Quantifying Lung Tumor Movement Under Deep Inspiration Breath Holds

Quantifying Lung Tumor Movement Under Dep Inspiration Breath Holds

Radiotherapy is a common treatment for lung cancer. One Challenge of delivering radiation treatment to lung tumors accurately is tumor movement which occurs as a patient breathes. In some situations, tumors move enough during breathing so that some or all of the tumor may be missed by a radiation treatment. One way to decrease the amount a lung tumor moves during radiotherapy treatments is for patients to held their breath briefly during a radiation treatment. By doing this, a patient's lung tumor may not move as much as it would during regular breathing. In this study, the investigators aim to study patients with lung cancers which move during breathing. Patients will be asked to hold their breath after inspiration while a CT scan of their lung tumor is obtained. The purpose of this study is to study how much less patients' lung tumors move when they hold their breath

Study Overview

• Status: Completed
• Conditions: Lung Cancer
• Intervention / Treatment: Other: CT scan of the chest under deep inspiration breath hold

• Study Type: Observational
• Enrollment (Actual): 8

Contacts and Locations

Study Locations

• Canada
  • Alberta
    • Edmonton, Alberta, Canada, T6G 1Z2
      • Cross Cancer Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

patients with any primary lung cancer who are undergoing radiotherapy or chemoradiotherapy

Description

Inclusion Criteria:

• biopsy confirmed primary lung cancer
• undergoing radiotherapy or chemoradiotherapy
• able to perform adequate deep inspiration breath hold
• patients of childbearing potential must practice adequate contraception
• signed study-specific informed consent form

Exclusion Criteria:

• unable to perform adequate deep inspiration breath hold
• prior tumor resection
• prior chest or neck RT
• pregnant

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
1; single arm study	Other: CT scan of the chest under deep inspiration breath hold; computed tomography scan of the chest under dep inspiration breath hold conditions

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
tumor movement	12 months

Collaborators and Investigators

• Sponsor: AHS Cancer Control Alberta
• Collaborators: Cross Cancer Institute

Study record dates

Study Major Dates

• Study Start: April 1, 2008
• Primary Completion (Actual): January 1, 2011

Study Registration Dates

• First Submitted: March 24, 2008
• First Submitted That Met QC Criteria: March 25, 2008
• First Posted (Estimate): March 26, 2008

Study Record Updates

• Last Update Posted (Estimate): February 17, 2016
• Last Update Submitted That Met QC Criteria: February 12, 2016
• Last Verified: August 1, 2011

More Information

Terms related to this study

• Keywords: lung cancer; tumor motion
• Additional Relevant MeSH Terms: Pathologic Processes; Respiratory Tract Diseases; Neoplasms; Respiration Disorders; Lung Diseases; Neoplasms by Site; Respiratory Tract Neoplasms; Thoracic Neoplasms; Lung Neoplasms; Respiratory Aspiration
• Other Study ID Numbers: LU-23980