Effects of Liposuction and Exercise Training on Metabolism, Lipid Profile and Adiposity in Women

Liposuction is the most popular aesthetic surgery in Brasil and worldwide. Evidence showing that adipose tissue is a metabolically active tissue led to the suggestion that liposuction could be a viable method for the improvement of metabolic profile through the immediate loss of adipose tissue. Studies about the effects of liposuction on metabolic profile are conflicting. A few studies report the improvement of insulin sensitivity, inflammatory markers and lipid profile, others observe no changes and a few report the worsening of metabolic profile. In addition, animal studies show a compensatory growth of intact adipose tissue in response to lipectomy. Physical exercise improves insulin sensitivity, lipid profile, inflammatory balance, adipose tissue distribution and increases or preserves free fat mass. Therefore, liposuction and physical exercise seem to act on similar tissues of the body. To the investigators knowledge, there are no studies about the associated effects of liposuction and exercise in humans. However, one can suggest that exercise training associated with liposuction could: [1] attenuate or block the possible fat recovery or compensatory growth; [2] block or reverse the possible harmful effects of liposuction; or [3] exert an additive or synergistic effect to the possible beneficial effects induced by liposuction on metabolic and hormonal profile and inflammatory balance.

Study Overview

• Status: Completed
• Conditions: Healthy Subjects
• Intervention / Treatment: Procedure: exercise

• Study Type: Interventional
• Enrollment (Actual): 40
• Phase: Early Phase 1

Contacts and Locations

Study Locations

• Brazil
  • SP
    • São Paulo, SP, Brazil, 05508-900
      • Escola de Educação Física e Esporte da Universidade de São Paulo

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 36 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• 20 to 35-year old healthy subjects with a BMI of 22 to 28 Kg/m2;
• Non-smokers;
• Present stable body weight for 6 months (without variations exceeding 4 kg);
• Be in use contraceptive pill for at least 6 months;

Exclusion Criteria:

• Health problems that impede surgery or exercise training;
• Be in chronic use of antibiotics or antiinflammatory medication.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: exercise; exercise plus liposuction	Procedure: exercise; combined resistance and aerobic training
No Intervention: sedentary; physical inactivity plus liposuction

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Body composition	Body composition will be assessed by hydrostatic weighing in order to measure fat and lean mass and by computer tomography, in order to measure abdominal total, subcutaneous and visceral fat areas and femoral and pelvic subcutaneous fat areas.	2 months post-intervention
Body composition	Body composition will be assessed by hydrostatic weighing in order to measure fat and lean mass and by computer tomography, in order to measure abdominal total, subcutaneous and visceral fat areas and femoral and pelvic subcutaneous fat areas.	6 months post-intervention

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Insulin Sensitivity	Insulin sensitivity will be assessed by an oral glucose tolerance test	2 months post-intervention
Total cholesterol, LDL-c, HDL-c, VLDL-c and triacylglycerol plasma levels		2 months post-intervention
Cytokine plasma levels - IL-6, TNF-alpha, IL-10, leptin and adiponectin levels		2 months post-intervention
Insulin Sensitivity	Insulin sensitivity will be assessed by an oral glucose tolerance test	6 months post-intervention
Total cholesterol, LDL-c, HDL-c, VLDL-c and triacylglycerol plasma levels		6 months post-intervention
Cytokine plasma levels - IL-6, TNF-alpha, IL-10, leptin and adiponectin levels		6 months post-intervention

Collaborators and Investigators

• Sponsor: University of Sao Paulo
• Investigators: Principal Investigator: Antonio H Lancha Jr, PhD, University of Sao Paulo

Publications and helpful links

General Publications

• Benatti F, Solis M, Artioli G, Montag E, Painelli V, Saito F, Baptista L, Costa LA, Neves R, Seelaender M, Ferriolli E, Pfrimer K, Lima F, Roschel H, Gualano B, Lancha A Jr. Liposuction induces a compensatory increase of visceral fat which is effectively counteracted by physical activity: a randomized trial. J Clin Endocrinol Metab. 2012 Jul;97(7):2388-95. doi: 10.1210/jc.2012-1012. Epub 2012 Apr 26.

Study record dates

Study Major Dates

• Study Start: August 1, 2010
• Primary Completion (Actual): April 1, 2011
• Study Completion (Actual): April 1, 2011

Study Registration Dates

• First Submitted: June 25, 2010
• First Submitted That Met QC Criteria: August 2, 2010
• First Posted (Estimate): August 3, 2010

Study Record Updates

• Last Update Posted (Estimate): May 13, 2011
• Last Update Submitted That Met QC Criteria: May 11, 2011
• Last Verified: April 1, 2011

More Information

Terms related to this study

• Keywords: exercise; adiposity; metabolism; Liposuction
• Additional Relevant MeSH Terms: Overnutrition; Nutrition Disorders; Overweight; Body Weight; Obesity
• Other Study ID Numbers: EEFEUSP-LIPO