Efficacy Study of Thymosin alpha1 & Pegylated Interferon-alpha2a to Treat Chronic Hepatitis B

July 20, 2011 updated by: Seoul National University Hospital

A Multicenter, Randomized, Controlled Trial of Combination Therapy for HBeAg Positive Chronic Hepatitis B: Comparing Thymosin Alpha 1 and Pegylated Interferon-alpha2a With Pegylated Interferon-alpha2a Alone.

The purpose of this study is to determine the optimal treatment duration of antiviral therapy for chronic hepatitis B.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Thymosin alpha1/interferon combination therapy has been known as an effective antiviral therapy for chronic hepatitis B. It is superior to interferon single therapy since the sustained viral response rate of combination therapy used to be about 70% compared with that of single interferon therapy(20%). Until now, the combination therapy including 6-month treatment of thymosin alpha1 has been as effective as 12-month treatment of thymosin alpha1. We hypothesized that thymosin alpha1 is an immune potentiator so, the shorter duration of thymosin alpha1 treatment might be as effective as the prolonged treatment duration.

In detail, we designed to perform this clinical study comparing the combination of pegylated interferon and thymosin alpha1 with pegylated interferon alone. Total treatment duration of both parallel groups will be 12 months, and the combination therapy will be lasted for the first 3 months followed by the next, ongoing pegylated interferon single therapy for 9 months.

Study Type

Interventional

Enrollment (Actual)

52

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Korea, Republic of
    • Chongno-gu
      • Seoul, Chongno-gu, Korea, Republic of, 110-744
        • Seoul National University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • HBsAg positive and anti-HBs negative for more than 6 months
  • HBeAg positive
  • HBV DNA titer more than 100,000 IU/mL
  • serum ALT more than upper normal limit value, but no more than 10 times upper normal limit value

Exclusion Criteria:

  • the history of antiviral therapy for chronic hepatitis B within the recent 6 months
  • HAV IgM Ab + and/or HCV Ab + and/or HDV Ab and/or HIV Ab +
  • the sign of decompensated liver disease
  • the history of hemoglobinopathy, autoimmune hepatitis, alcoholic liver disease
  • pregnant or lactating woman
  • neutrophil count less than 1,500/mm3 or platelet count less than 90,000/mm3
  • serum creatinine more than 1.5 times upper normal limit value
  • the sign of alcoholic or drug addiction within the recent 1 year
  • the history of psychotic disorder especially like depression
  • immunologically mediated disease
  • the history of esophageal varix
  • the history of severe heart disease or respiratory disease
  • the history of severe epilepsy or current use of antiepileptic drug
  • the sign of malignancy or suggestive of malignancy or the history of malignancy, the recurrence rate within 2 years of which is more than 20%
  • the history of systemic anticancer treatment including radiation therapy or immunotherapy including systemic corticosteroid
  • the history of major organ transplantation
  • the history of medically uncontrolled thyroid disease
  • the history or sign of severe retinopathy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: 1
Pegylated Interferon-alpha2a
Drug: Pegylated Interferon-alpha2a
180 microgram s.c. injection weekly
Active Comparator: 2
Thymosin alpha1 & Pegylated Interferon-alpha2a
Drug: Thymosin alpha1 & Pegylated Interferon-alpha2a
Pegylated interferon 180 microgram s.c. injection weekly Thymosin 1.6 mg s.c. injection twice per week

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
HBeAg seroconversion, HBV DNA titer<20,000 IU/mL
Time Frame: 48 week and 96 week
48 week and 96 week

Secondary Outcome Measures

Outcome Measure
Time Frame
Normalization of serum ALT, loss of HBeAg and HBsAg, production of anti-HBs
Time Frame: 48 week and 96 week
48 week and 96 week

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Seoul National University Hospital

Collaborators

Roche Pharma AG
SciClone Pharmaceuticals

Investigators

  • Principal Investigator: Jung H Yoon, M.D., Seoul National University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2005

Primary Completion (Actual)

August 1, 2008

Study Completion (Actual)

August 1, 2008

Study Registration Dates

First Submitted

February 13, 2006

First Submitted That Met QC Criteria

February 13, 2006

First Posted (Estimate)

February 14, 2006

Study Record Updates

Last Update Posted (Estimate)

July 21, 2011

Last Update Submitted That Met QC Criteria

July 20, 2011

Last Verified

July 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 12-05-008

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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