Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease

Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease: Dual-source Computed Tomography Compared With Invasive Coronary Angiography and Transthoracic Echocardiography

We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.

Study Overview

• Status: Unknown
• Conditions: Coronary Disease; Aortic Valve Stenosis
• Intervention / Treatment: Other: DSCT, TTE

Detailed Description

Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis.

The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.

• Study Type: Interventional
• Enrollment (Anticipated): 65
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Switzerland
  • Luzern
    • Lucerne, Luzern, Switzerland, 6000
      • Recruiting
      • Luzerner Kantonsspital, Department of Cardiology
      • Contact: Paul Erne, MD; Phone Number: ++41 41 205 51 06; Email: paul.erne@ksl.ch
      • Contact: Christoph Auf der Maur, MD; Phone Number: ++41 41 2005 51 48
      • Principal Investigator: Paul Erne, MD
      • Sub-Investigator: Christoph Auf der Maur, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 40 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patients with aortic valve disease who were scheduled to undergo cardiac surgery

Exclusion Criteria:

• Hemodynamic instability
• Renal insufficiency (serum creatinine level > 133umol/L)
• Known allergy to iodinated contrast agents
• Non-treated hyperthyreosis

Study Plan

How is the study designed?

Design Details

• Primary Purpose: DIAGNOSTIC
• Allocation: NA
• Interventional Model: SINGLE_GROUP
• Masking: NONE

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: AVS, CAD; DSCT	Other: DSCT, TTE; One assessment each

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Quality of cardiac imaging in computed tomography	After comparison of imaging measurements

Collaborators and Investigators

• Sponsor: Luzerner Kantonsspital

Study record dates

Study Major Dates

• Study Start: May 1, 2007
• Primary Completion (ANTICIPATED): December 1, 2013

Study Registration Dates

• First Submitted: October 3, 2008
• First Submitted That Met QC Criteria: October 3, 2008
• First Posted (ESTIMATE): October 6, 2008

Study Record Updates

• Last Update Posted (ESTIMATE): April 17, 2013
• Last Update Submitted That Met QC Criteria: April 16, 2013
• Last Verified: April 1, 2013

More Information

Terms related to this study

• Keywords: DSCT, coronary artery disease, aortic valve stenosis
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Pathological Conditions, Anatomical; Aortic Valve Disease; Heart Valve Diseases; Ventricular Outflow Obstruction; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease; Aortic Valve Stenosis; Constriction, Pathologic
• Other Study ID Numbers: Cardiac imaging DSCT