Healthy Aging and Memory Study

September 14, 2007 updated by: National Institute on Aging (NIA)

Alzheimer's Disease Prevention Instrument Protocol

This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in Alzheimer's Disease (AD) primary prevention trials.

Study Overview

Status

Completed

Conditions

Detailed Description

This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in AD primary prevention trials. The new or improved measures that have been developed will then be evaluated in 650 nondemented subjects enrolled in a simulated Alzheimer's disease prevention trial. Once enrolled, subjects will be followed for four years with annual clinical evaluations and interim six-month phone calls.

Study Type

Observational

Enrollment

650

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Alabama
      • Birmingham, Alabama, United States, 35294-1150
        • University of Alabama, Birmingham
    • Arizona
      • Sun City, Arizona, United States, 85351
        • Sun Health Research Institute
    • California
      • Irvine, California, United States, 92697-4285
        • University of California, Irvine
      • La Jolla, California, United States, 92037
        • University of California, San Diego
      • Los Angeles, California, United States, 90033-1039
        • University of Southern California
      • Los Angeles, California, United States, 90095-1769
        • University of California, Los Angeles
      • Palo Alto, California, United States, 94304
        • Stanford/Va Aging Clinical Research Center
      • Sacramento, California, United States, 95817
        • University of California, Davis
    • Connecticut
      • New Haven, Connecticut, United States, 06510
        • Yale University School of Medicine
    • District of Columbia
      • Washington, District of Columbia, United States, 20007
        • Georgetown University Medical Center
    • Florida
      • Boca Raton, Florida, United States, 33486
        • Baumel-Eisner Neuromedical Institute, Boca Raton
      • Ft Lauderdale, Florida, United States, 33321
        • Baumel-Eisner Ft Lauderdale
      • Jacksonville, Florida, United States, 32224
        • Mayo Clinic, Jacksonville
      • Miami Beach, Florida, United States, 33140
        • Wien Center for Memory Disorders
      • Miami Beach, Florida, United States, 33154
        • Baumel-Eisner Neuromedical Institute, Miami Beach
      • Tampa, Florida, United States, 33617
        • University of South Florida, Tampa
    • Georgia
      • Atlanta, Georgia, United States, 30329
        • Emory University
    • Illinois
      • Chicago, Illinois, United States, 60611
        • Northwestern University
      • Chicago, Illinois, United States, 60612
        • Rush Alzheimer's Disease Center
    • Indiana
      • Indianapolis, Indiana, United States, 46202
        • Indiana University Alzheimer's Center
    • Kentucky
      • Lexington, Kentucky, United States, 40506
        • University of Kentucky, Lexington
    • Maryland
      • Baltimore, Maryland, United States, 21287-7218
        • Johns Hopkins University
    • Massachusetts
      • Boston, Massachusetts, United States, 02115
        • Brigham and Women's Hospital
      • Boston, Massachusetts, United States, 02118
        • Boston University School Of Medicine
    • Michigan
      • Ann Arbor, Michigan, United States, 48109-2007
        • Michigan Alzheimer's Disease Research Center
    • Minnesota
      • Rochester, Minnesota, United States, 55901
        • Mayo Alzheimer's Disease Center
    • Missouri
      • St. Louis, Missouri, United States, 63108
        • Washington University
    • Nevada
      • Las Vegas, Nevada, United States, 89102
        • University of Nevada, Las Vegas
    • New York
      • New York, New York, United States, 10032
        • Columbia University
      • New York, New York, United States, 10016
        • New York University School of Medicine
      • New York, New York, United States, 10029
        • Mt. Sinai Medical Center
      • Rochester, New York, United States, 14620
        • University of Rochester
    • Ohio
      • Cleveland, Ohio, United States, 44120-1013
        • University Hospitals of Cleveland
    • Oregon
      • Portland, Oregon, United States, 97201
        • Oregon Health Sciences University
    • Pennsylvania
      • Philadelphia, Pennsylvania, United States, 19104
        • University of Pennsylvania
      • Pittsburgh, Pennsylvania, United States, 15213
        • University of Pittsburgh
    • Rhode Island
      • Pawtucket, Rhode Island, United States, 02860
        • Memorial Hospital of Rhode Island (Brown University)
    • South Carolina
      • North Charleston, South Carolina, United States, 29406
        • Medical University of South Carolina
    • Texas
      • Dallas, Texas, United States, 75390-9070
        • University of Texas Southwestern Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

75 years and older (Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • 75 years or older.
  • Fluent in English or Spanish.
  • Stable medical condition for four weeks prior to screening visit.
  • Stable medications for four weeks prior to screening visit.
  • Either cognitively normal, or mild cognitive impairment. If MCI, the subject's CDR at screening have a global score of 0.5.
  • mMMSE score greater than 88 for subjects with at least 8 years education, or greater than 80 for subjects with less than 8 years education, and FCSRT total free plus cued recall score greater than 44 with 3 learning trials.
  • Willing to participate in four to five year follow-up study.
  • Willing to identify person who can serve as informant.
  • At least six years education or work history sufficient to exclude mental retardation

Exclusion Criteria:

  • Meets DSM IV criteria for dementia
  • History of clinically significant medical illness that would interfere with participation in trial, including active malignancy, myocardial infarction, or cerebrovascular accident within the past year
  • Alcohol or substance abuse and/or active major psychiatric disorders
  • Concurrent participation in a clinical drug trial
  • History of mental retardation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Institute on Aging (NIA)

Investigators

  • Study Director: Steven H. Ferris, PhD, NYU Langone Health

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted

April 30, 2002

First Submitted That Met QC Criteria

April 30, 2002

First Posted (Estimate)

May 1, 2002

Study Record Updates

Last Update Posted (Estimate)

September 18, 2007

Last Update Submitted That Met QC Criteria

September 14, 2007

Last Verified

September 1, 2007

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IA0032

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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