时间：From initiation of the 4-week caffeine abstinence period through completion of the post-intervention assessments, monitored throughout the study (approximately 16 weeks).
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Adverse events will be assessed using a standardized questionnaire administered throughout the study.
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From initiation of the 4-week caffeine abstinence period through completion of the post-intervention assessments, monitored throughout the study (approximately 16 weeks).
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Sleep quality
大体时间：Baseline and post-test (after completing 10 weeks of interventions).
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It will be assessed by the Pittsburgh Sleep Quality Index (PSQI).
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Baseline and post-test (after completing 10 weeks of interventions).
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Rate of perceived exertion
大体时间：After each supervised training session, participants were assessed throughout the 10-week intervention period (30 training sessions).
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Assessed using the Borg Category-Ratio (CR10) Scale, ranging from 0 ("nothing at all") to 10 ("maximal").
Participants will report their perceived exertion after each supervised training session.
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After each supervised training session, participants were assessed throughout the 10-week intervention period (30 training sessions).
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Resting concentrations of insulin-like growth factor-1 (IGF-1)
大体时间：Baseline, and post-test (after completing 10 weeks of interventions)
|
They will be measured using standard biochemical analyses.
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Baseline, and post-test (after completing 10 weeks of interventions)
|
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Resting concentrations of cortisol
大体时间：Baseline, and post-test (after completing 10 weeks of interventions)
|
They will be measured using standard biochemical analyses.
|
Baseline, and post-test (after completing 10 weeks of interventions)
|
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Resting concentrations of creatine kinase
大体时间：Baseline, and post-test (after completing 10 weeks of interventions)
|
They will be measured using standard biochemical analyses.
|
Baseline, and post-test (after completing 10 weeks of interventions)
|
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Serum cortisol responses to exercise
大体时间：During the first training session of Week 1 and the final training session of Week 10, at three time points: (1) pre-supplementation, (2) immediately before exercise and (3) immediately after exercise.
|
They will be measured using standard biochemical analyses.
|
During the first training session of Week 1 and the final training session of Week 10, at three time points: (1) pre-supplementation, (2) immediately before exercise and (3) immediately after exercise.
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Plasma norepinephrine responses to exercise
大体时间：During the first training session of Week 1 and the final training session of Week 10, at three time points: (1) pre-supplementation, (2) immediately before exercise and (3) immediately after exercise.
|
They will be measured using standard biochemical analyses.
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During the first training session of Week 1 and the final training session of Week 10, at three time points: (1) pre-supplementation, (2) immediately before exercise and (3) immediately after exercise.
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Guest NS, VanDusseldorp TA, Nelson MT, Grgic J, Schoenfeld BJ, Jenkins NDM, Arent SM, Antonio J, Stout JR, Trexler ET, Smith-Ryan AE, Goldstein ER, Kalman DS, Campbell BI. International society of sports nutrition position stand: caffeine and exercise performance. J Int Soc Sports Nutr. 2021 Jan 2;18(1):1. doi: 10.1186/s12970-020-00383-4.
- Lovallo WR, Whitsett TL, al'Absi M, Sung BH, Vincent AS, Wilson MF. Caffeine stimulation of cortisol secretion across the waking hours in relation to caffeine intake levels. Psychosom Med. 2005 Sep-Oct;67(5):734-9. doi: 10.1097/01.psy.0000181270.20036.06.
- Matsumura T, Takamura Y, Fukuzawa K, Nakagawa K, Nonoyama S, Tomoo K, Tsukamoto H, Shinohara Y, Iemitsu M, Nagano A, Isaka T, Hashimoto T. Ergogenic Effects of Very Low to Moderate Doses of Caffeine on Vertical Jump Performance. Int J Sport Nutr Exerc Metab. 2023 Jul 26;33(5):275-281. doi: 10.1123/ijsnem.2023-0061. Print 2023 Sep 1.
- Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Szewczyk NJ, Greenhaff PL, Smith K, Atherton PJ. Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling. FASEB J. 2015 Nov;29(11):4485-96. doi: 10.1096/fj.15-273755. Epub 2015 Jul 13.
- Pickering C, Kiely J. Are low doses of caffeine as ergogenic as higher doses? A critical review highlighting the need for comparison with current best practice in caffeine research. Nutrition. 2019 Nov-Dec;67-68:110535. doi: 10.1016/j.nut.2019.06.016. Epub 2019 Jun 26.
- Grgic J, Trexler ET, Lazinica B, Pedisic Z. Effects of caffeine intake on muscle strength and power: a systematic review and meta-analysis. J Int Soc Sports Nutr. 2018 Mar 5;15:11. doi: 10.1186/s12970-018-0216-0. eCollection 2018.
- Grgic J, Grgic I, Pickering C, Schoenfeld BJ, Bishop DJ, Pedisic Z. Wake up and smell the coffee: caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses. Br J Sports Med. 2020 Jun;54(11):681-688. doi: 10.1136/bjsports-2018-100278. Epub 2019 Mar 29.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2026年2月20日
初级完成 (实际的)
2026年5月30日
研究完成 (实际的)
2026年6月7日
研究注册日期
首次提交
2026年1月30日
首先提交符合 QC 标准的
2026年2月7日
首次发布 (实际的)
2026年2月13日
研究记录更新
最后更新发布 (实际的)
2026年7月14日
上次提交的符合 QC 标准的更新
2026年7月12日
最后验证
2026年7月1日
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- 2026/01-1792
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
是的
IPD 计划说明
从本信息中提取的所有个人数据（IPD）将与支持研究结果发表的支持性数据一同共享。
与数据设置相关的数据字典也会被存储。
IPD 共享时间框架
数据请求将在文章发表6个月后被接受；数据将可访问36个月。
IPD 共享访问标准
数据共享请求必须由研究人员提出，并需具备科学依据和伦理批准。
请求将被评估，被认为合适的请求将签署保密协议和数据使用协议。
请求将通过 abdullah.demirli@iuc.edu.tr
电子邮件地址接收。
IPD 共享支持信息类型
- 研究方案
- 树液
- 分析代码
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.