Effects of Ritalin on Postural Stability of Old Adults

Effects of Methylphenidate on Postural Stability of Old Adults Under Single and Dual Task Conditions.

Experimental design overview The proposed project is a prospective experimental study design. independent old adults(age 65 years old and older) who do not suffer from balance problems willing to participate in the study will be tested with well-established measuring techniques of Balance control before and 2 hours after taking of Methylphenidate (Ritalin) in the movement and Rehabilitation Laboratory at BGU. An automated algorithm will be used to extract standardized stabilogram-diffusion parameters from each of the COP data sets collected during quiet standing. These parameters include diffusion coefficients, critical displacement, critical time and scaling exponents for both lateral and anterior-posterior sway directions (Collins & De Luca, 1993). For each of the conditions (before and 1 hour after the use of Ritalin) in three task conditions single task; dual task (concentrating and identifying specific music); and just Listening to a relaxing music. Participants will be required to stand on the platform 10 times for 30 s. For each trial, they will be instructed to sway as little as possible.

Study Overview

• Status: Completed
• Conditions: Postural Imbalance
• Intervention / Treatment: Drug: Methylphenidate

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Israel
  • Beer-Sheva, Israel, 84105
    • SorokaUMC

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Age 65 years old and older
• independent elderly adults
• do not suffer from balance prblems
• minimental score 24 and above

Exclusion Criteria:

• old adults who suffer from neurological disease or stroke
• old adults who suffer from psychiatric state
• old adults who suffer from orthopedic condition (1/2 a year after a fracture in the lower limb)
• old adults who suffer from heart conditions
• old adults who suffer from blindness

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: QUADRUPLE

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Methylphenidate	Drug: Methylphenidate; The effect of ritalin on postural stability of old adults (65 years old and over) will be measured using RCT study design

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Postural sway measures	Time 1: pre test' and hour later time 2: post testinng proceedure

Collaborators and Investigators

• Sponsor: Soroka University Medical Center
• Investigators: Study Chair: Zmir Shorer, m, Soroka University Medical Centar; Study Director: Yan Press, MD, Soroka University Medical Center

Study record dates

Study Major Dates

• Study Start: July 1, 2011
• Primary Completion (ACTUAL): January 1, 2012
• Study Completion (ACTUAL): June 1, 2012

Study Registration Dates

• First Submitted: January 6, 2009
• First Submitted That Met QC Criteria: January 6, 2009
• First Posted (ESTIMATE): January 7, 2009

Study Record Updates

• Last Update Posted (ESTIMATE): June 20, 2012
• Last Update Submitted That Met QC Criteria: June 19, 2012
• Last Verified: December 1, 2008

More Information

Terms related to this study

• Keywords: Postural Control; Dual tasking; Methylphenidate (Ritalin); old adults
• Additional Relevant MeSH Terms: Physiological Effects of Drugs; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Neurotransmitter Uptake Inhibitors; Membrane Transport Modulators; Dopamine Agents; Dopamine Uptake Inhibitors; Central Nervous System Stimulants; Methylphenidate
• Other Study ID Numbers: SOR476508CTIL; MZ4765