Knee Pain and Lumbar Proprioception in Knee Osteoarthritis Patients

Association Between Knee Pain and Lumbar Proprioception in Patients With Knee Osteoarthritis

Knee osteoarthritis (KOA), is a chronic degenerative joint pathology with a global prevalence of 22.9% in individuals aged 40 and over. It is a leading cause of disability and poor quality of life worldwide due to musculoskeletal pain and functional limitations. Musculoskeletal pain is the primary patient-reported outcome in patients with osteoarthritis (OA) and a major cause of disability and functional limitations this study was carried to investigate the correlation between knee pain and lumbar proprioception

Study Overview

• Status: Completed
• Conditions: Osteoarthritis (OA) of the Knee
• Intervention / Treatment: Other: porprioception

Detailed Description

Purpose of the study:

1. To investigate the relationship between knee pain and lumbar proprioception in patient with knee osteoarthritis.
2. To investigate the gender effect on the relationship between knee pain and lumbar proprioception in patient with knee osteoarthritis.
3. To investigate a difference between different grades of knee osteoarthritis on the relationship between lumbar proprioception and knee pain.

fifty-six individuals of both sexes were recruited, their BMI ranged from 24.02 to 29.98. Between the ages of 40 and 60 years Pain was assessd by visual analoge scale and proprioception assessed by The Biodex system

• Study Type: Observational
• Enrollment (Actual): 56

Contacts and Locations

Study Locations

• Egypt
  • Cairo, Egypt
    • Physical therapy College - Cairo university

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Between the ages of 40 and 60 years, fifty-six individuals of both sexes were recruited, their BMI ranged from 24.02 to 29.98.

Description

Inclusion Criteria:

1. Male and female participants diagnosed with knee osteoarthritis.
2. The participants diagnosed with grade one, grade two and grade three knee osteoarthritis.
3. Subjects aged form 40-60 years old.
4. All the participants complain of knee pain.
5. Participants able to understand the commands.

Exclusion Criteria:

• 1- Experienced serious trauma leading to fractures and dislocations of the spine.

  2- They have been diagnosed to have spinal deformities such as scoliosis, lumbar disc herniation and lumbar spondylolisthesis.

  3- They have infection/malignant spinal conditions. 4- They have cauda equine syndrome. 5- Anyone with psychological disorders (e.g. dementia or drug abuse). 6- Uncooperative participant 7- Anyone with grade four knee osteoarthritis

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
study group; fifty-six individuals of both sexes between the ages of 40 and 60 years with knee osteoarthritis	Other: porprioception; The Biodex system 3 was used to measure joint position error.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
proprioception	Joint position error was measured using the Biodex system 3. Before every test, the system was calibrated and stabilized. The patient was placed in a seated compressed posture on the Biodex system chair. Two curved pads on the front of the legs allowed for individual adjustment of the knee blocks, and the patient's feet were supported in a way that they did not touch the floor, both thighs were stabilized by two straps, the pelvic brace was then applied and positioned as far down as possible to press firmly but comfortably against the superior aspect of the proximal thighs. The starting position for each participant was with their spines flexed at a 60° angle. As a "target position" for the individuals to maintain during the testing, the predetermined spinal ROM was set at 60° to 90° lumbar flexion. All subjects. After recording the subjects' absolute error (AE) values relative to the 90-degree target position for all three trials, the mean deviation was calculated	at the baseline (day 1)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pain intensity	Pain intensity level was measured by applying the VAS. Each participant was made aware that the VAS as being 100 mm horizontal line with one end defined as (no pain = 0 mm), while the other end (Worst pain = 100 mm). Participant was asked to mark a spot on the line between that relates to their level of pain that on a scale of 0-100 mm where 0 mm means absence of pain and 100 mm worst pain. This procedure was repeated three times and average was recorded.	at the baseline (day 1)

Collaborators and Investigators

• Sponsor: Cairo University

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2025
• Primary Completion (Actual): November 1, 2025
• Study Completion (Actual): December 20, 2025

Study Registration Dates

• First Submitted: January 28, 2026
• First Submitted That Met QC Criteria: February 20, 2026
• First Posted (Actual): February 27, 2026

Study Record Updates

• Last Update Posted (Actual): February 27, 2026
• Last Update Submitted That Met QC Criteria: February 20, 2026
• Last Verified: February 1, 2026

More Information

Terms related to this study

• Keywords: Osteoarthritis; knee pain; Lumbar proprioception; Repositioning error.
• Additional Relevant MeSH Terms: Musculoskeletal Diseases; Arthritis; Joint Diseases; Rheumatic Diseases; Osteoarthritis
• Other Study ID Numbers: Physical Therapy 25055

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No