- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00003173
High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors
High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of high-dose thiotepa plus peripheral stem cell transplantation in treating patients with refractory solid tumors.
Study Overview
Status
Conditions
Detailed Description
OBJECTIVES:
- Evaluate the efficacy and toxicity of sequential cycles of high dose thiotepa with stem cell rescue and filgrastim in patients with malignancies refractory to conventional chemotherapy or for whom conventional therapy is not available.
- Evaluate the effectiveness of autologous stem cells in restoring hematopoiesis following high dose thiotepa.
OUTLINE: Patients are stratified by type of tumor (neuroectodermal CNS tumor vs non-neuroectodermal CNS tumor vs non-CNS small round blue cell tumor vs other non-CNS tumor).
Autologous stem cells are obtained prior to the administration of thiotepa. Patients who do not have peripheral blood stem cells available may undergo a bone marrow harvest instead. Thiotepa is administered as a 3 hour infusion daily for 3 consecutive days. Stem cells are reinfused approximately 72 hours following the completion of thiotepa. Filgrastim is administered the day following reinfusion of stem cells and continues until there is sufficient hematopoietic recovery.
The second course of thiotepa is administered 4 weeks following the first course in patients who have responding or stable disease, adequate stem cells, and no unacceptable toxicity. Patients receive a maximum of 2 courses.
PROJECTED ACCRUAL: Approximately 36 patients will be accrued for this study over 2 years.
Study Type
Enrollment (Anticipated)
Phase
- Phase 2
Contacts and Locations
Study Locations
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New York
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New York, New York, United States, 10021
- Memorial Sloan-Kettering Cancer Center
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New York, New York, United States, 10016
- NYU School of Medicine's Kaplan Comprehensive Cancer Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
DISEASE CHARACTERISTICS:
- Malignant solid tumors
- Must have failed conventional treatment or for whom conventional therapy is not available
Measurable disease by MRI or CT scan
- Intraocular retinoblastomas may be measured by direct visualization
- Germ cell tumors may be measured by tumor markers
- No known bone marrow involvement
PATIENT CHARACTERISTICS:
Age:
- Any age
Performance status:
- Lansky 60-100% for patients 16 and under
- Karnofsky 60-100% for patients over 16
Life expectancy:
- At least 8 weeks
Hematopoietic:
- Absolute neutrophil count at least 1,000/mm^3
- Platelet count at least 75,000/mm^3
- If parameters not met, must have adequate stem cell yield
Hepatic:
- Bilirubin no greater than 1.5 times the upper limit of normal (ULN)
- SGOT and SGPT no greater than 2.5 times the ULN (unless liver involvement by tumor)
Renal:
- Creatinine within normal limits OR
- Creatinine clearance at least 70 mL/min
Cardiovascular:
- Fractional shortening greater than 28% on echocardiogram OR
- Ejection fraction at least 55% on RNCA prior to first cycle of thiotepa
Pulmonary:
- DLCO greater than 55% of predicted (only required if there is clinical evidence of pulmonary dysfunction)
Other:
- Not pregnant or nursing
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Prior bone marrow or peripheral blood stem cell rescue allowed
Chemotherapy:
- At least 4 weeks since prior chemotherapy if absolute neutrophil count is less than 1,000/mm^3 or platelet count is less than 75,000/mm^3, and recovered (i.e. adequate stem cells collected to predict hematopoietic recovery)
- No concurrent chemotherapy except for dexamethasone for antiedema effects
Endocrine therapy:
- No concurrent use of corticosteroids used solely as antiemetics
Radiotherapy:
- At least 4 weeks since radiotherapy if absolute neutrophil count is less than 1,000/mm^3 or platelet count is less than 75,000/mm^3, and recovered (i.e. adequate stem cells collected to predict hematopoietic recovery)
- No concurrent radiotherapy
Surgery:
- Not specified
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
Collaborators and Investigators
Collaborators
Investigators
- Study Chair: Ira Dunkel, MD, Memorial Sloan Kettering Cancer Center
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
- unspecified childhood solid tumor, protocol specific
- stage III malignant testicular germ cell tumor
- unspecified adult solid tumor, protocol specific
- adult central nervous system germ cell tumor
- recurrent ovarian germ cell tumor
- stage III ovarian germ cell tumor
- stage IV ovarian germ cell tumor
- recurrent malignant testicular germ cell tumor
- extragonadal germ cell tumor
- childhood central nervous system germ cell tumor
- childhood germ cell tumor
- childhood teratoma
- childhood malignant testicular germ cell tumor
- childhood malignant ovarian germ cell tumor
- childhood extragonadal germ cell tumor
- recurrent childhood malignant germ cell tumor
- intraocular retinoblastoma
- recurrent retinoblastoma
Additional Relevant MeSH Terms
- Nervous System Diseases
- Neoplasms by Histologic Type
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Eye Diseases
- Retinal Diseases
- Neoplasms, Neuroepithelial
- Neuroectodermal Tumors
- Neoplasms, Nerve Tissue
- Eye Diseases, Hereditary
- Eye Neoplasms
- Retinal Neoplasms
- Neoplasms
- Neoplasms, Germ Cell and Embryonal
- Nervous System Neoplasms
- Central Nervous System Neoplasms
- Retinoblastoma
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Antineoplastic Agents
- Immunosuppressive Agents
- Immunologic Factors
- Antineoplastic Agents, Alkylating
- Alkylating Agents
- Myeloablative Agonists
- Thiotepa
Other Study ID Numbers
- 97-089
- P30CA008748 (U.S. NIH Grant/Contract)
- MSKCC-97089A3
- NYU-97-7
- NCI-G97-1366
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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