Tanespimycin in Treating Young Patients With Recurrent or Refractory Leukemia or Solid Tumors

A Multicenter Phase I Trial of 17-N-allylamino-17-demethoxy Geldanamycin (17-AAG, NSC #330507) in Patients With Recurrent/Refractory Pediatric Solid Tumors (Ewing's Sarcoma, Desmoplastic Small Round Cell Tumor, Osteosarcoma, Neuroblastoma, and Rhabdomyosarcoma) and Leukemia

This phase I trial is studying the side effects and best dose of tanespimycin in treating young patients with recurrent or refractory leukemia or selected solid tumors. Drugs used in chemotherapy, such as tanespimycin, work in different ways to stop cancer cells from dividing so they stop growing or die.

Study Overview

• Status: Completed
• Conditions: Childhood Chronic Myelogenous Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Neuroblastoma; Recurrent Osteosarcoma; Recurrent Childhood Rhabdomyosarcoma; Metastatic Osteosarcoma; Disseminated Neuroblastoma; Previously Treated Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Childhood Soft Tissue Sarcoma; Childhood Desmoplastic Small Round Cell Tumor
• Intervention / Treatment: Other: laboratory biomarker analysis; Other: pharmacological study; Drug: tanespimycin

Detailed Description

PRIMARY OBJECTIVES:

I. Determine the dose-limiting toxicity and maximum tolerated dose (MTD) of 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) in pediatric patients with recurrent or refractory leukemia or selected solid tumors.

II. Determine the levels of key proteins known to influence cancer cell survival and proliferation in patients treated with this drug at the MTD.

SECONDARY OBJECTIVES:

I. Determine the pharmacokinetics of this drug in these patients. II. Evaluate effects of genetic polymorphisms known to alter the activity of enzymes involved in the metabolism of this drug.

III. Correlate the alteration of fludeoxyglucose F18 accumulation with tumor response in patients treated with this drug.

OUTLINE: This is a dose-escalation, multicenter study. Patients are stratified according to diagnosis (leukemia vs solid tumor).

Patients receive tanespimycin IV over 2-6 hours on days 1, 4, 8, and 11 (for patients with solid tumors) OR days 1, 4, 8, 11, 15, and 18 (for patients with leukemia). Courses for all patients repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of tanespimycin until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. At least 15 patients are treated at the MTD.

Patients are followed for 30 days.

• Study Type: Interventional
• Enrollment (Actual): 70
• Phase: Phase 1

Contacts and Locations

Study Locations

• United States
  • New York
    • New York, New York, United States, 10065
      • Memorial Sloan-Kettering Cancer Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 21 years (ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Histologically confirmed diagnosis of 1 of the following malignancies:

  • Leukemia

    • Lymphoid, myeloid, or mixed lineage

    • Relapsed (in second or greater relapse) or refractory disease, confirmed by 1 of the following:

      • Bone marrow relapse, defined as either M3 bone marrow (> 25% blasts in the bone marrow aspirate) OR M2 bone marrow (5-25% blasts in the bone marrow aspirate) at any time after complete remission is attained
      • CNS relapse, defined as at least 5 WBC/mL by cytospin of any cerebrospinal fluid (CSF) specimen OR less than 5 WBC/mL by cytospin of 2 consecutive CSF specimens obtained >= 4 weeks apart and having definitive confirmation that blasts are derived from the original leukemic clone by molecular cytogenetics, multiparameter flow cytometry, or immunostaining of >= 2 antigens
    • Patients with underlying chronic myeloid leukemia must have > 25% blasts in the bone marrow aspirate
    • Patients with M3 bone marrow AND extramedullary sites of disease, other than leptomeningeal disease, are eligible

  • Solid tumor

    • One of the following tumor types:

      • Neuroblastoma
      • Ewing's sarcoma
      • Osteosarcoma
      • Desmoplastic small round cell tumor
      • Rhabdomyosarcoma
    • Progressed after prior standard therapy OR no effective standard therapy exists
    • Measurable or nonmeasurable disease
• No known brain metastases

• No active leptomeningeal leukemia, defined by the following criteria:

  • WBC > 5/mm^3 in cerebrospinal fluid (CSF)
  • Unequivocal confirmation of leukemic blasts in CSF by cell morphology
• No symptomatic CNS disease (e.g., cranial nerve abnormalities) without cytologic abnormality in CSF
• Performance status - Karnofsky 70-100% (for patients > 10 years of age)
• Performance status - Lansky 70-100% (for patients =< 10 years of age)
• More than 8 weeks
• Absolute neutrophil count >= 750/mm^3
• Platelet count >= 75,000/mm^3 (transfusion independent)
• Hemoglobin >= 8.5 g/dL (transfusion allowed)
• Bilirubin < 1.5 mg/dL
• ALT and AST =< 2.5 times upper limit of normal (ULN)
• INR =< 1.5 times ULN
• Albumin > 2.0 g/dL
• Creatinine =< 1.5 times ULN for age
• Creatinine clearance or radioisotope glomerular filtration rate > 60 mL/min
• Ejection fraction >= 50%
• Shortening fraction >= 28%

• QTc < 450 msec for men (470 msec for women)

  • No congenital long QT syndrome
• LVEF > 40% by MUGA
• No symptomatic congestive heart failure
• No cardiac arrhythmia
• No New York Heart Association class III or IV heart failure
• No myocardial infarction within the past year
• No uncontrolled dysrhythmias
• No poorly controlled angina
• More than 12 months since active ischemic heart disease
• No history of serious ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation >= 3 beats in a row)
• No left bundle branch block
• No other significant cardiac disease
• No pulmonary fibrosis by radiography
• No ongoing or active bacterial or fungal infection
• No other uncontrolled illness
• No psychiatric illness or social situation that would preclude study compliance
• No history of serious allergic reaction attributed to eggs or dimethyl sulfoxide
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Recovered from all immunotherapy
• At least 6 months since prior allogeneic stem cell transplantation
• At least 3 months since prior autologous stem cell transplantation
• At least 2 weeks since prior biologic agents (e.g., monoclonal antibodies)
• At least 1 week since prior filgrastim (G-CSF) or sargramostim (GM-CSF)
• Recovered from all prior chemotherapy
• At least 2 weeks since prior chemotherapy (for patients with leukemia only)
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) (for patients with solid tumors)
• No prior oxaliplatin
• No concurrent corticosteroids except for the treatment of adrenal crises in patients with suppressed hypothalamic-pituitary-adrenal axis response OR for treatment of allergic reactions to medications or blood products
• Recovered from all prior radiotherapy
• At least 6 months since prior radiotherapy to >= 50% of the pelvis
• At least 6 months since prior radiotherapy to substantial bone marrow, including total body irradiation
• At least 4 weeks since prior local (small port) radiotherapy
• No prior radiotherapy to the heart
• At least 1 week since prior retinoids
• No concurrent antiretroviral therapy for HIV-positive patients
• No concurrent medication to control arrhythmias
• No concurrent medications that prolong or may prolong QTc interval
• No other concurrent investigational agents
• No other concurrent anticancer therapy

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: NA
• Interventional Model: SINGLE_GROUP
• Masking: NONE

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

EXPERIMENTAL: Treatment (tanespimycin); Patients receive tanespimycin IV over 2-6 hours on days 1, 4, 8, and 11 (for patients with solid tumors) OR days 1, 4, 8, 11, 15, and 18 (for patients with leukemia). Courses for all patients repeat every 21 days in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of tanespimycin until the MTD is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. At least 15 patients are treated at the MTD.

Other: laboratory biomarker analysis; Correlative studies; Other: pharmacological study; Correlative studies; Other Names: pharmacological studies; Drug: tanespimycin; Given IV; Other Names: 17-AAG

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
MTD, defined as the highest dose level with an observed incidence of DLT in no more than 1 out of 6 patients treated at a particular dose level	21 days

Secondary Outcome Measures

Outcome Measure	Time Frame
Change in Hsp90 client protein levels in relation to dose of tanespimycin	Baseline to 21 days

Collaborators and Investigators

• Sponsor: National Cancer Institute (NCI)
• Investigators: Principal Investigator: Tanya Trippett, Memorial Sloan Kettering Cancer Center

Study record dates

Study Major Dates

• Study Start: September 1, 2004
• Primary Completion (ACTUAL): August 1, 2007

Study Registration Dates

• First Submitted: October 6, 2004
• First Submitted That Met QC Criteria: October 7, 2004
• First Posted (ESTIMATE): October 8, 2004

Study Record Updates

• Last Update Posted (ESTIMATE): June 4, 2013
• Last Update Submitted That Met QC Criteria: June 3, 2013
• Last Verified: June 1, 2013

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Immune System Diseases; Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Neoplasms, Glandular and Epithelial; Disease Attributes; Bone Marrow Diseases; Hematologic Diseases; Myeloproliferative Disorders; Neoplasms, Neuroepithelial; Neoplasms, Germ Cell and Embryonal; Neoplasms, Nerve Tissue; Leukemia, Lymphoid; Neoplasms, Bone Tissue; Neoplasms, Connective Tissue; Neoplasms, Muscle Tissue; Myosarcoma; Neoplasms; Sarcoma; Leukemia; Leukemia, Myeloid; Recurrence; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma, Ewing; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Osteosarcoma; Neuroblastoma; Rhabdomyosarcoma; Neuroectodermal Tumors; Neuroectodermal Tumors, Primitive; Neuroectodermal Tumors, Primitive, Peripheral; Rhabdomyosarcoma, Embryonal; Desmoplastic Small Round Cell Tumor
• Other Study ID Numbers: NCI-2012-01456; U01CA069856 (U.S. NIH Grant/Contract); 04-069; POETIC-MSKCC-04069; CDR0000391010; NCI-6323; MSKCC-04069