Knee Pain and Lumbar Proprioception in Knee Osteoarthritis Patients

February 20, 2026 updated by: Doaa Rafat, Cairo University

Association Between Knee Pain and Lumbar Proprioception in Patients With Knee Osteoarthritis

Knee osteoarthritis (KOA), is a chronic degenerative joint pathology with a global prevalence of 22.9% in individuals aged 40 and over. It is a leading cause of disability and poor quality of life worldwide due to musculoskeletal pain and functional limitations. Musculoskeletal pain is the primary patient-reported outcome in patients with osteoarthritis (OA) and a major cause of disability and functional limitations this study was carried to investigate the correlation between knee pain and lumbar proprioception

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Detailed Description

Purpose of the study:

  1. To investigate the relationship between knee pain and lumbar proprioception in patient with knee osteoarthritis.
  2. To investigate the gender effect on the relationship between knee pain and lumbar proprioception in patient with knee osteoarthritis.
  3. To investigate a difference between different grades of knee osteoarthritis on the relationship between lumbar proprioception and knee pain.

fifty-six individuals of both sexes were recruited, their BMI ranged from 24.02 to 29.98. Between the ages of 40 and 60 years Pain was assessd by visual analoge scale and proprioception assessed by The Biodex system

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Observational

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
56

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Cairo, Egypt
        • Physical therapy College - Cairo university

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Between the ages of 40 and 60 years, fifty-six individuals of both sexes were recruited, their BMI ranged from 24.02 to 29.98.

Description

Inclusion Criteria:

  1. Male and female participants diagnosed with knee osteoarthritis.
  2. The participants diagnosed with grade one, grade two and grade three knee osteoarthritis.
  3. Subjects aged form 40-60 years old.
  4. All the participants complain of knee pain.
  5. Participants able to understand the commands.

Exclusion Criteria:

  • 1- Experienced serious trauma leading to fractures and dislocations of the spine.

    2- They have been diagnosed to have spinal deformities such as scoliosis, lumbar disc herniation and lumbar spondylolisthesis.

    3- They have infection/malignant spinal conditions. 4- They have cauda equine syndrome. 5- Anyone with psychological disorders (e.g. dementia or drug abuse). 6- Uncooperative participant 7- Anyone with grade four knee osteoarthritis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort

Group / Cohort

A group or subgroup of participants in an observational study that is assessed for biomedical or health outcomes.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
study group
fifty-six individuals of both sexes between the ages of 40 and 60 years with knee osteoarthritis
Other: porprioception
The Biodex system 3 was used to measure joint position error.

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
proprioception
Time Frame: at the baseline (day 1)

Joint position error was measured using the Biodex system 3. Before every test, the system was calibrated and stabilized.

The patient was placed in a seated compressed posture on the Biodex system chair. Two curved pads on the front of the legs allowed for individual adjustment of the knee blocks, and the patient's feet were supported in a way that they did not touch the floor, both thighs were stabilized by two straps, the pelvic brace was then applied and positioned as far down as possible to press firmly but comfortably against the superior aspect of the proximal thighs. The starting position for each participant was with their spines flexed at a 60° angle. As a "target position" for the individuals to maintain during the testing, the predetermined spinal ROM was set at 60° to 90° lumbar flexion. All subjects. After recording the subjects' absolute error (AE) values relative to the 90-degree target position for all three trials, the mean deviation was calculated
at the baseline (day 1)

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Pain intensity
Time Frame: at the baseline (day 1)
Pain intensity level was measured by applying the VAS. Each participant was made aware that the VAS as being 100 mm horizontal line with one end defined as (no pain = 0 mm), while the other end (Worst pain = 100 mm). Participant was asked to mark a spot on the line between that relates to their level of pain that on a scale of 0-100 mm where 0 mm means absence of pain and 100 mm worst pain. This procedure was repeated three times and average was recorded.
at the baseline (day 1)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Cairo University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
May 1, 2025

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
November 1, 2025

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
December 20, 2025

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
January 28, 2026

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
February 20, 2026

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
February 27, 2026

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
February 27, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
February 20, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • Physical Therapy 25055

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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