- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00434265
Obesity, Physical Inactivity or Dietary Fat ?
August 29, 2011 updated by: University Hospital, Strasbourg, France
OBESITY, PHYSICAL INACTIVITY OR DIETARY FAT ? Role of Physical Activity in the Trafficking of Dietary Fatty Acids Varying in Length and Saturation Degree.
Obesity is the consequence of a chronic disequilibrium of fat balance.
Genetic factors determine predisposition to obesity, but the most often mentioned idea is that environmental factors, such as a high-fat diet and a sedentary lifestyle, join to favour weight gain and explain the increased prevalence of obesity in our westernized societies.
Since lipogenesis is negligible in humans, obesity represents the consequence of altered fat partitioning between oxidation and storage, likely due to a preferential directing of dietary fat towards adipose tissue and away from muscle.
Interventions that favour partitioning of dietary fat towards muscle for oxidation might thus protect against weight gain.
Exercise may be one kind of such intervention but the scant data on dietary fat metabolism does not allow clear conclusions, in particular in obese subjects.
One question concerns the impact of the type of fat eaten: the effects of physical inactivity may vary according to the length and saturation degree of the fatty acids.
We hypothesize that 1) physical activity of moderate intensity, independently of its effect on energy balance, will favor a preferential trafficking towards adipose tissue, will modify the expression of genes implicated in fat oxidation and storage and partly correct the abnormalities observed in obese subjects, 2) effects of physical activity vary according to the saturation degree of fat.
Twelve obese subjects, aged 18 to 55, will undergo tests before and after 2 months of training at current recommendations to ascertain dietary fat partitioning using stable isotopes and to determine changes in gene expression with muscle and adipose tissue microbiopsies.
Study Overview
Study Type
Interventional
Enrollment (Actual)
12
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Strasbourg, France, 67091
- Service des Explorations Fonctionelles Respiratoires et de l'Exercice - Hôpital Civil
-
Strasbourg, France, 67098
- Service de Médecine Interne et de Nutrition - Hôpital de Hautepierre
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 55 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- Men between 18 and 55
- IMC >25 and <30 kg/m2 and waist circumference >102 cm
- Familial antecedents of obesity
- Physical inactivity (PAL<1.5, according to MOSPA-questionnaire and accelerometry)
- Acceptation of physical training and body weight control during the study
Exclusion Criteria:
- Any drug interfering with energetic or lipid metabolism
- Any contradiction to moderate physical training
- Diabetes or arterial hypertension treatment
- Any other pathology (cardiovascular, psychiatric, renal or hepatic disease, viral hepatitis or VIH)
- Consumption of more than 40 g alcohol per day
- Recent voluntary or involuntary weight modification (3kg the next three months)
- A recent trip outside France before and during stable isotope measures.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Proportion of fat oxidation induced by physical training, according to fat type (oleate vs palmitate)
|
Secondary Outcome Measures
Outcome Measure |
---|
Variations of oleate and palmitate postprandial kinetic in different lipoprotein fractions
|
Expression of different muscle and adipose tissue genes
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Study Director: Chantal Simon, MD, Hôpitaux Universitaires de Strasbourg
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
March 1, 2007
Study Completion (Actual)
August 1, 2011
Study Registration Dates
First Submitted
February 12, 2007
First Submitted That Met QC Criteria
February 12, 2007
First Posted (Estimate)
February 13, 2007
Study Record Updates
Last Update Posted (Estimate)
August 30, 2011
Last Update Submitted That Met QC Criteria
August 29, 2011
Last Verified
January 1, 2009
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 3493
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Obesity
-
Central Hospital, Nancy, FranceNot yet recruiting
-
University of MinnesotaNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Active, not recruitingAdolescent ObesityUnited States
-
Helsinki University Central HospitalKarolinska Institutet; Folkhälsan Researech CenterEnrolling by invitation
-
Istanbul Medipol University HospitalMedipol UniversityCompletedObesity, Morbid | Obesity, Adolescent | Obesity, Abdominal | Weight, Body | Obesity, VisceralTurkey
-
Queen Fabiola Children's University HospitalNot yet recruitingMorbid Obesity | Adolescent Obesity | Bariatric SurgeryBelgium
-
Azienda Ospedaliero-Universitaria Consorziale Policlinico...Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies; Istituti... and other collaboratorsCompletedMorbid Obesity | Metabolically Healthy ObesityItaly
-
Washington University School of MedicinePatient-Centered Outcomes Research Institute; Pennington Biomedical Research... and other collaboratorsActive, not recruitingOvernutrition | Nutrition Disorders | Overweight | Body Weight | Pediatric Obesity | Body Weight Changes | Childhood Obesity | Weight Gain | Adolescent Obesity | Obesity, Childhood | Overweight and Obesity | Overweight or Obesity | Overweight AdolescentsUnited States
-
Fundació Sant Joan de DéuRecruitingObesity, Childhood | Obesity, AdolescentSpain
-
Consorcio Centro de Investigación Biomédica en...Maimónides Biomedical Research Institute of Córdoba; Instituto de Salud Carlos... and other collaboratorsActive, not recruiting
-
University of HoustonBaylor College of MedicineCompleted
Clinical Trials on Physical training
-
University Health Network, TorontoCanadian Institutes of Health Research (CIHR); Boehringer IngelheimRecruitingPulmonary Disease, Chronic ObstructiveCanada
-
The Hong Kong Polytechnic UniversityUniversity of Santo TomasUnknownMild Cognitive ImpairmentPhilippines
-
Chiang Mai UniversityCompletedMild Cognitive ImpairmentThailand
-
Universiti Tunku Abdul RahmanCompleted
-
University of Sao Paulo General HospitalFundação de Amparo à Pesquisa do Estado de São PauloCompletedPlatelet Aggregation | Exercise Training | Acute Myocardial InfarctionBrazil
-
University Hospital, Clermont-FerrandNot yet recruitingHealthy Normal Weight Women | Constitutionally Lean WomenFrance
-
Paracelsus Medical UniversityCompletedChronic Obstructive Pulmonary DiseaseAustria
-
István KósaRecruiting
-
Khon Kaen UniversityCompleted
-
Cairo UniversityCompleted