European Quality Improvement Programme for Acute Coronary Syndromes (EQUIP-ACS)

July 15, 2008 updated by: Royal Brompton & Harefield NHS Foundation Trust

Improving the Management of Non-ST Elevation Acute Coronary Syndrome: Systematic Evaluation of a Quality Improvement Programme

The main hypothesis to be tested is that the use of a quality improvement programme will lead to measurable improvements in the management of care and use of evidence based treatments for patients presenting to hospital with non-ST elevation acute coronary syndromes.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

3500

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Annecy, France
        • Recruiting
        • Centre hospitalier de la région d'Annecy
        • Principal Investigator:
          • Loic Belle
      • Chambery, France
        • Recruiting
        • Centre Hospitalier de Chambery
        • Principal Investigator:
          • Christian Chaussard
      • Clermont Ferrand, France
        • Recruiting
        • Cardiology dept. B, CHU Hopital G. Montpied
        • Principal Investigator:
          • Bernard Citron
      • Grenoble, France
        • Recruiting
        • CHU de Grenoble
        • Principal Investigator:
          • Gerald Vanzetto
      • Riom, France
        • Recruiting
        • Centre Hospitalier de Riom Guy Thomas
        • Principal Investigator:
          • Laurence Flork
      • Romans-sur-Isere, France
        • Recruiting
        • Hopitaux Drome Nord de Romans-sur-Isere
        • Principal Investigator:
          • Christian Chaussard
      • Ussel, France
        • Recruiting
        • Centre Hospitalier d'Ussel
        • Principal Investigator:
          • Alain Berenfeld
      • Voiron, France
        • Recruiting
        • Centre Hospitalier Pierre Bazin
        • Principal Investigator:
          • Hubert Mann
  • Italy
      • Cesena, Italy
        • Recruiting
        • Ospedale M. Bufalini
        • Principal Investigator:
          • Flavio Tartagni
      • Forli, Italy
        • Recruiting
        • Ospedale Morgagni-Pierantoni
        • Principal Investigator:
          • Filippo Ottani
      • Livorno, Italy
        • Recruiting
        • Ospedale di Livorno
        • Principal Investigator:
          • Michele Galli
      • Macerata, Italy
        • Recruiting
        • Ospedale Generale Provinciale di Macerata
        • Principal Investigator:
          • Gian Luigi Morgagni
      • Mirano, Italy
        • Recruiting
        • Ospedale Civile Di Mirano
        • Principal Investigator:
          • Luca Favero
  • Poland
      • Ciechanow, Poland
        • Recruiting
        • Szpital w Ciechanowie
        • Principal Investigator:
          • Bogdan Zbyszynski
      • Grodzisk Mazowiecki, Poland
        • Recruiting
        • Szpital Zachodni
        • Principal Investigator:
          • Marek Stopinski
      • Grojec, Poland
        • Recruiting
        • Szpital w Grojcu
        • Principal Investigator:
          • Zbigniew Binio
      • Kielce, Poland
        • Recruiting
        • Swietofrzyskie Centrum Chorob Serca
        • Principal Investigator:
          • Marianna Janion
      • Plock, Poland
        • Recruiting
        • Szpital w Plocku
        • Principal Investigator:
          • Maciej Rynkiewicz
      • Radom, Poland
        • Recruiting
        • Radomski Szpital Specjalistyczny
        • Principal Investigator:
          • Piotr Achremczyk
      • Radom, Poland
        • Recruiting
        • Szpital Specjalistyczny SPZOZ w Radom
        • Principal Investigator:
          • Bozena Wrzosek
      • Siedlce, Poland
        • Recruiting
        • Szpital w Siedlcach
        • Principal Investigator:
          • Piotr Kolodziej
      • Warsaw, Poland
        • Recruiting
        • SP CSK- Medical University of Warsaw
        • Principal Investigator:
          • Grzegorz Opolski
      • Wloclawek, Poland
        • Recruiting
        • Szpital we Wloclawku
        • Principal Investigator:
          • Jerzy Kopaczewski
  • Spain
      • Badalona, Spain
        • Recruiting
        • Hospital Universitario Germans Trias
        • Principal Investigator:
          • Antonio Curos Abadal
      • Barcelona, Spain
        • Recruiting
        • Hospital Del Mar
        • Principal Investigator:
          • Lluis Recasens Gracia
      • Barcelona, Spain
        • Recruiting
        • Hospital Universitario Vall d'Hebron
        • Principal Investigator:
          • Jose Barrabes
      • Girona, Spain
        • Recruiting
        • Hospital Josep Trueta
        • Principal Investigator:
          • Joan Sala
      • Tarragona, Spain
        • Recruiting
        • Hospital Universitario Joan XXIII
        • Principal Investigator:
          • Ramon de Castro
      • Terrassa-Barcelona, Spain
        • Recruiting
        • Hospital de Terrassa
        • Principal Investigator:
          • Antonio Sanchez Hidalgo
      • Tortosa, Spain
        • Recruiting
        • Hospital de Tortosa Virgen de la Cinta
        • Principal Investigator:
          • David Bierge Valero
  • United Kingdom
      • Antrim, United Kingdom
        • Recruiting
        • Antrim Area Hospital
        • Principal Investigator:
          • Thomas Trouton
      • Barnet, United Kingdom
        • Recruiting
        • Barnet General Hospital
        • Principal Investigator:
          • Ameet Bakhai
      • Essex, United Kingdom
        • Recruiting
        • Basildon Hospital
        • Principal Investigator:
          • Rajesh Aggarwal
      • Warwick, United Kingdom
        • Recruiting
        • Warwick Hospital
        • Principal Investigator:
          • Najmi Qureshi
      • Wigan, United Kingdom
        • Recruiting
        • Royal Albert Edward Infirmary
        • Principal Investigator:
          • Sanjay Arya
      • Yeovil, United Kingdom
        • Recruiting
        • Yeovil District Hospital
        • Principal Investigator:
          • George Chung
      • York, United Kingdom
        • Recruiting
        • York District Hospital
        • Principal Investigator:
          • Maurice Pye

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

No older than 80 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

Patients with a good clinical history of ACS and at least one of the following:

  • New or transient ST or T wave changes on the ECG consistent with acute myocardial ischaemia
  • Elevation of troponin or other cardiac markers to levels indicative of myocardial necrosis according to local laboratory values

Exclusion Criteria:

  • Evidence of persistent ST elevation on the ECG
  • Use of early reperfusion therapy
  • Patients >80 years
  • Patients transferred from another hospital

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Health Services Research
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: QI
Quality Improvement Centres
Behavioral: Quality Improvement Programme
Quality Improvement training programme
No Intervention: Non-QI
No Quality Improvement Programme

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Composite of 7 outcome measures to assess aggregate potential for improvement in care using the QI programme:1:risk stratification within 24 hrs, 2:early coronary angiography, 3:anticoagulation, 4:beta-blockers, 5:statins, 6:ACE-inhibitors, 7:Clopidogrel
Time Frame: 10 months
10 months

Secondary Outcome Measures

Outcome Measure
Time Frame
Clinical outcomes at discharge including death and myocardial infarction
Time Frame: 10 months
10 months
Estimated costs of care for patients
Time Frame: 10 months
10 months
Estimated costs and economic evaluation of potential cost-effectiveness of QI programme
Time Frame: 10 months
10 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Royal Brompton & Harefield NHS Foundation Trust

Collaborators

GlaxoSmithKline
Uppsala University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2007

Primary Completion (Anticipated)

December 1, 2008

Study Completion (Anticipated)

February 1, 2009

Study Registration Dates

First Submitted

July 11, 2008

First Submitted That Met QC Criteria

July 15, 2008

First Posted (Estimate)

July 16, 2008

Study Record Updates

Last Update Posted (Estimate)

July 16, 2008

Last Update Submitted That Met QC Criteria

July 15, 2008

Last Verified

July 1, 2008

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • EQUIP-ACS 1

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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