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Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence (ImRs_LLM_DeanG)

2026年5月3日 更新者：Stanisław Karkosz、University of Social Sciences and Humanities, Warsaw

The aim of the study is to examine the effect of imagery rescripting (ImRs) in the context of utilizing large language models (LLMs). Intervention will involve the prior presentation of the most aversive fragment of the memory, the so-called 'hotspot.' This intervention will allow for the replication of the effect described by Dibbets and Arntz (2016), according to which the prior activation of the most emotional element of a memory enhances the effectiveness of ImRs.

The study is also significant due to another ongoing study in which a substantial number of participants have already been examined; however, due to the exhaustion of funds, it was not possible to utilize the remainder of the recruited sample. Investigating an additional condition will allow for a more complete utilization of the available participant pool and significantly increase the project's scientific value by comparing the traditional ImRs mechanism with its AI-generated version.

研究概览

地位

招聘中

条件

干预/治疗

详细说明

This pilot randomized controlled trial will explore the application of large language models (LLMs) in the development of personalized therapeutic interventions. The study will focus on the emotional and psychophysiological effects of listening to autobiographical scenarios based on participants' childhood experiences of parental criticism. All participants will be asked to recall and describe two critical and two neutral childhood memories. Based on this input, personalized scripts will be generated using Gemini, a large language model. Each script will be reviewed and, if necessary, modified by trained experimenters to ensure therapeutic coherence and alignment with imagery rescripting (ImRs) principles. On Day 1, all participants will listen to critical personalized scenarios during the laboratory session. The experimental group will listen to modified versions of the critical memory scripts, in which a therapist figure will intervene to address the child's unmet needs-an application of imagery rescripting. To assess physiological arousal, skin conductance will be continuously recorded throughout the session. After each scenario, participants will rate their emotional intensity and specific feelings (e.g., fear, sadness) on Likert scales. The group will receive the ImRs intervention after the initial scenario phase. One week later, all participants will complete follow-up questionnaires assessing generalized anxiety (GAD-7) and the frequency of intrusive thoughts related to the memories. In addition, a panel of licensed cognitive-behavioral therapists will evaluate the generated scenarios for therapeutic quality. Their feedback will be used to assess the acceptability and coherence of AI-assisted therapeutic scripts. The study will test the feasibility of using LLM-generated content in clinical settings and aims to determine whether such interventions can reduce distress and intrusiveness while eliciting measurable emotional and physiological responses

Hypotheses:

The criticism scenarios generated by the model will elicit fearful responses in all participants.

The level of fearful reaction evoked by the AI-generated criticism scenarios will correlate with participants' baseline fear of failure.

Participants in the ImRs group will report fewer intrusive thoughts and lower generalized anxiety levels one week after the intervention.

Magnitude of Prediction Error (operationalized as a difference in SCL response between hotspot and intervention parts of the scenario) will correlate positively with a decrease in the number of intrusive thoughts.

The magnitude of imagery difficulty during the rescripting part will correlate negatively with the magnitude of Prediction Error.

Subjective efficacy of intervention will be predicted by working alliance.

研究类型

介入性

注册 (估计的)

40

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

学习地点

  • 波兰
    • Wielkopolska
      • Poznan、Wielkopolska、波兰、61-619
        • 招聘中
        • SWPS University (University of Social Sciences and Humanities); Poznań Laboratory of Affective Neuroscience
        • 接触：
      • Poznan、Wielkopolska、波兰、61-619
        • 招聘中
        • SWPS University of Social Sciences and Humanities; Poznań Laboratory of Affective Neuroscience
        • 接触：

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人

接受健康志愿者

不

描述

Inclusion Criteria:

  • Age 18-35
  • Score ≥ 8 on GAD-7 (Plummer et al., 2016)
  • Ability to recall at least two childhood memories involving parental criticism

Exclusion Criteria:

  • History of prolonged physical or sexual abuse
  • Current psychotherapy or psychopharmacology
  • PTSD diagnosis (DSM-5 screening)
  • Substance abuse (TAPS tool)

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：基础科学
  • 分配：不适用
  • 介入模型：单组作业
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
实验性的：ImRs AI
Participants listened to personalized audio scripts based on their own childhood memories of parental criticism and neutral events. All participants heard both critical and neutral scenarios. At the end of the session, one critical scenario was presented in a modified version that included an imagery rescripting (ImRs) intervention, in which a therapist figure entered the imagined scene and addressed the child's unmet needs. All scripts were generated by the Gemini large language model and reviewed by experimenters. Participants rated their emotional responses and underwent continuous skin conductance recording during the session. Follow-up assessments were conducted one week later. (?)
行为的：Imagery Rescripting Intervention
Participants listened to a series of personalized audio scenarios based on their childhood memories of parental criticism and neutral events. At the end of the session, one critical scenario was presented in a modified version that included a therapeutic imagery rescripting (ImRs) intervention. In this script, a therapist figure entered the scene and addressed the child's unmet needs, following the standard rescripting format. The scripts were generated using the Gemini large language model and reviewed by trained experimenters to ensure coherence and therapeutic validity. The intervention aimed to reduce distress and intrusive thoughts related to the memory.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
绩效失败评估库存
大体时间：干预前（第1天）
绩效失败评估库存用于评估对失败的恐惧。 这是一份25项问卷，衡量了关于失败后果​​的主观信念的强度。 PFAI有五个子量表：害怕感到羞耻和尴尬；害怕贬低一个人的自尊心；害怕没有不确定的未来；害怕重要的人失去兴趣；并害怕使他人不安。 PFAI评分范围为35至175，得分较高，表明对失败的恐惧程度更高。
干预前（第1天）
侵入性思想频率（反省清单 - 适应）
大体时间：干预前（第1天）和1周的随访
与事件相关的反驳清单的修改版本将用于评估与自传批评记忆有关的思想的频率和侵入性。 该量表包括侵入性和反射性反省项目，范围从20到80，得分较高，表明与事件相关的反省水平较高。 基线和随访之间的分数变化将作为干预措施认知影响的指数。
干预前（第1天）和1周的随访
皮肤电导水平（SCL）
大体时间：在实验/干预期间（第1天）
在自传场景中，将连续记录电性活动，以评估生理唤醒。 SCL信号将在基线，临界条件和中性条件以及图像重架（IMRS）干预（仅实验组）期间进行分析。 数据将用于检查AI生成的批评脚本是否引起了唤醒。
在实验/干预期间（第1天）
情绪响应评分（主观）
大体时间：在实验/干预期间（第1天）
参与者将使用李克特量表在每种呈现的场景之后使用李克特量表对情绪反应的强度（恐惧，悲伤，唤醒等）进行评分。 分数将在1到10之间，得分较高，表明情绪反应更加激烈。 这些评分将有助于确定情绪参与并比较批评和中立内容之间以及群体之间的情感反应。
在实验/干预期间（第1天）
Generalized Anxiety Disorder DSM Scale (GAD)
大体时间：Screening, Pre-intervention (Day 1) and 1-week follow-up
DSM Scale (Craske et al., 2013, own translation); brief dimensional self-rating questionnaire for generalized anxiety disorder (American Psychiatric Association, 2013, Polish translation: translation made by the authors using a standard back-translation method, 2020). Scale consists of 10 items relating to the thoughts, feelings, and behaviors the subjects have experienced in the last 7 days. The answers are marked on a 4-point Likert scale (0=never, 4=all the time), with scores ranging 0-4.
Screening, Pre-intervention (Day 1) and 1-week follow-up

次要结果测量

结果测量
措施说明
大体时间
治疗师的脚本质量评分
大体时间：干预之前
一组认知行为的治疗师将以10点的李克特量表为1到20的AI生成和手动创建脚本，以进行治疗质量，连贯性和情感相关性。 更高的分数将表明更高的质量/连贯性/情感相关性。 平均治疗师评级将用于测试有关LLM生成的治疗含量可接受性的假设。
干预之前
对基于图像干预的有效性和适当性的问卷调查
大体时间：干预后（第1天）
将对实验组的参与者进行定制开发问卷，以评估他们对成像重试干预措施的主观评估。 该措施包括评估情绪强度，图像难度，对记忆修改的抵抗力，对治疗过程的信任，经验的现实主义以及其他情感和认知反应的项目。 项目以5点李克特量表进行评级，并分组为代表常见的治疗障碍和促进因子的子量表。 每个子量表范围为4到20，得分较高，表明图像技术的问题更高。 将分析总数和子量表分数，以探索哪些因素与干预接受和感知的有效性有关。
干预后（第1天）
水龙头工具 - 物质使用筛查
大体时间：仅筛选
烟草，酒精，处方药和其他物质使用工具（TAP）将用于筛查有问题的物质使用。 TAPS的自我报告版本由两个部分组成：（1）过去的12个月使用烟草，酒精，非法药物和处方药，以供非医学使用。 分数将从1（从未）到5（每天/几乎每天）的范围更高，得分较高，表明使用物质的频率更高。 根据研究的资格标准，分数将用于排除可能使用药物使用障碍的参与者。
仅筛选
创伤后应力症状量表（DSM）
大体时间：仅筛选
自我报告量表评估DSM-5标准定义的PTSD症状。 该仪器包括10个项目，以0-4的李克特量表评估前7天的症状频率。 总分范围为0到40。
仅筛选
工作联盟库存 - 简短修订
大体时间：干预后（第1天）
工作联盟库存 - 简短修订（WAI-SR）是一项12项自我报告措施，评估了三个分量表的治疗联盟的感知质量：目标，任务和债券。 每个子量表范围为4到20，得分较高，表明工作联盟因素的水平较高。 一般分数从12到60，得分较高，表明工作的联盟水平较高。 在这项研究中，WAI-SR被调整以评估参与者与AI拨动干预的联系和联盟的感觉（例如，使用的重新编写脚本和语音）。 分数将用于探索主观的联盟意识是否可以预测感知的有效性，情感影响或对干预的反应。
干预后（第1天）

其他结果措施

结果测量
措施说明
大体时间
贝克抑郁量清单
大体时间：仅筛选
贝克抑郁量表，第二版（BDI-II）是一份21个项目的自我报告问卷，评估了抑郁症状的严重性，总得分在0到63不等。 较高的分数表明抑郁症状较高。 在这项研究中，在筛查时进行了BDI-II，以评估基线抑郁症状。 虽然不用作正式结果变量，但BDI-II得分可能包括在探索性分析中，以检查其对情绪反应或干预接受的潜在调节作用。
仅筛选

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

University of Social Sciences and Humanities, Warsaw

调查人员

  • 首席研究员：Stanisław Karkosz, MA、SWPS University

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

  • Yao, Y., Duan, J., Xu, K., Cai, Y., Sun, Z., & Zhang, Y. (2024). A survey on large language model (llm) security and privacy: The good, the bad, and the ugly. High-Confidence Computing, 100211
  • Conroy, D. E. (2001). Progress in the development of a multidimensional measure of fear of failure: The Performance Failure Appraisal Inventory (PFAI). Anxiety, Stress and Coping, 14(4), 431-452.
  • Arntz, A. (2012). Imagery rescripting as a therapeutic technique: Review of clinical trials, basic studies, and research agenda. Journal of Experimental Psychopathology, 3(2), 189-208.
  • Bradley MM, Sambuco N, Lang PJ. Imagery, emotion, and bioinformational theory: From body to brain. Biol Psychol. 2023 Oct;183:108669. doi: 10.1016/j.biopsycho.2023.108669. Epub 2023 Aug 28.
  • McNeely J, Wu LT, Subramaniam G, Sharma G, Cathers LA, Svikis D, Sleiter L, Russell L, Nordeck C, Sharma A, O'Grady KE, Bouk LB, Cushing C, King J, Wahle A, Schwartz RP. Performance of the Tobacco, Alcohol, Prescription Medication, and Other Substance Use (TAPS) Tool for Substance Use Screening in Primary Care Patients. Ann Intern Med. 2016 Nov 15;165(10):690-699. doi: 10.7326/M16-0317. Epub 2016 Sep 6.
  • Mossman SA, Luft MJ, Schroeder HK, Varney ST, Fleck DE, Barzman DH, Gilman R, DelBello MP, Strawn JR. The Generalized Anxiety Disorder 7-item scale in adolescents with generalized anxiety disorder: Signal detection and validation. Ann Clin Psychiatry. 2017 Nov;29(4):227-234A.
  • Busseri MA, Tyler JD. Interchangeability of the Working Alliance Inventory and Working Alliance Inventory, Short Form. Psychol Assess. 2003 Jun;15(2):193-7. doi: 10.1037/1040-3590.15.2.193.</citation> <pubmed_id>12847779
  • Cann A, Calhoun LG, Tedeschi RG, Triplett KN, Vishnevsky T, Lindstrom CM. Assessing posttraumatic cognitive processes: the Event Related Rumination Inventory. Anxiety Stress Coping. 2011 Mar;24(2):137-56. doi: 10.1080/10615806.2010.529901.</citation> <pubmed_id>21082446
  • Dibbets P, Arntz A. Imagery rescripting: Is incorporation of the most aversive scenes necessary? Memory. 2016;24(5):683-95. doi: 10.1080/09658211.2015.1043307. Epub 2015 Jun 15.
  • LeBeau R, Mischel E, Resnick H, Kilpatrick D, Friedman M, Craske M. Dimensional assessment of posttraumatic stress disorder in DSM-5. Psychiatry Res. 2014 Aug 15;218(1-2):143-7. doi: 10.1016/j.psychres.2014.03.032. Epub 2014 Apr 5.
  • Leyton F, Olhaberry M, Moran J, De la Cerda C, Leon MJ, Sieverson C, Alfaro A, Hernandez C, Alvardo R, Steele H. Video Intervention Therapy for primary caregivers in a child psychiatry unit: a randomized feasibility trial. Trials. 2021 Oct 30;22(1):754. doi: 10.1186/s13063-021-05668-w.
  • Plummer F, Manea L, Trepel D, McMillan D. Screening for anxiety disorders with the GAD-7 and GAD-2: a systematic review and diagnostic metaanalysis. Gen Hosp Psychiatry. 2016 Mar-Apr;39:24-31. doi: 10.1016/j.genhosppsych.2015.11.005. Epub 2015 Nov 18.

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年4月1日

初级完成 (估计的)

2026年6月1日

研究完成 (估计的)

2026年7月1日

研究注册日期

首次提交

2026年4月27日

首先提交符合 QC 标准的

2026年4月27日

首次发布 (实际的)

2026年5月4日

研究记录更新

最后更新发布 (实际的)

2026年5月7日

上次提交的符合 QC 标准的更新

2026年5月3日

最后验证

2026年5月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • ImRs_LLM_DeanGrant

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

是的

IPD 计划说明

De-identified individual participant data (IPD) that underlie the results reported in the primary publication (including questionnaire scores, psychophysiological measures, and outcome ratings) will be made available upon reasonable request, beginning 6 months after publication and for a period of 5 years. Access will be granted for non-commercial research purposes only, upon approval of a data access proposal and, where applicable, institutional ethics clearance.

IPD 共享时间框架

Data will be available after publication and for up to 5 years.

IPD 共享访问标准

Requests should be submitted to the principal investigator (skarkosz@swps.edu.pl) and include a brief project description and intended use of data. Approved requests will receive access via a secure data repository or encrypted transfer.

IPD 共享支持信息类型

  • 研究方案
  • 树液

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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